دورية أكاديمية
أعرض في EDS

Systemic Metal Ion Concentrations in Patients With Hip and Knee Megaprostheses: A Prospective Cohort Study.

التفاصيل البيبلوغرافية
العنوان: Systemic Metal Ion Concentrations in Patients With Hip and Knee Megaprostheses: A Prospective Cohort Study.
المؤلفون: de Smidt KQ; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands., Spierenburg G; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands., Evenhuis RE; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands., Bosma SE; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands., van der Wal RJP; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands., Broekhuis D; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands., van de Sande MAJ; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands.
المصدر: Arthroplasty today [Arthroplast Today] 2022 Oct 21; Vol. 18, pp. 191-201.e1. Date of Electronic Publication: 2022 Oct 21 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101681808 Publication Model: eCollection Cited Medium: Print ISSN: 2352-3441 (Print) Linking ISSN: 23523441 NLM ISO Abbreviation: Arthroplast Today Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Maryland Heights, MO] : Elsevier, [2015]-
مستخلص: Background: Local tissue and serum metal ions have been shown to be elevated in some metal-on-metal and metal-on-polyethylene joint replacements. Local elevations have been linked to adverse local tissue reactions in some patients, and systemic elevation has been less commonly implicated cardiac and neurologic issues. Using a prospective study design, we aimed to identify the changes in serum metal ion levels after hip or knee megaprosthesis reconstruction. Furthermore, we will evaluate the occurrence of adverse effects and complications, possibly linked to metal ion elevation.
Methods: Fourteen consecutive patients receiving a Modular Universal Tumor Revision System megaprosthesis were enrolled. Blood samples were collected preoperatively and postoperatively to determine the serum ion concentrations of aluminum, chromium, cobalt, and silver. To evaluate the safety of the megaprostheses and the subsequently possible related (elevated) serum metal ion concentrations, all adverse effects and complications were registered until last outpatient clinic visit at the time of this study.
Results: Compared to the preoperative median serum concentrations, the postoperative median serum concentrations of chromium, silver, and cobalt increased 11-fold, 62-fold, and 64-fold, respectively. The median serum concentration of aluminum increased with 16%. Elevations were primarily noted in patients with knee prostheses. Eight patients had no adverse effects or complications during the period between preoperative and postoperative blood sampling. One adverse effect directly related to the serum metal ion concentrations, namely argyria, was observed.
Conclusions: This study documents significantly elevated concentrations of the metal ions, but only one adverse effect directly related to the metal ion concentrations was observed. Future studies are needed to further assess the impact of elevated metal ion levels after megaprostheses, specifically knee implants, which are metal-on-metal.
(© 2022 The Authors.)
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فهرسة مساهمة: Keywords: (MoM) Megaprostheses; Aluminum; Chromium; Cobalt; Serum metal ion concentrations; Silver
تواريخ الأحداث: Date Created: 20221223 Latest Revision: 20221224
رمز التحديث: 20221224
مُعرف محوري في PubMed: PMC9764025
DOI: 10.1016/j.artd.2022.08.006
PMID: 36561551
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-3441
DOI:10.1016/j.artd.2022.08.006