التفاصيل البيبلوغرافية
| العنوان: |
Development of a Novel Positive Pressure Protective Suit for a Biosafety Level 4 Laboratory in Japan. |
| المؤلفون: |
Shichinohe S; National Research Center for the Control and Prevention of Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan.; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Japan., Sakurai Y; National Research Center for the Control and Prevention of Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan.; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan., Hayasaka D; National Research Center for the Control and Prevention of Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan., Yamada E; National Research Center for the Control and Prevention of Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan., Shinohara K; Faculty of Textile Science and Technology, Shinshu University, Japan., Kurosaki Y; National Research Center for the Control and Prevention of Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan., Nakajima K; National Research Center for the Control and Prevention of Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan. |
| المصدر: |
Japanese journal of infectious diseases [Jpn J Infect Dis] 2023 Mar 24; Vol. 76 (2), pp. 162-166. Date of Electronic Publication: 2022 Dec 28. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: National Institute of Infectious Diseases Country of Publication: Japan NLM ID: 100893704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1884-2836 (Electronic) Linking ISSN: 13446304 NLM ISO Abbreviation: Jpn J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Tokyo, Japan : National Institute of Infectious Diseases, [1999- |
| مواضيع طبية MeSH: |
Laboratories* , Containment of Biohazards*, Humans ; Japan |
| مستخلص: |
Biosafety level 4 (BSL-4) laboratories are necessary to study microorganisms that are highly pathogenic to humans and have no prevention or therapeutic measures. Currently, most BSL-4 facilities have suit-type laboratories to conduct experiments on highly pathogenic microorganisms. In 2021, the first Japanese suit-type BSL-4 laboratory was constructed at Nagasaki University. Positive pressure protection suit (PPPS) is a primary barrier that protects and isolates laboratory workers from pathogens and the laboratory environment. Here, we developed a novel PPPS originally designed to be used in the Nagasaki BSL-4 laboratory. We modified several parts of a domestic chemical protective suit, including its front face shield, cuff, and air supply hose, for safe handling of microbiological agents. The improved suit, PS-790BSL4-AL, showed resistance to several chemicals, including quaternary ammonium disinfectant, and did not show any permeation against blood and phages. To validate the suit's integrity, we also established an airtight test that eliminated individual differences for quantitative testing. In conclusion, our developed suit performs sufficiently as a primary barrier and allows for the safe handling of pathogens in our new BSL-4 laboratory. |
| فهرسة مساهمة: |
Keywords: BSL-4; biorisk management; maximum containment laboratory; personal protective equipment; positive pressure protective suits |
| تواريخ الأحداث: |
Date Created: 20221227 Date Completed: 20230328 Latest Revision: 20230328 |
| رمز التحديث: |
20230328 |
| DOI: |
10.7883/yoken.JJID.2022.475 |
| PMID: |
36575023 |
| قاعدة البيانات: |
MEDLINE |
