دورية أكاديمية
أعرض في EDS

FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation.

التفاصيل البيبلوغرافية
العنوان: FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation.
المؤلفون: Leal Quirino MW; Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil. michaelwilla@hotmail.com., Albuquerque APB; Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil., de Souza MFD; Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil., Filho AFDS; Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil., Martins MR; Pernambuco Cancer Hospital, HCP, Recife, PE, Brazil., Pitta MGDR; Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil., Pereira MC; Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil., de Melo MJB; Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation Suely Galdino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil.
المصدر: Folia histochemica et cytobiologica [Folia Histochem Cytobiol] 2022; Vol. 60 (4), pp. 335-343.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Polish Histochemical and Cytochemical Society at VM Media Country of Publication: Poland NLM ID: 8502651 Publication Model: Print Cited Medium: Internet ISSN: 1897-5631 (Electronic) Linking ISSN: 02398508 NLM ISO Abbreviation: Folia Histochem Cytobiol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2011-> : Gdańsk : Polish Histochemical and Cytochemical Society at VM Media
Original Publication: Warszawa : Polish Scientific Publishers, 1984-
مواضيع طبية MeSH: Stomach Neoplasms*/diagnosis , Stomach Neoplasms*/pathology , Adenocarcinoma*/pathology , Ketone Oxidoreductases*/genetics , Ketone Oxidoreductases*/metabolism, Humans ; alpha-L-Fucosidase/metabolism ; Biomarkers ; Biomarkers, Tumor ; Carbohydrate Epimerases/genetics ; Carbohydrate Epimerases/metabolism
مستخلص: Introduction: Aberrant fucosylation is closely related to malignant transformation, cancer detection, and evaluation of treatment efficacy. The fucosylation process requires GDP-L-fucose, fucosyltransferases, and fucosidases. In gastric cancer (GC), fucosylation alterations were associated with tumor formation, metastasis inhibition, and multi-drug resistance. It is not clear whether tissue-specific transplantation antigen P35B (TSTA3) and alpha-L-fucosidase 2 (FUCA2) have any effect on the development of GC.
Materials and Methods: We used immunohistochemistry to assess the expression of TSTA3 and FUCA2 in 71 gastric adenocarcinoma samples and their relationship with clinicopathological parameters.
Results: TSTA3 expression was associated with lower histological grade I and II (P = 0.0120) and intestinal type Lauren classification (P = 0.0120). TSTA3 immunopositivity could predict Lauren's classification. Analysis of mRNA expression in GC validation cohorts corroborates the significant TSTA3 association with histological grade observed in our study. However, no associations were found between TSTA3 staining and overall survival. FUCA2 expression was markedly increased in GC tissues compared with non-tumoral tissues (P < 0.0001) and was associated with surgical staging III and IV (P = 0.0417) and advanced histological grade tumor states (P = 0.0125).
Conclusions: Alterations of FUCA2 and TSAT3 immunoexpression could lay the basis for future studies using cell glycosylation as a biomarker for the planning of therapeutic strategy in primary gastric cancer.
فهرسة مساهمة: Keywords: IHC; TSTA3; fucosidase 2; gastric cancer; glycomics
المشرفين على المادة: EC 3.2.1.51 (alpha-L-Fucosidase)
0 (Biomarkers)
0 (Biomarkers, Tumor)
EC 1.1.1.271 (TSTA3 protein, human)
EC 5.1.3.- (Carbohydrate Epimerases)
EC 1.2.- (Ketone Oxidoreductases)
EC 3.2.1.51 (FUCA2 protein, human)
تواريخ الأحداث: Date Created: 20221230 Date Completed: 20230102 Latest Revision: 20230103
رمز التحديث: 20240628
DOI: 10.5603/FHC.a2022.0031
PMID: 36583336
قاعدة البيانات: MEDLINE
الوصف
تدمد:1897-5631
DOI:10.5603/FHC.a2022.0031