دورية أكاديمية
أعرض في EDS

Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging.

التفاصيل البيبلوغرافية
العنوان: Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging.
المؤلفون: Singh S; Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA., Giammanco G; Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA., Hu CH; Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA., Bush J; Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA., Cordova LS; Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA., Lawrence DJ; PhotoSound Technologies Inc., Houston, TX 77036, USA., Moran JL; Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA.; Department of Mechanical Engineering, George Mason University, Fairfax, VA 22030, USA., Chitnis PV; Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA.; Center for Adaptive Systems for Brain-body Interactions, George Mason University, Fairfax, VA 22030, USA., Veneziano R; Department of Bioengineering, George Mason University, Fairfax, VA 22030, USA.; Institute for Advanced Biomedical Research, George Mason University, Manassas, VA 20110, USA.
المصدر: Photoacoustics [Photoacoustics] 2022 Dec 11; Vol. 29, pp. 100437. Date of Electronic Publication: 2022 Dec 11 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101622604 Publication Model: eCollection Cited Medium: Print ISSN: 2213-5979 (Print) Linking ISSN: 22135979 NLM ISO Abbreviation: Photoacoustics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Munich : Elsevier GmbH
مستخلص: Near-infrared photoacoustic imaging (NIR-PAI) combines the advantages of optical and ultrasound imaging to provide anatomical and functional information of tissues with high resolution. Although NIR-PAI is promising, its widespread use is hindered by the limited availability of NIR contrast agents. J-aggregates (JA) made of indocyanine green dye (ICG) represents an attractive class of biocompatible contrast agents for PAI. Here, we present a facile synthesis method that combines ICG and ICG-azide dyes for producing contrast agents with tunable size down to 230 nm and direct functionalization with targeting moieties. The ICG-JA platform has a detectable PA signal in vitro that is two times stronger than whole blood and high photostability. The targeting ability of ICG-JA was measured in vitro using HeLa cells. The ICG-JA platform was then injected into mice and in vivo NIR-PAI showed enhanced visualization of liver and spleen for 90 min post-injection with a contrast-to-noise ratio of 2.42.
Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Shrishti Singh has patent Provisional Patent pending to George Mason University. Parag V. Chitnis has patent Provisional patent pending to George Mason University. Remi Veneziano has patent Provisional patent pending to George Mason University.
(© 2022 The Authors.)
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فهرسة مساهمة: Keywords: Contrast agent; Imaging probe; Indocyanine green (ICG); J-aggregates (JA); Photoacoustic imaging (PAI)
تواريخ الأحداث: Date Created: 20221226 Latest Revision: 20221227
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9772562
DOI: 10.1016/j.pacs.2022.100437
PMID: 36570471
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-5979
DOI:10.1016/j.pacs.2022.100437