دورية أكاديمية
Total Lesion Glycolysis Obtained by FDG PET/CT in Diagnosing Solitary Pulmonary Nodules.
| العنوان: | Total Lesion Glycolysis Obtained by FDG PET/CT in Diagnosing Solitary Pulmonary Nodules. |
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| المؤلفون: | Gungor S; Department of Nuclear Medicine, Istanbul Medeniyat University, School of Medicine, Istanbul, Turkey., Gunaydin UM; Department of Oncology, The Royal Marsden Hospital, London, England., Yakar HI; Department of Chest Diseases, Tokat Gaziosmanpasa University, Tasliciftlik Yerleskesi, Tokat, Turkey., Simsek ET, Akbiyik AG; Department of Oncology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.; Department of Thoracic Surgery, Istanbul Medeniyat University, School of Medicine, Istanbul, Turkey., Keskin H; Department of Internal Medicine, Goztepe Prof. Dr. Suleyman Yalsin City Hospital, Istanbul, Turkey. |
| المصدر: | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2023 Jan; Vol. 33 (1), pp. 27-31. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: College of Physicians and Surgeons Pakistan Country of Publication: Pakistan NLM ID: 9606447 Publication Model: Print Cited Medium: Internet ISSN: 1681-7168 (Electronic) Linking ISSN: 1022386X NLM ISO Abbreviation: J Coll Physicians Surg Pak Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Karachi : College of Physicians and Surgeons Pakistan, |
| مواضيع طبية MeSH: | Positron Emission Tomography Computed Tomography*/methods , Solitary Pulmonary Nodule*/diagnostic imaging, Humans ; Fluorodeoxyglucose F18 ; Retrospective Studies ; Glycolysis ; Radiopharmaceuticals ; Prognosis |
| مستخلص: | Objective: To evaluate the diagnostic performance of total lesion glycolysis (TLG) obtained by 18F-FDG PET/ CT to differentiate malignant solitary pulmonary nodules (SPNs) from benign ones. Study Design: Observational study. Place and Duration of Study: Department of Nuclear Medicine, Istanbul Medeniyet University School of Medicine, Istanbul, Turkey, from January 2018 to April 2022. Methodology: Eighty patients, who were found to have SPNs and underwent PET/CT imaging, were enrolled in this retrospective study. Parameters of PET-CT such as metabolic, volumetric, and metabolovolumetric were assessed concerning diagnostic value. Moreover, maximum standard uptake value (SUVmax) and TLG were combined and compared to improve diagnostic accuracy. Results: The number of the detected benign and malignant SPNs was 38 and 42, respectively. Compared to the benign lesions, the malignant nodules presented significantly higher values in terms of SUVmax, TLG, and the volumes of metabolic tumour (MTV) and CT. Considering all parameters, the highest area under the curve (AUC) was occupied by TLG and SUVmax. The values for the sensitivity, specificity, and accuracy of SUVmax, TLG, and SUVmax combined with TLG were as follows respectively: 97.6%, 63.2%, and 81.2%; 85.7%, 92.1%, and 88.7%; and 85.7%, 94.7%, and 90%. Conclusion: The conventional value of SUVmax does not yield satisfactory results in order to separate the malignant nodules from the benign ones. The SUVmax value could be more valuable if it is used with TLG measurement in diagnosing SPNs. Key Words: 18F-FDG PET/CT, SUVmax, TLG, Pulmonary nodule. |
| المشرفين على المادة: | 0Z5B2CJX4D (Fluorodeoxyglucose F18) 0 (Radiopharmaceuticals) |
| تواريخ الأحداث: | Date Created: 20230104 Date Completed: 20230105 Latest Revision: 20230111 |
| رمز التحديث: | 20231215 |
| DOI: | 10.29271/jcpsp.2023.01.27 |
| PMID: | 36597231 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1681-7168 |
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| DOI: | 10.29271/jcpsp.2023.01.27 |