دورية أكاديمية
أعرض في EDS

METTL14 Regulates Intestine Cellular Senescence through m 6 A Modification of Lamin B Receptor.

التفاصيل البيبلوغرافية
العنوان: METTL14 Regulates Intestine Cellular Senescence through m 6 A Modification of Lamin B Receptor.
المؤلفون: Zhang Z; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China.; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Xue M; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China.; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Chen J; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China., Wang Z; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China.; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Ju F; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China., Ni J; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China., Sun J; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China., Wu H; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Zheng H; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Lou Z; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Zhang Y; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China., Yang X; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Chen S; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China., Xi Y; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Wang L; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China.; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Dec 19; Vol. 2022, pp. 9096436. Date of Electronic Publication: 2022 Dec 19 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Drosophila melanogaster*/genetics , Drosophila melanogaster*/metabolism , Cellular Senescence*/genetics, Humans ; Mice ; Animals ; Receptors, Cytoplasmic and Nuclear/genetics ; Phenotype ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Lamin B Receptor
مستخلص: N-6-Methyladenosine (m 6 A) modification is involved in multiple biological processes including aging. However, the regulation of m 6 A methyltransferase-like 14 (METTL14) in aging remains unclear. Here, we revealed that the level of m 6 A modification and the expression of METTL14 were particularly decreased in the intestine of aged mice as compared to young mice. Similar results were confirmed in Drosophila melanogaster . Knockdown of Mettl14 in Drosophila resulted in a short lifespan, associated disrupted intestinal integrity, and reduced climbing ability. In human CCD-18Co cells, knockdown of METTL14 accelerated cellular senescence, and the overexpression of METTL14 rescued senescent phenotypes. We also identified the lamin B receptor (LBR) as a target gene for METTL14-mediated m 6 A modification. Knockdown of METTL14 decreased m 6 A level of LBR, resulted in LBR mRNA instability, and thus induced cellular senescence. Our findings suggest that METTL14 plays an essential role in the m 6 A modification-dependent aging process via the regulation of LBR and provides a potential target for cellular senescence.
Competing Interests: No potential conflicts of interest were disclosed.
(Copyright © 2022 Zizhen Zhang et al.)
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المشرفين على المادة: 0 (Receptors, Cytoplasmic and Nuclear)
EC 2.1.1.- (Methyltransferases)
EC 2.1.1.- (METTL14 protein, human)
تواريخ الأحداث: Date Created: 20221229 Date Completed: 20221230 Latest Revision: 20231213
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9792243
DOI: 10.1155/2022/9096436
PMID: 36578521
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2022/9096436