دورية أكاديمية
Medication with fenbendazole in feed: plasma concentrations and effects on hepatic xenobiotic metabolizing enzymes in swine.
العنوان: | Medication with fenbendazole in feed: plasma concentrations and effects on hepatic xenobiotic metabolizing enzymes in swine. |
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المؤلفون: | Ichinose P; Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil, Buenos Aires, Argentina. paulaichinose@vet.unicen.edu.ar.; Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Tandil, Buenos Aires, Argentina. paulaichinose@vet.unicen.edu.ar., Miró MV; Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil, Buenos Aires, Argentina.; Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Tandil, Buenos Aires, Argentina., Larsen K; Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil, Buenos Aires, Argentina.; Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Tandil, Buenos Aires, Argentina., Lanusse C; Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil, Buenos Aires, Argentina.; Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Tandil, Buenos Aires, Argentina., Lifschitz A; Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil, Buenos Aires, Argentina.; Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Tandil, Buenos Aires, Argentina., Virkel G; Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil, Buenos Aires, Argentina. gvirkel@vet.unicen.edu.ar.; Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Tandil, Buenos Aires, Argentina. gvirkel@vet.unicen.edu.ar. |
المصدر: | Veterinary research communications [Vet Res Commun] 2023 Jun; Vol. 47 (2), pp. 803-815. Date of Electronic Publication: 2022 Dec 21. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Switzerland NLM ID: 8100520 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7446 (Electronic) Linking ISSN: 01657380 NLM ISO Abbreviation: Vet Res Commun Subsets: MEDLINE |
أسماء مطبوعة: | Publication: [Cham] : Springer Original Publication: [Amsterdam] : Elsevier, 1980- |
مواضيع طبية MeSH: | Fenbendazole*/pharmacology , Fenbendazole*/metabolism , Anthelmintics*/pharmacology , Anthelmintics*/metabolism, Animals ; Female ; Swine ; Xenobiotics/metabolism ; Liver/metabolism |
مستخلص: | Fenbendazole (FBZ), a benzymidazole (BZD) anthelmintic drug, is used for in-feed medication in pigs. BZD-containing drugs may induce cytochrome P450 isozymes (CYPs), particularly those members of the CYP1A subfamily. The current research evaluated the plasma and liver availability and metabolism of FBZ and its metabolites, oxfendazole (OFZ) and fenbendazole sulphone (FBZSO (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.) |
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معلومات مُعتمدة: | PIP 2021-2023 - 11220200101380CO Consejo Nacional de Investigaciones Científicas y Técnicas; PICT 2018-0830 Fondo para la Investigación Científica y Tecnológica |
فهرسة مساهمة: | Keywords: Feeding; Fenbendazole; Hepatic cytochrome P450; Metabolites; Pigs; Plasma concentrations |
المشرفين على المادة: | 621BVT9M36 (Fenbendazole) 0 (Xenobiotics) 0 (Anthelmintics) |
تواريخ الأحداث: | Date Created: 20221221 Date Completed: 20230526 Latest Revision: 20230526 |
رمز التحديث: | 20231215 |
DOI: | 10.1007/s11259-022-10041-6 |
PMID: | 36542192 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-7446 |
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DOI: | 10.1007/s11259-022-10041-6 |