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Novel Algorithm of Network Calcium Dynamics Analysis for Studying the Role of Astrocytes in Neuronal Activity in Alzheimer's Disease Models.

التفاصيل البيبلوغرافية
العنوان: Novel Algorithm of Network Calcium Dynamics Analysis for Studying the Role of Astrocytes in Neuronal Activity in Alzheimer's Disease Models.
المؤلفون: Mitroshina EV; Department of Neurotechnology, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia., Pakhomov AM; Department of Neurotechnology, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia.; Institute of Applied Physics RAS, 46 Ulyanov Street, Nizhny Novgorod 603950, Russia., Krivonosov MI; Department of Neurotechnology, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia.; Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia., Yarkov RS; Department of Neurotechnology, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia., Gavrish MS; Department of Neurotechnology, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia., Shkirin AV; Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilova St. 38, Moscow 119991, Russia.; Laser Physics Department, National Research Nuclear University MEPhI, Kashirskoe Sh. 31, Moscow 115409, Russia., Ivanchenko MV; Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia., Vedunova MV; Department of Neurotechnology, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 14; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Alzheimer Disease*/pathology, Humans ; Amyloid beta-Peptides/pharmacology ; Calcium/pharmacology ; Astrocytes ; Calcium, Dietary/pharmacology ; Neurons
مستخلص: Accumulated experimental data strongly suggest that astrocytes play an important role in the pathogenesis of neurodegeneration, including Alzheimer's disease (AD). The effect of astrocytes on the calcium activity of neuron-astroglia networks in AD modelling was the object of the present study. We have expanded and improved our approach's capabilities to analyze calcium activity. We have developed a novel algorithm to construct dynamic directed graphs of both astrocytic and neuronal networks. The proposed algorithm allows us not only to identify functional relationships between cells and determine the presence of network activity, but also to characterize the spread of the calcium signal from cell to cell. Our study showed that Alzheimer's astrocytes can change the functional pattern of the calcium activity of healthy nerve cells. When healthy nerve cells were cocultivated with astrocytes treated with Aβ42, activation of calcium signaling was found. When healthy nerve cells were cocultivated with 5xFAD astrocytes, inhibition of calcium signaling was observed. In this regard, it seems relevant to further study astrocytic-neuronal interactions as an important factor in the regulation of the functional activity of brain cells during neurodegenerative processes. The approach to the analysis of streaming imaging data developed by the authors is a promising tool for studying the collective calcium dynamics of nerve cells.
References: J Exp Med. 2018 Jun 4;215(6):1649-1663. (PMID: 29724785)
J Alzheimers Dis. 2016 Aug 1;54(1):135-48. (PMID: 27497478)
Front Pharmacol. 2019 Sep 27;10:1114. (PMID: 31611796)
Brain Res Brain Res Rev. 2000 Sep;33(2-3):199-227. (PMID: 11011066)
Trends Neurosci. 2017 Jun;40(6):358-370. (PMID: 28527591)
Nat Neurosci. 2021 Mar;24(3):312-325. (PMID: 33589835)
J Alzheimers Dis. 2015;46(2):423-9. (PMID: 25737042)
Cell Death Differ. 2016 Sep 1;23(9):1515-28. (PMID: 27104929)
Acta Neuropathol Commun. 2022 Mar 4;10(1):30. (PMID: 35246269)
