دورية أكاديمية
أعرض في EDS

Antimelanoma effect of manool in 2D cell cultures and reconstructed human skin models.

التفاصيل البيبلوغرافية
العنوان: Antimelanoma effect of manool in 2D cell cultures and reconstructed human skin models.
المؤلفون: Nicolella HD; University of Franca, Franca, São Paulo, Brazil., Ribeiro AB; University of Franca, Franca, São Paulo, Brazil., Munari CC; Eleve Science, Ribeirão Preto, São Paulo, Brazil., Melo MR; University of Franca, Franca, São Paulo, Brazil., Ozelin SD; University of Franca, Franca, São Paulo, Brazil., da Silva LHD; University of Franca, Franca, São Paulo, Brazil., Marquele-Oliveira F; Eleve Science, Ribeirão Preto, São Paulo, Brazil., Orenha RP; University of Franca, Franca, São Paulo, Brazil., Veneziani RCS; University of Franca, Franca, São Paulo, Brazil., Parreira RLT; University of Franca, Franca, São Paulo, Brazil., Tavares DC; University of Franca, Franca, São Paulo, Brazil.
المصدر: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2023 Mar; Vol. 37 (3), pp. e23282. Date of Electronic Publication: 2022 Dec 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Wiley, c1998-
مواضيع طبية MeSH: Melanoma*/metabolism , Skin Neoplasms* , Diterpenes*/pharmacology, Humans ; Animals ; Mice ; Cell Line, Tumor ; Apoptosis ; Cell Culture Techniques ; Cell Proliferation
مستخلص: Melanoma is the most aggressive and lethal type of skin cancer, characterized by therapeutic resistance. In this context, the present study aimed to investigate the cytotoxic potential of manool, a diterpene from Salvia officinalis L., in human (A375) and murine (B16F10) melanoma cell lines. The analysis of cytotoxicity using the XTT assay showed the lowest IC 50 after 48 h of treatment with the manool, being 17.6 and 18.2 µg/ml for A375 and B16F10, respectively. A selective antiproliferative effect of manool was observed on the A375 cells based on the colony formation assay, showing an IC 50 equivalent to 5.6 µg/ml. The manool treatments led to 43.5% inhibition of the A375 cell migration at a concentration of 5.0 µg/ml. However, it did not affect cell migration in the B16F10 cells. Cell cycle analysis revealed that the manool interfered in the cell cycle of the A375 cells, blocking the G2/M phase. No changes in the cell cycle were observed in the B16F10 cells. Interestingly, manool did not induce apoptosis in the A375 cells, but apoptosis was observed after treatment of the B16F10 cells. Additionally, manool showed an antimelanoma effect in a reconstructed human skin model. Furthermore, in silico studies, showed that manool is stabilized in the active sites of the tubulin dimer with comparable energy concerning taxol, indicating that both structures can inhibit the proliferation of cancer cells. Altogether, it is concluded that manool, through the modulation of the cell cycle, presents a selective antiproliferative activity and a potential antimelanoma effect.
(© 2022 Wiley Periodicals LLC.)
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معلومات مُعتمدة: 2016/24269-7 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة: Keywords: A375; B16F10; Salvia officinalis; anti-melanoma; in silico; tubulin
المشرفين على المادة: AT5PJ0PV00 (manool)
0 (Diterpenes)
تواريخ الأحداث: Date Created: 20221221 Date Completed: 20230314 Latest Revision: 20230314
رمز التحديث: 20231215
DOI: 10.1002/jbt.23282
PMID: 36541366
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-0461
DOI:10.1002/jbt.23282