دورية أكاديمية
Cyclodextrin inclusion complex of a multi-component natural product by hot-melt extrusion.
| العنوان: | Cyclodextrin inclusion complex of a multi-component natural product by hot-melt extrusion. |
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| المؤلفون: | de Oliveira Nonato R; Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Setor Leste Universitário, Rua 240, Goiânia, GO, 74605-170, Brazil., Krawczyk-Santos AP; Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Setor Leste Universitário, Rua 240, Goiânia, GO, 74605-170, Brazil., Cardoso G; Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Setor Leste Universitário, Rua 240, Goiânia, GO, 74605-170, Brazil., Kogawa AC; School of Pharmacy, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil., Ricommini K; Pharmaceutical Application Laboratory, Ashland Specialty Ingredients, São Paulo, SP, Brazil., de Lima ÁAN; Pharmacy Department, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Heimfarth L; Department of Physiology (DFS), Laboratory of Neuroscience and Pharmacological Assays (LANEF), Universidade Federal de Sergipe, São Cristóvão, SE, Brazil., Quintans-Júnior LJ; Department of Physiology (DFS), Laboratory of Neuroscience and Pharmacological Assays (LANEF), Universidade Federal de Sergipe, São Cristóvão, SE, Brazil., Cunha-Filho M; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, Universidade de Brasilia, Brasília, DF, Brazil., Taveira SF; Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Setor Leste Universitário, Rua 240, Goiânia, GO, 74605-170, Brazil., Marreto RN; Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Setor Leste Universitário, Rua 240, Goiânia, GO, 74605-170, Brazil. ricardomarreto@ufg.br. |
| المصدر: | Drug delivery and translational research [Drug Deliv Transl Res] 2023 Apr; Vol. 13 (4), pp. 1140-1152. Date of Electronic Publication: 2022 Dec 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Springer |
| مواضيع طبية MeSH: | Cyclodextrins*/chemistry, 2-Hydroxypropyl-beta-cyclodextrin/chemistry ; Catechols ; Solubility |
| مستخلص: | This study aimed to investigate whether hot-melt extrusion (HME) processing can promote molecular encapsulation of a multi-component natural product composed of volatile and pungent hydrophobic substances (ginger oleoresin (OR)) with cyclodextrins. 6-Gingerol and 6-shogaol, the biomarkers of ginger OR, were quantified by HPLC. Phase-solubility studies were performed using β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) for ginger OR complexation. Solid complexes were then prepared by thermal (HME)- and solvent (slurry (SL))-based methods. Morphology, thermal behavior, solubility, in vitro dissolution, and in vivo anti-inflammatory activity were evaluated. HPβCD gave rise to AL-type complexes with ginger OR, whereas βCD led to materials with limited solubility. Ginger OR was complexed with HPβCD by HME without significant change in gingerol and shogaol content. Additionally, thermogravimetric analysis (TGA) suggested higher volatile retention in HME complexes than in SL ones. Shogaol and gingerol solubility and dissolution significantly increased from SL and HME complexes compared with ginger OR. In turn, 1:2 OR/HPβCD HME complex showed higher 6-shogaol solubility than SL, associated with a gradual release. The carrageenan-induced pleurisy test showed that the anti-inflammatory activity of ginger OR was maintained after complexation with HPβCD. The complexes significantly decrease the levels of IL-1β and inhibit cell migration. HME complex showed performance equivalent to the positive control and superior to the SL material. Taken together, these results indicate that HME can be useful for promoting the molecular encapsulation of complex natural products that contain volatile and thermolabile substances. HME complexes showed better in vivo and in vitro performance than complexes prepared using the solvent-based method. (© 2022. Controlled Release Society.) |
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| فهرسة مساهمة: | Keywords: Cyclodextrin; Ginger; Gingerols; Hot-melt extrusion; Oleoresin; Shogaols |
| المشرفين على المادة: | 83DNB5FIRF (shogaol) 0 (Cyclodextrins) 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin) 925QK2Z900 (gingerol) 0 (Catechols) |
| تواريخ الأحداث: | Date Created: 20221223 Date Completed: 20230306 Latest Revision: 20230324 |
| رمز التحديث: | 20230327 |
| DOI: | 10.1007/s13346-022-01280-w |
| PMID: | 36564661 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2190-3948 |
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| DOI: | 10.1007/s13346-022-01280-w |