دورية أكاديمية
Platelet Yield and Some Donor-Related Predictors in a Single Donor Apheresis: Report from a Nigerian Tertiary Hospital.
| العنوان: | Platelet Yield and Some Donor-Related Predictors in a Single Donor Apheresis: Report from a Nigerian Tertiary Hospital. |
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| المؤلفون: | Ugwu GC; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria., Okoye HC; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria.; Department of Haematology and Immunology, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu State, Nigeria., Nnachi OC; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria., Nwani E; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria., Nnachi OA; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria., Ezenwenyi IP; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria., Ugwu NI; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria., Okoye AE; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria. |
| المصدر: | West African journal of medicine [West Afr J Med] 2022 Dec 29; Vol. 39 (12), pp. 1280-1284. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: West African College Of Physicians And West African College Of Surgeons Country of Publication: Nigeria NLM ID: 8301891 Publication Model: Print Cited Medium: Print ISSN: 0189-160X (Print) Linking ISSN: 0189160X NLM ISO Abbreviation: West Afr J Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Lagos : West African College Of Physicians And West African College Of Surgeons Original Publication: [Yaba, Lagos, Nigeria] : West African College of Physicians and West African College of Surgeons, [1981- |
| مواضيع طبية MeSH: | Blood Platelets* , Plateletpheresis*, Humans ; Tertiary Care Centers ; Platelet Count ; Hospitals, University ; Blood Donors |
| مستخلص: | Background: Single-donor platelet transfusion is the preferred therapeutic option for patients with platelet insufficiency and its effectiveness is partly dependent on the yield. Aim: To determine the platelet yield and predictors of platelet yield in single-donor apheresis. Materials and Methods: This was a five-year review of the data on single-donor apheresis using the Haemonetics Apheresis machine MCS+ at Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi state. Platelet donor related variable of interest included the pre-donation platelet count, donor's blood group, number of apheresis cycles and yield volume. Analysis was done using Graphpad Prism version 9.1.1. Results: A total of 153 platelet apheresis were studied. The mean (SD) values for pre-donation platelet count, number of cycles, platelet yield and volume of platelet concentrate were 279 ± 47 x 109/L, 6 ± 0.3, 4.5± 0.8 X 10 11/L, and 320 ± 78 mL respectively. In this study, volume of platelet concentrate predicted 61% of platelet yield while platelet count of donor predicted 41%. Neither ABO nor Rh blood groups was a determinant of platelet yield. Conclusion: Pre-donation platelet count and volume of platelet concentrate are important predictors of platelet yield. There is need for proper platelet donor selection. Competing Interests: The Authors declare that no competing interest exists. (Copyright © 2022 by West African Journal of Medicine.) |
| فهرسة مساهمة: | Keywords: Platelet apheresis; Platelet count; Platelet volume; Platelet yield Local Abstract: [Publisher, French] La transfusion de plaquettes d’un seul donneur est l’option thérapeutique privilégiée pour les patients souffrant d’insuffisance plaquettaire et son efficacité dépend en partie du rendement. [Publisher, French] Déterminer le rendement plaquettaire et les prédicteurs du rendement plaquettaire dans l’aphérèse à donneur unique. [Publisher, French] Il s’agissait d’un examen quinquennal des données sur l’aphérèse à donneur unique utilisant l’appareil d’aphérèse Haemonetics MCS+ à l’hôpital universitaire fédéral Alex Ekwueme d’Abakaliki dans l’État d’Ebonyi. Les variables d’intérêt liées au donneur de plaquettes comprenaient la numération plaquettaire avant le don, le groupe sanguin du donneur, le nombre de cycles d’aphérèse et le volume de rendement. L’analyse a été effectuée à l’aide de Graphpad Prism version 9.1.1. [Publisher, French] Au total, 153 aphérèses plaquettaires ont été étudiées. Les valeurs moyennes (écart-type) de la numération plaquettaire avant don, du nombre de cycles, du rendement plaquettaire et du volume du concentré plaquettaire étaient respectivement de 279 ± 47 x 109/L, 6 ± 0,3, 4,5 ± 0,8 x 1011/L et 320 ± 78mL. Dans cette étude, le volume du concentré plaquettaire prédisait 61 % du rendement plaquettaire, tandis que la numération plaquettaire du donneur prédisait 41 %. Ni le groupe sanguin ABO ni le groupe sanguin Rh n’ont été des facteurs déterminants du rendement plaquettaire. [Publisher, French] La numération plaquettaire pré-don et le volume de concentré plaquettaire sont des facteurs prédictifs importants du rendement plaquettaire. Il est nécessaire de sélectionner correctement les donneurs de plaquettes. [Publisher, French] Aphérèse plaquettaire, Numération plaquettaire, Volume plaquettaire, Rendement plaquettaire. |
| تواريخ الأحداث: | Date Created: 20221230 Date Completed: 20230102 Latest Revision: 20230103 |
| رمز التحديث: | 20240628 |
| PMID: | 36583368 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0189-160X |
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