دورية أكاديمية
أعرض في EDS

Procalcitonin Evaluation of Antibiotic Use in COVID-19 Hospitalised Patients (PEACH): Protocol for a Retrospective Observational Study.

التفاصيل البيبلوغرافية
العنوان: Procalcitonin Evaluation of Antibiotic Use in COVID-19 Hospitalised Patients (PEACH): Protocol for a Retrospective Observational Study.
المؤلفون: Euden J; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4EP, UK., Pallmann P; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4EP, UK., Grozeva D; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4EP, UK., Albur M; Severn Infectious Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol BS10 5NB, UK., Bond SE; Medicines Optimisation and Pharmacy Services, Pindersfield Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield WF1 4DG, UK., Brookes-Howell L; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4EP, UK., Dark P; Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK., Hellyer T; Critical Care Department, Royal Victoria Infirmary, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Hopkins S; UK Health Security Agency, London SW1P 3JR, UK., Howard P; School of Healthcare, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.; Department of Pharmacy and Medicines Optimisation, NHS England, Leeds LS2 7UE, UK., Llewelyn MJ; Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9PS, UK., Maboshe W; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4EP, UK., McCullagh IJ; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Perioperative and Critical Care Department, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK., Ogden M; Public and Patient Involvement Representative, NIHR, London SW1A 2NS, UK., Parsons H; Department of Microbiology, Laboratory Medicine, Northern General Hospital, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield S5 7AU, UK., Partridge D; Department of Microbiology, Laboratory Medicine, Northern General Hospital, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield S5 7AU, UK., Powell N; Pharmacy Department, Royal Cornwall Hospital, Royal Cornwall Hospitals NHS Foundation Trust, Truro TR1 3LJ, UK., Shaw D; Nottingham NIHR Respiratory BRC, University of Nottingham, Nottingham NG5 1PB, UK., Shinkins B; Leeds Institute of Health Sciences, University of Leeds, Leeds LS2 9TJ, UK., Szakmany T; Critical Care Directorate, Grange University Hospital, Aneurin Bevan University Health Board, Cwmbran NP44 2XJ, UK., Todd S; Tropical and Infectious Disease Unit, The Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool L7 8XP, UK., Thomas-Jones E; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4EP, UK., West RM; Leeds Institute of Health Sciences, University of Leeds, Leeds LS2 9TJ, UK., Carrol ED; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 3BX, UK., Sandoe JAT; Healthcare Associated Infection Group, Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.; Department of Microbiology, Old Medical School, Leeds Teaching Hospital NHS Trust Leeds, Leeds LS1 3EX, UK.
مؤلفون مشاركون: PEACH Study Group
المصدر: Methods and protocols [Methods Protoc] 2022 Nov 28; Vol. 5 (6). Date of Electronic Publication: 2022 Nov 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101720073 Publication Model: Electronic Cited Medium: Internet ISSN: 2409-9279 (Electronic) Linking ISSN: 24099279 NLM ISO Abbreviation: Methods Protoc Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2018]-
مستخلص: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although COVID-19 is a viral illness, many patients admitted to hospital are prescribed antibiotics, based on concerns that COVID-19 patients may experience secondary bacterial infections, and the assumption that they may respond well to antibiotic therapy. This has led to an increase in antibiotic use for some hospitalised patients at a time when accumulating antibiotic resistance is a major global threat to health. Procalcitonin (PCT) is an inflammatory marker measured in blood samples and widely recommended to help diagnose bacterial infections and guide antibiotic treatment. The PEACH study will compare patient outcomes from English and Welsh hospitals that used PCT testing during the first wave of the COVID-19 pandemic with those from hospitals not using PCT. It will help to determine whether, and how, PCT testing should be used in the NHS in future waves of COVID-19 to protect patients from antibiotic overuse. PEACH is a retrospective observational cohort study using patient-level clinical data from acute hospital Trusts and Health Boards in England and Wales. The primary objective is to measure the difference in antibiotic use between COVID-19 patients who did or did not have PCT testing at the time of diagnosis. Secondary objectives include measuring differences in length of stay, mortality, intensive care unit admission, and resistant bacterial infections between these groups.
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معلومات مُعتمدة: NIHR132254 National Institute for Health Research
فهرسة مساهمة: Keywords: COVID-19; antibiotics; antimicrobial stewardship; procalcitonin
تواريخ الأحداث: Date Created: 20221222 Latest Revision: 20221227
رمز التحديث: 20221227
مُعرف محوري في PubMed: PMC9786133
DOI: 10.3390/mps5060095
PMID: 36548137
قاعدة البيانات: MEDLINE
الوصف
تدمد:2409-9279
DOI:10.3390/mps5060095