دورية أكاديمية
Clostridium Symbiosum Sepsis Diagnosed Using Next-Generation Sequencing in a 2 Year Old Child: A Case Report.
| العنوان: | Clostridium Symbiosum Sepsis Diagnosed Using Next-Generation Sequencing in a 2 Year Old Child: A Case Report. |
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| المؤلفون: | Pan Y; Department of Pediatrics, the First Affiliated Hospital of Yangtze University, Jingzhou, China., Fan Q; Department of Pediatrics, the First Affiliated Hospital of Yangtze University, Jingzhou, China. |
| المصدر: | Fetal and pediatric pathology [Fetal Pediatr Pathol] 2023 Jun; Vol. 42 (3), pp. 518-521. Date of Electronic Publication: 2022 Dec 21. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101230972 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1551-3823 (Electronic) Linking ISSN: 15513815 NLM ISO Abbreviation: Fetal Pediatr Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Philadelphia, PA : Taylor & Francis, c2004- |
| مواضيع طبية MeSH: | Clostridium symbiosum* , Sepsis*/diagnosis , Sepsis*/genetics , Sepsis*/drug therapy, Male ; Infant, Newborn ; Infant ; Humans ; Child, Preschool ; Anti-Bacterial Agents/therapeutic use ; Meropenem/therapeutic use ; Sulbactam/therapeutic use ; High-Throughput Nucleotide Sequencing |
| مستخلص: | Background : Sepsis is a severe illness that can affect preterm, term, and young infants, and is often associated with negative cultures. Case report : A 2-year-old boy, with a previous partial colectomy after birth, presented with abdominal complaints and clinical sepsis. We empirically treated with meropenem and linezolid. Blood cultures were sterile, and fecal cultures demonstrated no pathogenes. Metagenomic next-generation sequencing identified Clostridium symbiosum from blood sample. The result supported the continued use of the antibiotic regimen. After 1 week, CRP and PCT returned to normal and subsequent de-escalation therapy (cefotaxime sodium sulbactam and metronidazole) was used for anaerobic bacteria. Conclusions : mNGS identified an anaerobic agent responsible for sepsis. From the published sensitivities, the organism was sensitive to the original empiric antibiotic therapy. |
| فهرسة مساهمة: | Keywords: Clostridium symbiosum; Sepsis; anaerobes; partial colectomy |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) FV9J3JU8B1 (Meropenem) S4TF6I2330 (Sulbactam) |
| تواريخ الأحداث: | Date Created: 20221221 Date Completed: 20230529 Latest Revision: 20230529 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/15513815.2022.2158696 |
| PMID: | 36541613 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1551-3823 |
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| DOI: | 10.1080/15513815.2022.2158696 |