دورية أكاديمية
Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures.
| العنوان: | Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures. |
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| المؤلفون: | Minarrieta L; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Canada., Godoy GJ; Institute of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany., Velazquez LN; Institute of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany., Ghorbani P; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Canada., Sparwasser T; Institute of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center Mainz, Mainz, Germany., Berod L; Institute of Molecular Medicine, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center Mainz, Mainz, Germany. |
| المصدر: | European journal of immunology [Eur J Immunol] 2023 Feb; Vol. 53 (2), pp. e2149691. Date of Electronic Publication: 2022 Dec 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Weinheim : Wiley-VCH Original Publication: Weinheim, Verlag Chemie GmbH. |
| مواضيع طبية MeSH: | Granulocyte-Macrophage Colony-Stimulating Factor*/metabolism , Nitric Oxide*/metabolism, Mice ; Animals ; Dendritic Cells/metabolism ; Cell Differentiation ; Mice, Inbred C57BL |
| مستخلص: | The CD11c + MHCII + compartment within GM-CSF cultures consists of a MHCII low CD11b high population (GM-Macs) and a MHCII high CD11b int population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation inhibiting mitochondrial respiration (OXPHOS) while promoting glycolytic metabolism in GM-DCs, which naturally do not express iNOS. (© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.) |
| References: | Minarrieta, L., Velasquez, L. N., Sparwasser, T. and Berod, L., Dendritic cell metabolism: moving beyond in vitro-culture-generated paradigms. Curr. Opin. Biotechnol. 2021. 68: 202-212. Everts, B., Amiel, E., Huang, S. C., Smith, A. M., Chang, C. H., Lam, W. Y., Redmann, V. et al., TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat. Immunol. 2014. 15: 323-332. Stuve, P., Minarrieta, L., Erdmann, H., Arnold-Schrauf, C., Swallow, M., Guderian, M., Krull, F. et al., De novo fatty acid synthesis during mycobacterial infection is a prerequisite for the function of highly proliferative T cells, but not for dendritic cells or macrophages. Front. Immunol. 2018. 9: 495. Everts, B., Amiel, E., van der Windt, G. J., Freitas, T. C., Chott, R., Yarasheski, K. E., Pearce, E. L. et al., Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 2012. 120: 1422-1431. Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R. et al., Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 2010. 115: 4742-4749. Stuehr, D. J. and Nathan, C. F., Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 1989. 169: 1543-1555. Helft, J., Bottcher, J., Chakravarty, P., Zelenay, S., Huotari, J., Schraml, B. U., Goubau, D. et al., GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c(+)MHCII(+) macrophages and dendritic cells. Immunity 2015. 42: 1197-1211. Wu, D., Sanin, D. E., Everts, B., Chen, Q., Qiu, J., Buck, M. D., Patterson, A. et al., Type 1 interferons induce changes in core metabolism that are critical for immune function. Immunity 2016. 44: 1325-1336. Wculek, S. K., Khouili, S. C., Priego, E., Heras-Murillo, I. and Sancho, D., Metabolic control of dendritic cell functions: digesting information. Front. Immunol. 2019. 10: 775. Lawless, S. J., Kedia-Mehta, N., Walls, J. F., McGarrigle, R., Convery, O., Sinclair, L. V., Navarro, M. N. et al., Glucose represses dendritic cell-induced T cell responses. Nat. Commun. 2017. 8: 15620. Postat, J., Olekhnovitch, R., Lemaitre, F. and Bousso, P., A metabolism-based quorum sensing mechanism contributes to termination of inflammatory responses. Immunity 2018. 49: 654-665.e5. |
| فهرسة مساهمة: | Keywords: DC metabolism; GM-CSF; dendritic cells; in vitro culture; nitric oxide |
| المشرفين على المادة: | 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor) 31C4KY9ESH (Nitric Oxide) |
| تواريخ الأحداث: | Date Created: 20221228 Date Completed: 20230203 Latest Revision: 20230316 |
| رمز التحديث: | 20230320 |
| DOI: | 10.1002/eji.202149691 |
| PMID: | 36577714 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1521-4141 |
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| DOI: | 10.1002/eji.202149691 |