دورية أكاديمية
أعرض في EDS

Antimalarial activity of the hydroalcoholic crude extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves against Plasmodium berghei in mice.

التفاصيل البيبلوغرافية
العنوان: Antimalarial activity of the hydroalcoholic crude extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves against Plasmodium berghei in mice.
المؤلفون: Tadege G; School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Southwest, Ethiopia., Kahssay SW; School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Southwest, Ethiopia., Fisseha N; School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Southwest, Ethiopia., Abebe D; Department of Pharmacy, College of Health Sciences, Debre Markos University, Northwest, Ethiopia., Nureye D; School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Southwest, Ethiopia.
المصدر: Heliyon [Heliyon] 2022 Dec 10; Vol. 8 (12), pp. e12045. Date of Electronic Publication: 2022 Dec 10 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Ethnopharmacological Relevance: In Ethiopia, the indigenous medicinal plant Commelina latifolia Hochst. ex C.B. Clarke leaves are used to treat malaria and wounds.
Aim of the Study: In this work, the antiplasmodial activity of Commelina latifolia crude leaf extract and solvent fractions against Plasmodium berghei -infected mice was investigated.
Materials and Methods: 80% methanol was used to extract the leaves of C. latifolia , and the crude extract was fractionated using chloroform, pure methanol, and distilled water. All test compounds were undergone an acute oral toxicity test before being put through Peter's 4-day suppressive test to see if they have antiplasmodial activity. The hydroalcoholic crude extract and chloroform fraction were additionally assessed for antimalarial activity using curative and prophylactic tests in P. berghei- infected laboratory mice.
Results: All of the tested crude extracts were safe at a dose of 2000 mg/kg. At 400 mg/kg dose both the 80% methanol extract and chloroform fraction exhibited antimalarial activity with parasitemia suppression values of 86.31%, and 76.56% in the four-day suppressive test, 81.97% and 72.05% in Rane's test, and 69.05% and 62.88% in the prophylactic test, respectively.
Conclusion: Collectively, the oral dose of Commelina latifolia is safe, and reveals promising antimalarial activity. The findings backed up the utilization of the plant in traditional medicine to treat malaria.
Competing Interests: The authors declare no conflict of interest.
(© 2022 The Author(s).)
References: Iran J Parasitol. 2012;7(4):62-74. (PMID: 23323093)
Molecules. 2010 Dec 28;16(1):107-18. (PMID: 21189459)
J Ethnopharmacol. 2012 Jan 6;139(1):221-7. (PMID: 22101085)
Exp Parasitol. 1965 Aug;17(1):80-9. (PMID: 5843289)
SAGE Open Med. 2019 May 13;7:2050312119849766. (PMID: 31205692)
Int J Parasitol Drugs Drug Resist. 2022 Apr;18:43-51. (PMID: 35092864)
Blood Transfus. 2010 Oct;8(4):248-54. (PMID: 20967165)
Chem Immunol. 2002;80:204-28. (PMID: 12058640)
Malar J. 2017 Jan 13;16(1):25. (PMID: 28086782)
J Ethnopharmacol. 2005 May 13;99(1):137-43. (PMID: 15848033)
Am J Bot. 2009 Jul;96(7):1236-44. (PMID: 21628272)
BMC Complement Altern Med. 2015 Dec 23;15:448. (PMID: 26698300)
Nat Rev Drug Discov. 2004 Jun;3(6):509-20. (PMID: 15173840)
J Ethnopharmacol. 2001 Sep;77(1):91-8. (PMID: 11483383)
BMC Complement Altern Med. 2014 Mar 01;14:79. (PMID: 24580778)
BMC Complement Altern Med. 2017 Jan 5;17(1):13. (PMID: 28056932)
Infect Dis Poverty. 2018 Nov 05;7(1):103. (PMID: 30392470)
Vaccine. 2005 Oct 25;23(44):5196-203. (PMID: 16043270)
J Ethnopharmacol. 2006 Jan 16;103(2):236-40. (PMID: 16171960)
Antimicrob Agents Chemother. 2009 Apr;53(4):1468-75. (PMID: 19188392)
J Exp Pharmacol. 2020 Sep 07;12:313-323. (PMID: 32982487)
Ann Trop Med Parasitol. 1970 Jun;64(2):209-22. (PMID: 4992592)
Heliyon. 2021 Nov 24;7(11):e08457. (PMID: 34901504)
PLoS One. 2012;7(9):e45906. (PMID: 23029306)
J Med Chem. 2012 Jan 12;55(1):291-6. (PMID: 22128829)
Malar J. 2019 Apr 24;18(1):145. (PMID: 31014319)
J Exp Pharmacol. 2019 Dec 16;11:121-134. (PMID: 31908546)
فهرسة مساهمة: Keywords: Antimalarial activity; Commelina latifolia; Plasmodium berghei; Traditional medicine
تواريخ الأحداث: Date Created: 20221229 Latest Revision: 20230103
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9791320
DOI: 10.1016/j.heliyon.2022.e12045
PMID: 36578416
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2022.e12045