دورية أكاديمية
أعرض في EDS

Antiulcerogenic Potential of the Ethanolic Extract of Ceiba speciosa (A. St.-Hil.) Ravenna Evaluated by In Vitro and In Vivo Studies.

التفاصيل البيبلوغرافية
العنوان: Antiulcerogenic Potential of the Ethanolic Extract of Ceiba speciosa (A. St.-Hil.) Ravenna Evaluated by In Vitro and In Vivo Studies.
المؤلفون: Dörr JA; Graduate Program in Biotechnology (PPGBiotec), University of Vale do Taquari-Univates, Av. Avelino Talini, 171, Lajeado 95914-014, RS, Brazil., Majolo F; Graduate Program in Medicine Sciences (PPGCM), University of Vale do Taquari-Univates, Av. Avelino Talini, 171, Lajeado 95914-014, RS, Brazil., Bortoluzzi L; Graduate Program in Biotechnology (PPGBiotec), University of Vale do Taquari-Univates, Av. Avelino Talini, 171, Lajeado 95914-014, RS, Brazil., de Vargas EZ; Graduate Program in Biotechnology (PPGBiotec), University of Vale do Taquari-Univates, Av. Avelino Talini, 171, Lajeado 95914-014, RS, Brazil., Silva J; MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, Portugal., Pasini M; Graduate Program in Biotechnology (PPGBiotec), University of Vale do Taquari-Univates, Av. Avelino Talini, 171, Lajeado 95914-014, RS, Brazil., Stoll SN; Graduate Program in Biotechnology (PPGBiotec), University of Vale do Taquari-Univates, Av. Avelino Talini, 171, Lajeado 95914-014, RS, Brazil., da Rosa RL; Institute of Pharmacy, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil., Figueira MM; Graduate Program in Pharmaceutical Sciences, Natural Products Laboratory, Vila Velha University, Vila Velha 29102-920, ES, Brazil., Fronza M; Graduate Program in Pharmaceutical Sciences, Natural Products Laboratory, Vila Velha University, Vila Velha 29102-920, ES, Brazil., Beys-da-Silva WO; Institute of Pharmacy, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil., Martins A; MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, Portugal., Gaspar H; BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal., Pedrosa RP; MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, Portugal., Laufer S; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, D 72076 Tuebingen, Germany.; Tuübingen Center for Academic Drug Discovery-TÜCADD, Eberhard Karls Universität Tübingen, D 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls Universität Tübingen, D 72076 Tübingen, Germany., Goettert MI; Graduate Program in Biotechnology (PPGBiotec), University of Vale do Taquari-Univates, Av. Avelino Talini, 171, Lajeado 95914-014, RS, Brazil.; Graduate Program in Medicine Sciences (PPGCM), University of Vale do Taquari-Univates, Av. Avelino Talini, 171, Lajeado 95914-014, RS, Brazil.; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, D 72076 Tuebingen, Germany.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 09; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Anti-Ulcer Agents*/pharmacology , Ceiba*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Stomach Ulcer*/chemically induced , Stomach Ulcer*/drug therapy, Animals ; Humans ; Rats ; Antioxidants/pharmacology ; Carrageenan/adverse effects ; Tumor Necrosis Factor-alpha/metabolism ; Ulcer
مستخلص: Gastrointestinal diseases, such as peptic ulcers, are caused by a damage in the gastric mucosa provoked by several factors. This stomach injury is regulated by many inflammatory mediators and is commonly treated with proton-pump inhibitors, histamine H2 receptor blockers and antacids. However, various medicinal plants have demonstrated positive effects on gastric ulcer treatment, including plants of the Ceiba genus. The aim of this study was to evaluate the antiulcer and anti-inflammatory activities of the stem bark ethanolic extract of Ceiba speciosa (A. St.-Hil.) Ravenna. We performed a preliminary quantification of phenolic compounds by high-performance liquid chromatography-diode array detection (HPLC-DAD), followed by the prospection of other chemical groups through nuclear magnetic resonance (NMR) spectroscopy. A set of in vitro assays was used to evaluate the extract potential regarding its antioxidant activity (DPPH: 19.83 ± 0.34 µg/mL; TPC: 307.20 ± 6.20 mg GAE/g of extract), effects on cell viability and on the release of TNF-α in whole human blood. Additionally, in vivo assays were performed to evaluate the leukocyte accumulation and total protein quantification in carrageenan-induced air pouch, as well as the antiulcerogenic effect of the extract on an ethanol-induced ulcer in rats. The extract contains flavonoids and phenolic compounds, as well as sugars and quinic acid derivatives exhibiting potent antioxidant activity and low toxicity. The extract reduced the release of TNF-α in human blood and inhibited the activity of p38α (1.66 µg/mL), JAK3 (5.25 µg/mL), and JNK3 (8.34 µg/mL). Moreover, it reduced the leukocyte recruitment on the pouch exudate and the formation of edema, reverting the effects caused by carrageenan. The extract presented a significant prevention of ulcer formation and a higher reduction than the reference drug, Omeprazole. Therefore, C. speciosa extract has demonstrated relevant therapeutic potential for the treatment of gastric diseases, deserving the continuation of further studies to unveil the mechanisms of action of plant bioactive ingredients.
