دورية أكاديمية
Protein Supplementation during Mid-Gestation Alters the Amino Acid Patterns, Hepatic Metabolism, and Maternal Skeletal Muscle Turnover of Pregnant Zebu Beef Cows.
العنوان: | Protein Supplementation during Mid-Gestation Alters the Amino Acid Patterns, Hepatic Metabolism, and Maternal Skeletal Muscle Turnover of Pregnant Zebu Beef Cows. |
---|---|
المؤلفون: | Meneses JAM; Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil.; Department of Veterinary Medicine and Animal Science, Universidad de Ciencias Aplicadas y Ambientales, Cartagena 130001, Bolivar, Colombia., Nascimento KB; Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil., Galvão MC; Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil., Ramírez-Zamudio GD; Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil., Gionbelli TRS; Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil., Ladeira MM; Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil., Duarte MS; Department of Animal Bioscience, University of Guelph, Guelph, ON N1G 2W1, Canada., Casagrande DR; Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil., Gionbelli MP; Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil. |
المصدر: | Animals : an open access journal from MDPI [Animals (Basel)] 2022 Dec 16; Vol. 12 (24). Date of Electronic Publication: 2022 Dec 16. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Molecular Diversity Preservation International Country of Publication: Switzerland NLM ID: 101635614 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2615 (Print) Linking ISSN: 20762615 NLM ISO Abbreviation: Animals (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2011- |
مستخلص: | From 100 to 200 days of gestation, 52 cows carrying male ( n = 30) or female ( n = 22) fetuses were assigned to CON (basal diet-5.5% of CP, n = 26) or SUP (basal diet + protein supplement [40% CP, 3.5 g/kg BW]-12% of CP, n = 26) treatments. Glucose concentrations decreased at 200 ( p ≤ 0.01; CON = 46.9 and SUP = 54.7 mg/dL) and 270 days ( p ≤ 0.05; CON = 48.4 and SUP = 53.3 mg/dL) for CON compared to SUP. The same pattern occurred for insulin ( p ≤ 0.01). At parturition, the NEFA concentration was greater ( p = 0.01, 0.10 vs. 0.08 mmol/L) for CON than for SUP. Total AA increased in SUP ( p ≤ 0.03) at mid- and late-gestation compared to CON. At 200 days, CON dams carrying females had less essential AA ( p = 0.01) than cows carrying males. The SUP dams had greater expressions of protein synthesis markers, namely eIf4E and GSK3β ( p ≤ 0.04), at day 200 and of MuFR1 (protein degradation marker, p ≤ 0.04) at parturition. Supplemented cows had higher hepatic pyruvate carboxylase expressions ( p = 0.02). Therefore, PS alleviates the restriction overload on maternal metabolism. Competing Interests: The authors declare no conflict of interest. |
References: | Comp Biochem Physiol B. 1987;88(3):719-25. (PMID: 3322661) Clin Chem. 1984 Mar;30(3):421-5. (PMID: 6697489) Am J Physiol. 1995 Apr;268(4 Pt 1):E705-11. (PMID: 7733270) Amino Acids. 2015 Jan;47(1):45-53. (PMID: 25399054) Animals (Basel). 2015 Aug 18;5(3):793-802. (PMID: 26479386) Placenta. 2013 Feb;34(2):119-26. (PMID: 23260227) Metabolites. 2021 Aug 28;11(9):. (PMID: 34564398) Mol Genet Metab. 2017 Dec;122(4):145-152. (PMID: 29033250) Reproduction. 2016 Jun;151(6):623-35. (PMID: 26980807) J Dairy Sci. 2019 Nov;102(11):10186-10201. (PMID: 31477295) Animals (Basel). 2022 Oct 20;12(20):. (PMID: 36290250) Br J Nutr. 1976 Nov;36(3):563-6. (PMID: 1009078) Trop Anim Health Prod. 2010 Oct;42(7):1471-9. (PMID: 20414721) J Dairy Sci. 2005 Aug;88(8):2938-48. (PMID: 16027208) Am J Physiol. 1983 May;244(5):E459-66. (PMID: 6846532) Animal. 2020 Sep;14(9):1867-1875. (PMID: 32172711) J Anim Sci. 2000 Oct;78(10):2737-44. (PMID: 11048941) J Anim Sci. 2020 Aug 18;98(Suppl 1):S175-S193. (PMID: 32810243) IUBMB Life. 2010 Dec;62(12):869-77. (PMID: 21171012) Aust J Biol Sci. 1987;40(4):365-77. (PMID: 3453037) Biochem J. 1972 Aug;128(5):1311-8. (PMID: 4345357) Animals (Basel). 2021 Mar 18;11(3):. (PMID: 33803518) Animals (Basel). 2022 Aug 21;12(16):. (PMID: 36009734) Cell Metab. 2019 Jun 4;29(6):1291-1305.e8. (PMID: 31006591) Mech Ageing Dev. 1989 May;48(2):179-89. (PMID: 2661933) Am J Clin Nutr. 2000 May;71(5 Suppl):1344S-52S. (PMID: 10799412) Nutr Res Rev. 2002 Dec;15(2):211-30. (PMID: 19087405) Endocrinology. 1999 Sep;140(9):3947-54. (PMID: 10465263) Exp Gerontol. 2003 Mar;38(3):267-78. (PMID: 12581790) Genetics. 2013 Nov;195(3):831-44. (PMID: 23979574) Biol Reprod. 2004 Sep;71(3):901-8. (PMID: 15140798) J Nutr. 2012 Jun;142(6):990-8. (PMID: 22513987) Metabolites. 2020 Jun 15;10(6):. (PMID: 32549362) J Dairy Sci. 2004 Oct;87(10):3105-24. (PMID: 15377589) J Anim Physiol Anim Nutr (Berl). 2018 Apr;102(2):545-556. (PMID: 29024128) Mol Cell Endocrinol. 2011 Jan 30;332(1-2):234-41. (PMID: 21056085) Hum Reprod. 1987 Aug;2(6):517-20. (PMID: 3667908) Science. 1973 Jan 5;179(4068):90-2. (PMID: 4682135) Biochem J. 2008 Aug 1;413(3):369-87. (PMID: 18613815) Br J Nutr. 1990 Sep;64(2):463-72. (PMID: 2223747) Am J Physiol. 1998 Dec;275(6):E942-50. (PMID: 9843735) Endocrinology. 2015 Oct;156(10):3422-34. (PMID: 26241064) PLoS One. 2014 Feb 03;9(2):e86169. (PMID: 24498270) J Dairy Sci. 2013 Oct;96(10):6423-39. (PMID: 23910547) Mol Metab. 2021 Nov;53:101257. (PMID: 34020084) |
معلومات مُعتمدة: | Grant#427276/2018-7; Grant#311883/2018-4 CNPq-Conselho Nacional de Desenvolvimento Científico e Tecnológico; Grant#001 CAPES-Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Grant# 465377/2014-9 FAPEMIG-Fundação de Amparo à Pesquisa de MG and INCT-CA-Instituto Nacional de Ciência e Tecnologia de Ciência Animal |
فهرسة مساهمة: | Keywords: amino acids; gene expression; gluconeogenesis; maternal nutrition; skeletal muscle |
تواريخ الأحداث: | Date Created: 20221223 Latest Revision: 20221225 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9774392 |
DOI: | 10.3390/ani12243567 |
PMID: | 36552487 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2076-2615 |
---|---|
DOI: | 10.3390/ani12243567 |