دورية أكاديمية
أعرض في EDS

Polymeric Excipients in the Technology of Floating Drug Delivery Systems.

التفاصيل البيبلوغرافية
العنوان: Polymeric Excipients in the Technology of Floating Drug Delivery Systems.
المؤلفون: Blynskaya EV; V. V. Zakusov Research Institute of Pharmacology, 8 Baltiyskaya St., 125315 Moscow, Russia.; Institute of Biochemical Technology and Nanotechnology, Peoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia., Tishkov SV; V. V. Zakusov Research Institute of Pharmacology, 8 Baltiyskaya St., 125315 Moscow, Russia., Vinogradov VP; Institute of Biochemical Technology and Nanotechnology, Peoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia., Alekseev KV; V. V. Zakusov Research Institute of Pharmacology, 8 Baltiyskaya St., 125315 Moscow, Russia., Marakhova AI; Institute of Biochemical Technology and Nanotechnology, Peoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia., Vetcher AA; Institute of Biochemical Technology and Nanotechnology, Peoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.; Complementary and Integrative Health Clinic of Dr. Shishonin, 5 Yasnogorskaya St., 117588 Moscow, Russia.
المصدر: Pharmaceutics [Pharmaceutics] 2022 Dec 12; Vol. 14 (12). Date of Electronic Publication: 2022 Dec 12.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The combination of targeted transport and improvement of the release profile of the active pharmaceutical ingredient (API) is a current trend in the development of oral medicinal products (MP). A well-known way to implement this concept is to obtain floating gastroretentive delivery systems that provide a long stay of the dosage form (DF) on the surface of the stomach contents. The nomenclature of excipients (Es) of a polymeric nature used in the technology of obtaining floating drug delivery systems (FDDS) is discussed. Based on the data presented in research papers, the most widely used groups of polymers, their properties, and their purpose in various technological approaches to achieving buoyancy have been determined. In addition, ways to modify the release of APIs in these systems and the Es used for this are described. The current trends in the use of polymers in the technology of floating dosage forms (FDF) and generalized conclusions about the prospects of this direction are outlined.
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معلومات مُعتمدة: RUDN University Strategic Academic Leadership Program. RUDN
فهرسة مساهمة: Keywords: buoyancy; floating dosage forms; gastroretentive drug delivery systems; matrix formers; polymers
تواريخ الأحداث: Date Created: 20221223 Latest Revision: 20221227
رمز التحديث: 20221227
مُعرف محوري في PubMed: PMC9786229
DOI: 10.3390/pharmaceutics14122779
PMID: 36559272
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics14122779