دورية أكاديمية
Elucidation of protective effects of oxime derivatives against cisplatin-induced cytotoxicity in LLC-PK1 kidney cells.
| العنوان: | Elucidation of protective effects of oxime derivatives against cisplatin-induced cytotoxicity in LLC-PK1 kidney cells. |
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| المؤلفون: | Lee D; College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea., Hyuk Lee S; Natural Product Research Center, Korea Institute of Science and Technology, Saimdang-ro 679, Gangneung 25451, Republic of Korea., Lee H; College of Dentistry, Gangneung Wonju National University, Gangneung 25457, Republic of Korea., Choi YK; College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea., Sung Kang K; College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea. Electronic address: kkang@gachon.ac.kr., Wook Lee J; Natural Product Research Center, Korea Institute of Science and Technology, Saimdang-ro 679, Gangneung 25451, Republic of Korea. Electronic address: jwlee5@kist.re.kr. |
| المصدر: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jan 15; Vol. 80, pp. 129114. Date of Electronic Publication: 2022 Dec 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1991- |
| مواضيع طبية MeSH: | Cisplatin*/pharmacology , Kidney*/metabolism, Animals ; Swine ; LLC-PK1 Cells ; JNK Mitogen-Activated Protein Kinases/metabolism ; Apoptosis |
| مستخلص: | This study aimed to explore the renoprotective effects of oxime derivatives against cisplatin-mediated cell death in LLC-PK1 porcine kidney epithelial cells. Treatment with compounds 161-A and 161-F improved cisplatin-mediated LLC-PK1 cell damage and increased cell viability by more than 80% of the control value when compared with that of cisplatin-treated cells. In addition, 161-A and 161-F reduced cisplatin-induced apoptosis. Analysis of the molecular mechanisms underlying the effects exerted by these compounds revealed that treatment with 161-A and 161-B inhibited the protein expression of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) and cleaved caspase-3 in cisplatin-treated LLC-PK1 cells. Thus, these findings provide in vitro scientific evidence that oxime derivatives may be useful as pharmacological candidates for the prevention of cisplatin-mediated nephrotoxicity. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Apoptosis; LLC-PK1 cells; Nephrotoxicity cisplatin; Oxime derivatives |
| المشرفين على المادة: | Q20Q21Q62J (Cisplatin) EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases) |
| تواريخ الأحداث: | Date Created: 20221227 Date Completed: 20230123 Latest Revision: 20230201 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bmcl.2022.129114 |
| PMID: | 36574854 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3405 |
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| DOI: | 10.1016/j.bmcl.2022.129114 |