دورية أكاديمية
أعرض في EDS

Mucin (MUC) Family Influence on Acute Lymphoblastic Leukemia in Cancer and Non-Cancer Native American Populations from the Brazilian Amazon.

التفاصيل البيبلوغرافية
العنوان: Mucin (MUC) Family Influence on Acute Lymphoblastic Leukemia in Cancer and Non-Cancer Native American Populations from the Brazilian Amazon.
المؤلفون: Alcântara AL; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Pastana LF; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Gellen LPA; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Vieira GM; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Dobbin EAF; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Silva TA; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Pereira EEB; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Rodrigues JCG; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Guerreiro JF; Human and Medical Genetics Laboratory, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66077-830, PA, Brazil., Fernandes MR; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Assumpção PP; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Cohen-Paes AN; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Santos SEBD; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil., Santos NPCD; Oncology Research Nucleus, Universidade Federal do Pará, Belém 66075-110, PA, Brazil.
المصدر: Journal of personalized medicine [J Pers Med] 2022 Dec 13; Vol. 12 (12). Date of Electronic Publication: 2022 Dec 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: The mucin (MUC) family includes several genes aberrantly expressed in multiple carcinomas and mediates diverse pathways essentials for oncogenesis, in both solid and hematological malignancies. Acute Lymphoblastic Leukemia (ALL) can have its course influenced by genetic variants, and it seems more frequent in the Amerindian population, which has been understudied. Therefore, the present work aimed to investigate the MUC family exome in Amerindian individuals from the Brazilian Amazon, in a sample containing healthy Native Americans (NAMs) and indigenous subjects with ALL, comparing the frequency of polymorphisms between these two groups. The population was composed of 64 Amerindians from the Brazilian Amazon, from 12 different isolated tribes, five of whom were diagnosed with ALL. We analyzed 16 genes from the MUC family and found a total of 1858 variants. We compared the frequency of each variant in the ALL vs. NAM group, which led to 77 variants with a significant difference and, among these, we excluded those with a low impact, resulting in 63 variants, which were distributed in nine genes, concentrated especially in MUC 19 ( n = 30) and MUC 3A ( n = 18). Finally, 11 new variants were found in the NAM population. This is the first work with a sample of native Americans with cancer, a population which is susceptible to ALL, but remains understudied. The MUC family seems to have an influence on the development of ALL in the Amerindian population and especially MUC19 and MUC3A are shown as possible hotspots. In addition, the 11 new variants found point to the need to have their clinical impact analyzed.
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فهرسة مساهمة: Keywords: ALL; Brazil; MUC family; native American populations; susceptibility
تواريخ الأحداث: Date Created: 20221223 Latest Revision: 20230123
رمز التحديث: 20230123
مُعرف محوري في PubMed: PMC9853325
DOI: 10.3390/jpm12122053
PMID: 36556273
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4426
DOI:10.3390/jpm12122053