دورية أكاديمية
Lime and orange essential oils and d-limonene as a potential COVID-19 inhibitor: Computational, in chemico , and cytotoxicity analysis.
العنوان: | Lime and orange essential oils and d-limonene as a potential COVID-19 inhibitor: Computational, in chemico , and cytotoxicity analysis. |
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المؤلفون: | Corrêa ANR; Instituto Tecnológico em Alimentos para Saúde, Universidade do Vale do Rio dos Sinos, 93022-750, São Leopoldo, RS, Brazil., Weimer P; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, 90610-000, Porto Alegre, RS, Brazil., Rossi RC; Instituto Tecnológico em Alimentos para Saúde, Universidade do Vale do Rio dos Sinos, 93022-750, São Leopoldo, RS, Brazil., Hoffmann JF; Instituto Tecnológico em Alimentos para Saúde, Universidade do Vale do Rio dos Sinos, 93022-750, São Leopoldo, RS, Brazil., Koester LS; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, 90610-000, Porto Alegre, RS, Brazil., Suyenaga ES; Programa de Pós-Graduação em Toxicologia e Análises Toxicológicas, Universidade Feevale, 93352-000, Novo Hamburgo, RS, Brazil., Ferreira CD; Instituto Tecnológico em Alimentos para Saúde, Universidade do Vale do Rio dos Sinos, 93022-750, São Leopoldo, RS, Brazil. |
المصدر: | Food bioscience [Food Biosci] 2023 Feb; Vol. 51, pp. 102348. Date of Electronic Publication: 2022 Dec 30. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101623512 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2212-4292 (Print) Linking ISSN: 22124292 NLM ISO Abbreviation: Food Biosci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, [2013]- |
مستخلص: | The COVID-19 pandemic has substantially impacted the world health systems, causing public health concerns, and the search for new compounds with antiviral activity is of extreme interest. Natural molecules with bioactive potential are a trend, with essential oils (Eos) being the focus of recent studies. Thus, this study evaluates in chemico the d-limonene inhibitory activities in the viral genome of SARS-CoV-2 and analyzes the cytotoxic potential and safety profile of d-limonene and lime and orange EOs with a high content of d-limonene. The EOs were extracted and characterized, and the in chemico computational analysis for the determination as a potential anti-SARS-CoV-2 was performed with d-limonene, the major compound in EOs. The cytotoxicity analysis of EOs and d-limonene was carried out with MRC-5 and HaCaT, and the preliminary safety profile was also evaluated by the HET-CAM assay. d-limonene was suggested as a promising compound for anti-SARS-CoV-2 research, since the molecule does not provide mutagenic and cytotoxic fragments, and does not have irritating potential when diluted, in addition to having favorable pharmacokinetic characteristics, through in chemico analysis. Collectively, the results reveal the antiviral potential of lime and orange EOs, as well as their major compound. In this sense, further studies should be conducted to understand the antiviral mechanisms. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 Elsevier Ltd. All rights reserved.) |
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فهرسة مساهمة: | Keywords: COVID-19; Essential oils; anti-Sars-CoV-2; d-limonene |
تواريخ الأحداث: | Date Created: 20230104 Latest Revision: 20230124 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9801698 |
DOI: | 10.1016/j.fbio.2022.102348 |
PMID: | 36597499 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2212-4292 |
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DOI: | 10.1016/j.fbio.2022.102348 |