دورية أكاديمية
The role of lncRNA CERS6-AS1 in cancer and its molecular mechanisms: A systematic review and meta-analysis.
| العنوان: | The role of lncRNA CERS6-AS1 in cancer and its molecular mechanisms: A systematic review and meta-analysis. |
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| المؤلفون: | Rastad H; Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran., Samimisedeh P; Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran., Alan MS; Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran., Afshar EJ; Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran., Ghalami J; Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran; The Clinical Research Development units of Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran., Hashemnejad M; Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran., Alan MS; Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address: m_seifi2012@yahoo.com. |
| المصدر: | Pathology, research and practice [Pathol Res Pract] 2023 Jan; Vol. 241, pp. 154245. Date of Electronic Publication: 2022 Dec 14. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Gustav Fischer Verlag Original Publication: Stuttgart, New York, Fischer. |
| مواضيع طبية MeSH: | RNA, Long Noncoding*/genetics , MicroRNAs* , Liver Neoplasms*/genetics, Humans ; Prognosis ; Lymphatic Metastasis ; Gene Expression Regulation, Neoplastic/genetics ; Membrane Proteins/genetics ; Sphingosine N-Acyltransferase/genetics |
| مستخلص: | Background: LncRNAs have the potential to play a regulatory role in different processes of cancer development and progression. We conducted a systematic review and meta-analysis of evidence on the clinical significance and prognostic value of lncRNA CERS6-AS1 in cancer. Methods: This systematic review was conducted following PRISMA guidelines. Medline and Embase databases were searched using the relevant key terms covering lncRNA CERS6-AS1 and cancer. We pooled the estimated effect sizes and their 95 % confidence interval (CI) using random-effects models in STATA 16.0 (StataCorp, College Station, TX, USA). Results: Eleven articles on pancreatic, colorectal, gastric, papillary thyroid, breast, and hepatocellular cancers fulfilled our eligibility criteria. Studies consistently found that lncRNA CERS6-AS1 expression is upregulated in all assessed cancers. Based on our meta-analysis, its aberrant expression was directly associated with unfavorable clinical outcomes, including higher stage (pooled Odds ratios (95 % CI): 3.15 (2.01-4.93; I 2 = 0.0 %), tumor size (1.97 (1.27-3.05; I 2 = 37.8 %), lymph node metastasis (6.48 (4.01-10.45; I 2 = 0.40 %), and poor survival (Pooled log-rank test P-value < 0.001) in patients. Regarding potential mechanisms, functional studies revealed that LncRNA CERS6-AS1 is involved in cancer growth mainly by sponging miRNAs and regulating their downstream targets. Conclusion: Available evidence suggests that LncRNA CERS6-AS1 is upregulated in different cancers and has an oncogenic role. LncRNA CERS6-AS1 expression level might predict cancer prognosis, highlighting its potential application as a prognostic biomarker for cancer. Competing Interests: Conflict of Interest The authors have no conflict of interest. (Copyright © 2022 Elsevier GmbH. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cancer; Clinical significance; LncRNA CERS6-AS1; Molecular Mechanism |
| المشرفين على المادة: | 0 (RNA, Long Noncoding) 0 (MicroRNAs) EC 2.3.1.24 (CERS6 protein, human) 0 (Membrane Proteins) EC 2.3.1.24 (Sphingosine N-Acyltransferase) |
| تواريخ الأحداث: | Date Created: 20221229 Date Completed: 20230123 Latest Revision: 20230123 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.prp.2022.154245 |
| PMID: | 36580796 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1618-0631 |
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| DOI: | 10.1016/j.prp.2022.154245 |