دورية أكاديمية
أعرض في EDS

Complexation of a Polypeptide-Polyelectrolytes Bioparticle as a Biomaterial of Antibacterial Activity.

التفاصيل البيبلوغرافية
العنوان: Complexation of a Polypeptide-Polyelectrolytes Bioparticle as a Biomaterial of Antibacterial Activity.
المؤلفون: Ramirez CAB; Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04023-062, Brazil., Carriero MM; Department of Veterinary Medicine, University of Sao Paulo (USP), Pirassununga 13635-900, Brazil., Leomil FSC; Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04023-062, Brazil., Moro de Sousa RL; Department of Veterinary Medicine, University of Sao Paulo (USP), Pirassununga 13635-900, Brazil., de Miranda A; Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04023-062, Brazil., Mertins O; Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04023-062, Brazil., Mathews PD; Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04023-062, Brazil.
المصدر: Pharmaceutics [Pharmaceutics] 2022 Dec 08; Vol. 14 (12). Date of Electronic Publication: 2022 Dec 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The development of biomaterials to enable application of antimicrobial peptides represents a strategy of high and current interest. In this study, a bioparticle was produced by the complexation between an antimicrobial polypeptide and the biocompatible and biodegradable polysaccharides chitosan- N -arginine and alginate, giving rise to a colloidal polyelectrolytic complex of pH-responsive properties. The inclusion of the polypeptide in the bioparticle structure largely increases the binding sites of complexation during the bioparticles production, leading to its effective incorporation. After lyophilization, detailed evaluation of colloidal structure of redispersed bioparticles evidenced nano or microparticles with size, polydispersity and zeta potential dependent on pH and ionic strength, and the dependence was not withdrawn with the polypeptide inclusion. Significant increase of pore edge tension in giant vesicles evidenced effective interaction of the polypeptide-bioparticle with lipid model membrane. Antibacterial activity against Aeromonas dhakensis was effective at 0.1% and equal for the isolated polypeptide and the same complexed in bioparticle, which opens perspectives to the composite material as an applicable antibacterial system.
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معلومات مُعتمدة: 2021/00971-2 São Paulo Research Foundation; 2016/13362-4 São Paulo Research Foundation
فهرسة مساهمة: Keywords: Acustisoma longipes hemolymph; Aeromonas dhakensis; alginate; chitosan; giant vesicle electroporation; polypeptide antibacterial activity
تواريخ الأحداث: Date Created: 20221223 Latest Revision: 20221227
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9786851
DOI: 10.3390/pharmaceutics14122746
PMID: 36559240
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics14122746