دورية أكاديمية
Correlation of response to subthalamic deep brain stimulation in Parkinson's disease patients with striatal dopamine transporter density on 99mtc-TRODAT-1 SPECT.
| العنوان: | Correlation of response to subthalamic deep brain stimulation in Parkinson's disease patients with striatal dopamine transporter density on 99mtc-TRODAT-1 SPECT. |
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| المؤلفون: | Ghaedian T; Nuclear Medicine and Molecular Imaging Research Center, Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Razmkon A; Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran., Kalhor L; Department of Nuclear Medicine, Alborz University of Medical Sciences, Karaj, Iran., Ostovan VR; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Yousefi O; Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran., Rezaei R; Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran., Hossein-Tehrani MR; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Rakhsha A; Department of Neurosurgery, School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran. |
| المصدر: | Neurological research [Neurol Res] 2023 Jun; Vol. 45 (6), pp. 505-509. Date of Electronic Publication: 2022 Dec 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 7905298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-1328 (Electronic) Linking ISSN: 01616412 NLM ISO Abbreviation: Neurol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Abingdon : Taylor & Francis Original Publication: New York, Crane, Russak. |
| مواضيع طبية MeSH: | Parkinson Disease*/diagnostic imaging , Parkinson Disease*/therapy , Deep Brain Stimulation*/methods, Humans ; Dopamine Plasma Membrane Transport Proteins ; Treatment Outcome ; Levodopa ; Tomography, Emission-Computed, Single-Photon |
| مستخلص: | Background: Deep brain stimulation (DBS) is a surgical approach with electrical stimulation of certain parts of the brain, which reduce Parkinson's disease (PD) symptoms. Since the loss of dopaminergic neurons in the substantia nigra is the main pathophysiology of PD, we aimed to evaluate the association of response to DBS with preoperative dopamine transporter density (DAT) and its postoperative changes in PD patients who underwent the bilateral implantation of the electrodes in the subthalamic nucleus (STN). Method: A prospective evaluation of Parkinson's disease patients who underwent STN-DBS for 2 years was done. 99mTc-TRODAT-1 single-photon emission computed tomography (SPECT) scan and assessment of PD using unified Parkinson's disease rating scale (UPDRS) III were performed in both pre- and post-operation states. The correlation of response to DBS after 6 months was assessed with baseline findings and postoperative changes of 99mTc-TRODAT-1 SPECT parameters. Results: Compared to the preoperative state, UPDRS III scores and Levodopa equivalent daily dose (LEDD) were significantly decreased after DBS. However, in 17 patients who underwent both pre-and post-operative 99mTc-TRODAT-1 SPECT, no significant change was seen in any quantitative parameters, including right and left striatal-binding ratio (SBR) as well as striatal asymmetry index (SAI). No significant correlation was also found between the percent of UPDRS III change after DBS and values of preoperative SBRs. The percentage of LEDD reduction also showed no significant correlation with the preoperative state of 99 m-TRODAT-1 SPECT. Conclusion: Our results showed that the mechanism of DBS action is not accompanied by short-term compensation of DAT in basal ganglia in severely advanced PD. |
| فهرسة مساهمة: | Keywords: Parkinson disease; SPECT; Subthalamic nucleus; deep brain stimulation; dopamine transporter density |
| المشرفين على المادة: | 0 (Dopamine Plasma Membrane Transport Proteins) 46627O600J (Levodopa) |
| تواريخ الأحداث: | Date Created: 20221227 Date Completed: 20230505 Latest Revision: 20230505 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/01616412.2022.2162219 |
| PMID: | 36573915 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1743-1328 |
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| DOI: | 10.1080/01616412.2022.2162219 |