References: J Clin Med. 2019 Feb 03;8(2):. (PMID: 30717467)
Mol Cell Biochem. 2017 Jan;424(1-2):35-43. (PMID: 27704465)
Science. 2002 Dec 6;298(5600):1911-2. (PMID: 12471242)
Front Biosci. 1997 Jan 01;2:d12-26. (PMID: 9159205)
Vet World. 2018 May;11(5):627-635. (PMID: 29915501)
J Pharm Biomed Anal. 2012 Jul;66:349-51. (PMID: 22465233)
Int J Mol Med. 2013 Oct;32(4):971-7. (PMID: 23934131)
Nutrients. 2020 Jan 21;12(2):. (PMID: 31973186)
World J Gastroenterol. 2008 Jan 14;14(2):200-2. (PMID: 18186555)
Cell Physiol Biochem. 2015;36(6):2237-49. (PMID: 26279429)
Lancet. 2017 Aug 5;390(10094):613-624. (PMID: 28242110)
Biomedicine (Taipei). 2017 Dec;7(4):24. (PMID: 29130449)
J Ethnopharmacol. 2003 Feb;84(2-3):139-42. (PMID: 12648806)
Inflamm Res. 2011 Dec;60(12):1083-92. (PMID: 21964881)
Physiol Rev. 2008 Oct;88(4):1547-65. (PMID: 18923189)
Pharm Biol. 2013 Jan;51(1):100-30. (PMID: 22974340)
Nat Rev Immunol. 2015 Jun;15(6):362-74. (PMID: 26008591)
Arch Pharm (Weinheim). 2017 Nov;350(11):. (PMID: 28944566)
Evid Based Complement Alternat Med. 2019 Feb 17;2019:3546258. (PMID: 30906413)
Int J Med Sci. 2004;1(2):101-115. (PMID: 15912202)
J Nat Prod. 2012 Mar 23;75(3):311-35. (PMID: 22316239)
Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051)
BMC Complement Altern Med. 2017 Aug 4;17(1):388. (PMID: 28778164)
BMC Res Notes. 2012 Oct 02;5:546. (PMID: 23031266)
Methods Mol Biol. 2016;1360:123-48. (PMID: 26501907)
Gastroenterology. 2008 Jul;135(1):41-60. (PMID: 18549814)
Inflammation. 2012 Feb;35(1):321-31. (PMID: 21465277)
Nat Prod Res. 2019 Dec;33(23):3441-3444. (PMID: 29792358)
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. (PMID: 6606682)
Braz J Med Biol Res. 2002 May;35(5):523-34. (PMID: 12011936)
J Pharm Biomed Anal. 2011 Apr 28;55(1):236-40. (PMID: 21316174)
Acta Pharm. 2017 Dec 20;67(4):479-494. (PMID: 29337669)
Blood. 2007 May 15;109(10):4313-9. (PMID: 17255352)
Antioxidants (Basel). 2020 Aug 03;9(8):. (PMID: 32756302)
Avicenna J Phytomed. 2019 May-Jun;9(3):221-236. (PMID: 31143690)
Inflamm Res. 2016 Jul;65(7):533-42. (PMID: 26943648)
Cytotechnology. 2016 Oct;68(5):1909-23. (PMID: 27456242)
Molecules. 2017 Apr 25;22(5):. (PMID: 28441343)
Life Sci. 2019 May 1;224:88-94. (PMID: 30914317)
Int Immunopharmacol. 2001 Aug;1(8):1397-406. (PMID: 11515807)
Clin Exp Otorhinolaryngol. 2008 Sep;1(3):117-38. (PMID: 19434244)
Nat Clin Pract Gastroenterol Hepatol. 2006 Feb;3(2):80-9. (PMID: 16456574)
Obesity (Silver Spring). 2008 Sep;16(9):2081-7. (PMID: 18551111)
Int Immunopharmacol. 2012 Oct;14(2):209-16. (PMID: 22835426)
PLoS One. 2013;8(3):e58915. (PMID: 23516577)
Mol Carcinog. 2005 Jun;43(2):86-99. (PMID: 15791651)
Nutrients. 2018 Nov 02;10(11):. (PMID: 30400131)
Int Anesthesiol Clin. 2007 Spring;45(2):27-37. (PMID: 17426506)
J Ethnopharmacol. 2015 Dec 24;176:135-76. (PMID: 26497766)
Int J Mol Med. 2006 Mar;17(3):449-55. (PMID: 16465391)
J Immunol Methods. 1986 May 22;89(2):271-7. (PMID: 3486233)
Planta Med. 2017 Jun;83(9):770-777. (PMID: 28135738)
Mediators Inflamm. 2014;2014:352371. (PMID: 24771982)
Biomed Pharmacother. 2017 Dec;96:563-571. (PMID: 29032340)
Oncol Rep. 2013 Aug;30(2):925-32. (PMID: 23708932)
Medicines (Basel). 2015 Sep 08;2(3):251-286. (PMID: 28930211)
J Food Sci Technol. 2013 Aug;50(4):687-95. (PMID: 24425970)
معلومات مُعتمدة: 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; 420381/2018-0. National Council for Scientific and Technological Development; UIDP/04292/2020; UIDB/04292/2020 MARE-Marine and Environmental Sciences Center; UIDP/Multi/04046/2020; UIDB/04046/2020 BioSystems and Integrative Sciences Institute; 2019.00277.CBM FCT/DRI/CAPES; 2019 Univates
فهرسة مساهمة: Keywords: Ceiba genus; anti-inflammatory; antioxidant activity; gastrointestinal diseases; inflammation; peptic ulcer
المشرفين على المادة: 0 (Anti-Ulcer Agents)
0 (Antioxidants)
9000-07-1 (Carrageenan)
0 (Plant Extracts)
0 (Tumor Necrosis Factor-alpha)
تواريخ الأحداث: Date Created: 20221223 Date Completed: 20230103 Latest Revision: 20230103
رمز التحديث: 20230104
مُعرف محوري في PubMed: PMC9779658
DOI: 10.3390/ijms232415634
PMID: 36555275
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms232415634