دورية أكاديمية
Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes.
| العنوان: | Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes. |
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| المؤلفون: | Siddiqui K; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia., George TP; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Joy SS; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Alfadda AA; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.; Department of Medicine, College of Medicine, and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.; Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia. |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Dec 09; Vol. 13, pp. 1079725. Date of Electronic Publication: 2022 Dec 09 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/epidemiology , Diabetic Retinopathy*/etiology , Diabetic Retinopathy*/complications , Renal Insufficiency, Chronic*/complications , Renal Insufficiency, Chronic*/epidemiology , Hypertension*/complications, Humans ; Retrospective Studies ; Cross-Sectional Studies ; Risk Factors |
| مستخلص: | Background: Chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) is the major cause of end stage renal disease, characterized by proteinuria with a subsequent decline in glomerular filtration rate. Although hyperglycemia is the major risk factor for the development and progression of kidney disease among diabetic patients, many other risk factors also contribute to structural and functional changes in the kidneys. As recommended by Kidney Disease Improving Global Outcomes (KDIGO), CKD classification based on cause and severity, links to risk of adverse outcomes including mortality and kidney outcomes. Objective: The aim of this study is to investigate the involvement of risk factors associated with the severity of CKD among participants with longer duration of diabetes. This study also aims to find whether number of risk factors vary among risk of CKD progression categories based on KDIGO classification. Material and Methods: This cross-sectional study retrospectively selected 424 participants from type 2 diabetic cohort and categorized them based on the classifications for the diagnosis of kidney diseases in patients with diabetes, according to the KDIGO guidelines. Odds ratios and 95% CI of each risk factors according to severity of renal disease were determined. Results: Based on KDIGO classification, participants with type 2 diabetes (T2D) were categorized in to low risk (n=174); moderately increased risk (n=98); and high/very high risk (n=152). Type 2 diabetic participants with risk factors such as, hyperlipidemia, hypertension, DM duration ≥15 years and diabetic retinopathy showed a high/very high risk of CKD progression when compared with low-risk category. While T2D participants with risk factors such as, lack of exercise, hypertension, and diabetic retinopathy showed a moderately increased risk of CKD progression. In addition, participants with highest number of risk factors were significantly distributed among high/very high risk of CKD progression category. Conclusion: This study findings conclude that patients with T2DM and duration of ≥15 years, hyperlipidemia, hypertension and diabetic retinopathy have an increased prevalence of advanced CKD. In addition to this, increased number of risk factors could be an indicator of the severity of CKD in T2D. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Siddiqui, George, Joy and Alfadda.) |
| References: | Kidney Int Suppl (2011). 2013 Jan;3(1):19-62. (PMID: 25018975) BMJ. 2004 May 8;328(7448):1105. (PMID: 15096438) Ann Intern Med. 2018 Mar 20;168(6):422-430. (PMID: 29459980) Am J Kidney Dis. 2004 Nov;44(5):792-8. (PMID: 15492944) Ann Intern Med. 2009 May 5;150(9):604-12. (PMID: 19414839) J Nephropharmacol. 2015 Oct 09;5(1):49-56. (PMID: 28197499) Arq Bras Cardiol. 2019 Jun 06;112(5):577-587. (PMID: 31188964) Lancet. 2012 Nov 10;380(9854):1649-61. (PMID: 23013600) Diabetes Care. 2022 Dec 1;45(12):3075-3090. (PMID: 36189689) BMC Nephrol. 2021 Jun 16;22(1):223. (PMID: 34134654) Diabetol Metab Syndr. 2016 Jul 28;8:50. (PMID: 27471550) Ophthalmology. 1991 May;98(5 Suppl):786-806. (PMID: 2062513) PeerJ. 2021 Apr 19;9:e11070. (PMID: 33976959) Circulation. 2009 Dec 15;120(24):2438-47. (PMID: 19948976) Circulation. 2005 Mar 22;111(11):1370-6. (PMID: 15738353) BMC Res Notes. 2018 Aug 06;11(1):565. (PMID: 30081966) Diabetes Care. 2015 Jan;38 Suppl:S8-S16. (PMID: 25537714) J Nutr Metab. 2021 Aug 27;2021:6757916. (PMID: 34497725) Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2032-2045. (PMID: 28522654) BMJ. 1997 Mar 15;314(7083):783-8. (PMID: 9080995) Kidney Int. 2003 Jan;63(1):225-32. (PMID: 12472787) Trends Cardiovasc Med. 2020 Apr;30(3):160-164. (PMID: 31521481) Nat Rev Dis Primers. 2015 Jul 30;1:15018. (PMID: 27188921) PLoS One. 2014 Feb 21;9(2):e88956. (PMID: 24586457) Am J Kidney Dis. 2014 Feb;63(2 Suppl 2):S39-62. (PMID: 24461729) Curr Opin Nephrol Hypertens. 2021 Nov 1;30(6):538-546. (PMID: 34602599) Ann Saudi Med. 2018 Jan 3;38(1):46-56. (PMID: 29295969) Diabetes. 2009 Apr;58(4):773-95. (PMID: 19336687) Clin J Am Soc Nephrol. 2008 Nov;3(6):1660-8. (PMID: 18922983) BMC Nephrol. 2016 Nov 22;17(1):187. (PMID: 27876008) J Prim Care Community Health. 2021 Jan-Dec;12:21501327211048556. (PMID: 34634970) Am J Nephrol. 2009;29(3):213-21. (PMID: 18797164) Adv Chronic Kidney Dis. 2014 May;21(3):260-6. (PMID: 24780453) Diabet Med. 2015 Oct;32(10):1342-5. (PMID: 25943475) Ann Intern Med. 2013 Jun 4;158(11):825-30. (PMID: 23732715) |
| فهرسة مساهمة: | Keywords: diabetic kidney disease (DKD); diabetic nephropathy; high prevalence of diabetes; longer duration of diabetes; risk factors |
| تواريخ الأحداث: | Date Created: 20221226 Date Completed: 20221227 Latest Revision: 20230127 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9780388 |
| DOI: | 10.3389/fendo.2022.1079725 |
| PMID: | 36568108 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
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| DOI: | 10.3389/fendo.2022.1079725 |