J Neurosci Res. 2019 Apr;97(4):414-432. (PMID: 30604494)
Alzheimers Dement. 2018 Oct;14(10):1302-1312. (PMID: 30293574)
Adv Exp Med Biol. 2019;1175:273-324. (PMID: 31583592)
Cold Spring Harb Perspect Biol. 2019 Jul 1;11(7):. (PMID: 31110130)
Brain. 2020 Dec 5;143(11):3463-3476. (PMID: 33150361)
Neuron. 2008 Sep 25;59(6):932-46. (PMID: 18817732)
Ageing Res Rev. 2023 Jan;83:101775. (PMID: 36334910)
J Neurochem. 2009 Feb;108(3):533-44. (PMID: 19187090)
Front Aging Neurosci. 2022 Jul 06;14:946297. (PMID: 35928998)
Antioxid Redox Signal. 2018 Oct 20;29(12):1158-1175. (PMID: 29634342)
Oxid Med Cell Longev. 2015;2015:453901. (PMID: 26075035)
Curr Neuropharmacol. 2018;16(5):508-518. (PMID: 28730967)
PLoS One. 2012;7(10):e48034. (PMID: 23110166)
Expert Rev Neurother. 2015 Jan;15(1):83-105. (PMID: 25537424)
J Alzheimers Dis. 2018;64(s1):S567-S610. (PMID: 29843241)
Acta Neuropathol Commun. 2018 Oct 23;6(1):110. (PMID: 30352630)
Cell Calcium. 2021 May;95:102365. (PMID: 33610083)
Acta Neuropathol. 2016 Mar;131(3):323-45. (PMID: 26671410)
Front Cell Dev Biol. 2020 Jul 08;8:582. (PMID: 32733889)
Nat Commun. 2014 Nov 19;5:5422. (PMID: 25406732)
Lancet Neurol. 2014 Jun;13(6):614-29. (PMID: 24849862)
Biochem Biophys Res Commun. 2017 Feb 19;483(4):1005-1012. (PMID: 27545605)
PLoS One. 2012;7(12):e52056. (PMID: 23284867)
Curr Biol. 2017 Aug 7;27(15):2389-2396.e4. (PMID: 28756955)
Neurology. 2021 May 4;96(18):e2272-e2283. (PMID: 33722993)
Cell Calcium. 2018 Mar;70:87-94. (PMID: 28728834)
Front Neurosci. 2019 Jan 17;12:1026. (PMID: 30705616)
Prog Neurobiol. 2017 Aug;155:171-193. (PMID: 26209472)
Ann N Y Acad Sci. 1994 Dec 15;747:1-11. (PMID: 7847664)
Neurobiol Aging. 2011 Mar;32(3):539-40. (PMID: 19395124)
Front Integr Neurosci. 2016 Feb 29;10:7. (PMID: 26973475)
J Neurosci. 2006 Oct 4;26(40):10129-40. (PMID: 17021169)
Curr Alzheimer Res. 2011 Dec;8(8):853-9. (PMID: 21875410)
JAMA Neurol. 2013 Mar 1;70(3):304-10. (PMID: 23599928)
J Alzheimers Dis. 2016 Jul 22;54(1):207-21. (PMID: 27447424)
Curr Pharm Des. 2019;25(33):3506-3518. (PMID: 31604413)
Methods Mol Biol. 2018;1779:341-354. (PMID: 29886542)
J Neurosci. 2008 Jan 23;28(4):788-97. (PMID: 18216187)
Cell Calcium. 2010 Oct;48(4):225-31. (PMID: 20926134)
J Neurophysiol. 2007 Dec;98(6):3341-8. (PMID: 17913983)
Int Rev Cell Mol Biol. 2021;362:1-53. (PMID: 34253292)
Cell Death Dis. 2022 Mar 19;13(3):253. (PMID: 35306512)
Int J Mol Sci. 2020 Oct 26;21(21):. (PMID: 33114758)
J Biol Chem. 2011 Dec 30;286(52):45093-102. (PMID: 22081608)
Trends Neurosci. 2008 Sep;31(9):454-63. (PMID: 18675468)
Glia. 2019 Dec;67(12):2221-2247. (PMID: 31429127)
J Pharmacol Sci. 2003 May;92(1):28-34. (PMID: 12832852)
eNeuro. 2019 Mar 11;6(1):. (PMID: 30895220)
J Clin Invest. 2007 May;117(5):1230-9. (PMID: 17431506)
Dialogues Clin Neurosci. 2018 Dec;20(4):293-300. (PMID: 30936769)
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:2997-3003. (PMID: 34891875)
J Biol Chem. 2017 Jun 16;292(24):10153-10168. (PMID: 28476886)
PLoS One. 2007 Sep 19;2(9):e898. (PMID: 17878933)
Nat Neurosci. 2020 Jun;23(6):701-706. (PMID: 32341542)
معلومات مُعتمدة: 075-15-2022-293 Ministry of Science and Higher Education of the Russian Federation
فهرسة مساهمة: Keywords: Alzheimer’s disease; astrocytes; calcium activity; neuron–astroglia networks; β-amyloid
المشرفين على المادة: 0 (Amyloid beta-Peptides)
SY7Q814VUP (Calcium)
0 (Calcium, Dietary)
تواريخ الأحداث: Date Created: 20221223 Date Completed: 20221226 Latest Revision: 20221226
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9781291
DOI: 10.3390/ijms232415928
PMID: 36555569
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms232415928