دورية أكاديمية
أعرض في EDS

Apigenin protects from hepatorenal damage caused by lead acetate in rats.

التفاصيل البيبلوغرافية
العنوان: Apigenin protects from hepatorenal damage caused by lead acetate in rats.
المؤلفون: Fehaid A; Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Mansoura University, Dakahlia, Egypt., Al-Ghamdi MS; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia., Alzahrani KJ; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia., Theyab A; Department of Laboratory Medicine, Security Forces Hospital, Mecca, Saudi Arabia., Al-Amer OM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.; Genome and Biotechnology Unit, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia., Al-Shehri SS; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia., Algahtani M; Department of Laboratory Medicine, Security Forces Hospital, Mecca, Saudi Arabia., A Oyouni AA; Genome and Biotechnology Unit, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.; Department of Biology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., Alnfiai MM; Department of Information Technology, College of Computers and Information Technology, Taif University, Taif, Saudi Arabia., Aly MH; Internal Medicine Department, Security Forces Hospital, Mekkah, Saudi Arabia., Alsharif KF; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia., Albrakati A; Department of Human Anatomy, College of Medicine, Taif University, Taif, Saudi Arabia., Kassab RB; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.; Department of Biology, Faculty of Science and Arts, Al-Baha University, Al-Baha, Saudi Arabia., Althagafi HA; Department of Biology, Faculty of Science and Arts, Al-Baha University, Al-Baha, Saudi Arabia., Alharthi F; Department of Biology, College of Science, Taif University, Taif, Saudi Arabia., Abdel Moneim AE; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt., Lokman MS; Biology Department, College of Science and Humanities, Prince Sattam bin Abdul Aziz University, Alkharj, Saudi Arabia.
المصدر: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2023 Mar; Vol. 37 (3), pp. e23275. Date of Electronic Publication: 2022 Dec 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Wiley, c1998-
مواضيع طبية MeSH: Antioxidants*/pharmacology , Oxidative Stress*, Animals ; Rats ; Male ; Lead/toxicity ; Apigenin/pharmacology ; Rats, Wistar ; Liver/metabolism ; Anti-Inflammatory Agents/pharmacology ; Acetates/pharmacology
مستخلص: Exposure to lead (Pb) is associated with serious health problems including hepatorenal toxicity. Apigenin is a natural-sourced flavonoid with promising antioxidant and anti-inflammatory effects. In this research, we investigated the potential protective role of apigenin against lead acetate (PbAc)-induced hepatorenal damage. Thus, this experiment studied the exposure of male Wistar Albino rats to apigenin and/or PbAc and their effects in comparison to the control rats. Apigenin administration decreased the levels of Pb and prevented the histopathological deformations in liver and kidney tissues following PbAc exposure. This was confirmed by the normalized levels of liver and kidney function markers. Additionally, apigenin inhibited significantly oxidative reactions through upregulating Nrf2 and HO-1, and activating their downstreamed antioxidants accompanied by a marked depletion of pro-oxidants. Moreover, apigenin decreased the elevated pro-inflammatory cytokines and inhibited cell loss in liver and kidney tissues in response to PbAc intoxication in both tissues. The obtained results demonstrated that apigenin could be used to attenuate the molecular, biochemical, and histological alterations associated with Pb exposure due to its potent antioxidant, anti-inflammatory, and antiapoptotic effects.
(© 2022 Wiley Periodicals LLC.)
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معلومات مُعتمدة: Taif University; Researchers Supporting Program project number TUR
فهرسة مساهمة: Keywords: anti-inflammatory; antioxidant; apigenin; apoptosis; hepatorenal damage; lead
المشرفين على المادة: 0 (Antioxidants)
2P299V784P (Lead)
7V515PI7F6 (Apigenin)
0 (Anti-Inflammatory Agents)
0 (Acetates)
تواريخ الأحداث: Date Created: 20221223 Date Completed: 20230314 Latest Revision: 20230314
رمز التحديث: 20240628
DOI: 10.1002/jbt.23275
PMID: 36550699
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-0461
DOI:10.1002/jbt.23275