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Characterization and in vivo toxicological evaluation of multi-walled carbon nanotubes: a low-dose repeated intratracheal administration study.

التفاصيل البيبلوغرافية
العنوان: Characterization and in vivo toxicological evaluation of multi-walled carbon nanotubes: a low-dose repeated intratracheal administration study.
المؤلفون: Bubols GB; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil.; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Arbo MD; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil.; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Peruzzi CP; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil.; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Cestonaro LV; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil.; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Altknecht LF; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil., Fão N; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil.; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Göethel G; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil.; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Nascimento SN; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil.; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Paese K; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratório 405 de Nanotecnologia, Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil., Amaral MG; Centro de Desenvolvimento Tecnológico (CDTec), Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil., Bergmann CP; Laboratório de Materiais Cerâmicos (LACER), Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil., Pohlmann AR; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil.; Instituto de Química, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil., Guterres SS; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratório 405 de Nanotecnologia, Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil., Garcia SC; Laboratório de Toxicologia (LATOX), Faculdade de Farmácia, Anexo II, Universidade Federal Do Rio Grande Do Sul (UFRGS), Rua São Luis, 150, Anexo II, Santana, Porto Alegre, CEP: 90620-170, Brazil. solange.garcia@ufrgs.br.; Programa de Pós-Graduação Em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil. solange.garcia@ufrgs.br.
المصدر: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Mar; Vol. 30 (13), pp. 36405-36421. Date of Electronic Publication: 2022 Dec 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
أسماء مطبوعة: Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
مواضيع طبية MeSH: Nanotubes, Carbon*/toxicity , Pulmonary Fibrosis*/pathology, Animals ; Lung ; Time Factors ; Bronchoalveolar Lavage Fluid
مستخلص: This study characterized and investigated the toxicity of two multi-walled carbon nanotubes (MWCNT) NM-401 and NM-403 at 60 and 180 µg after four repeated intratracheal instillations; follow-up times were 3, 7, 30, and 90 days after the last instillation. NM-401 was needle-like, long, and thick, while NM-403 was entangled, short, and thin. Both MWCNT types induced transient pulmonary and systemic alterations in renal function and oxidative lipid damage markers in recent times. Animals showed general toxicity in the immediate times after exposures, in addition to increased pulmonary LDH release at day 3. In further times, decreased liver and kidney relative weights were noted at higher MWCNT doses. Lung histological damages included pulmonary fibrosis, for both MWCNT types, similarly to asbestos; single liver and kidney histological alterations were present. Repeated instillations led to persistent pulmonary damage at low doses, and possibly the extrapulmonary effects may be associated with the consecutive exposures.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة: 14/50928-2 Fundação de Amparo à Pesquisa do Estado de São Paulo; 465687/2014-8 Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة: Keywords: Lung toxicity; MWCNT; NM-401; NM-403; Nanotoxicology; Rat
المشرفين على المادة: 0 (Nanotubes, Carbon)
تواريخ الأحداث: Date Created: 20221222 Date Completed: 20230329 Latest Revision: 20230329
رمز التحديث: 20240628
DOI: 10.1007/s11356-022-24653-7
PMID: 36547826
قاعدة البيانات: MEDLINE
الوصف
تدمد:1614-7499
DOI:10.1007/s11356-022-24653-7