دورية أكاديمية
أعرض في EDS

Lime and orange essential oils and d-limonene as a potential COVID-19 inhibitor: Computational, in chemico , and cytotoxicity analysis.

التفاصيل البيبلوغرافية
العنوان: Lime and orange essential oils and d-limonene as a potential COVID-19 inhibitor: Computational, in chemico , and cytotoxicity analysis.
المؤلفون: Corrêa ANR; Instituto Tecnológico em Alimentos para Saúde, Universidade do Vale do Rio dos Sinos, 93022-750, São Leopoldo, RS, Brazil., Weimer P; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, 90610-000, Porto Alegre, RS, Brazil., Rossi RC; Instituto Tecnológico em Alimentos para Saúde, Universidade do Vale do Rio dos Sinos, 93022-750, São Leopoldo, RS, Brazil., Hoffmann JF; Instituto Tecnológico em Alimentos para Saúde, Universidade do Vale do Rio dos Sinos, 93022-750, São Leopoldo, RS, Brazil., Koester LS; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, 90610-000, Porto Alegre, RS, Brazil., Suyenaga ES; Programa de Pós-Graduação em Toxicologia e Análises Toxicológicas, Universidade Feevale, 93352-000, Novo Hamburgo, RS, Brazil., Ferreira CD; Instituto Tecnológico em Alimentos para Saúde, Universidade do Vale do Rio dos Sinos, 93022-750, São Leopoldo, RS, Brazil.
المصدر: Food bioscience [Food Biosci] 2023 Feb; Vol. 51, pp. 102348. Date of Electronic Publication: 2022 Dec 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101623512 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2212-4292 (Print) Linking ISSN: 22124292 NLM ISO Abbreviation: Food Biosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, [2013]-
مستخلص: The COVID-19 pandemic has substantially impacted the world health systems, causing public health concerns, and the search for new compounds with antiviral activity is of extreme interest. Natural molecules with bioactive potential are a trend, with essential oils (Eos) being the focus of recent studies. Thus, this study evaluates in chemico the d-limonene inhibitory activities in the viral genome of SARS-CoV-2 and analyzes the cytotoxic potential and safety profile of d-limonene and lime and orange EOs with a high content of d-limonene. The EOs were extracted and characterized, and the in chemico computational analysis for the determination as a potential anti-SARS-CoV-2 was performed with d-limonene, the major compound in EOs. The cytotoxicity analysis of EOs and d-limonene was carried out with MRC-5 and HaCaT, and the preliminary safety profile was also evaluated by the HET-CAM assay. d-limonene was suggested as a promising compound for anti-SARS-CoV-2 research, since the molecule does not provide mutagenic and cytotoxic fragments, and does not have irritating potential when diluted, in addition to having favorable pharmacokinetic characteristics, through in chemico analysis. Collectively, the results reveal the antiviral potential of lime and orange EOs, as well as their major compound. In this sense, further studies should be conducted to understand the antiviral mechanisms.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 Elsevier Ltd. All rights reserved.)
References: Res Pharm Sci. 2019 Oct 04;14(5):448-458. (PMID: 31798662)
Molecules. 2020 Apr 19;25(8):. (PMID: 32325864)
Biomed Pharmacother. 2022 Jul;151:113151. (PMID: 35598364)
Microb Pathog. 2022 Apr;165:105497. (PMID: 35337962)
Hum Exp Toxicol. 2012 Aug;31(8):798-811. (PMID: 22318307)
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. (PMID: 6606682)
J Ethnopharmacol. 2018 Feb 15;212:86-94. (PMID: 29055721)
Int J Mol Sci. 2020 May 12;21(10):. (PMID: 32408699)
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26. (PMID: 11259830)
Nat Rev Microbiol. 2021 Mar;19(3):141-154. (PMID: 33024307)
Clin Infect Dis. 2020 Dec 3;71(9):2459-2468. (PMID: 32358954)
Braz J Microbiol. 2010 Oct;41(4):1070-8. (PMID: 24031588)
Food Environ Virol. 2019 Mar;11(1):90-95. (PMID: 30684236)
Microbiologyopen. 2017 Aug;6(4):. (PMID: 28296357)
ChemistrySelect. 2020 Jun 8;5(21):6312-6320. (PMID: 32572383)
Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):38-44. (PMID: 19796276)
Front Cell Infect Microbiol. 2020 Nov 25;10:587269. (PMID: 33324574)
J Agric Food Chem. 2019 Dec 18;67(50):13817-13828. (PMID: 30905156)
Molecules. 2022 Feb 01;27(3):. (PMID: 35164253)
J Pharm Pharmacol. 2017 Nov;69(11):1606-1614. (PMID: 28815601)
Biosci Rep. 2018 Nov 13;38(6):. (PMID: 30287506)
Food Chem Toxicol. 1985 Feb;23(2):287-91. (PMID: 4040077)
J Virol. 2020 Jul 16;94(15):. (PMID: 32461309)
N Engl J Med. 2021 Jul 22;385(4):330-341. (PMID: 34289276)
Arch Toxicol. 2021 Feb;95(2):673-691. (PMID: 33159585)
J Sci Food Agric. 2019 Feb;99(3):1020-1028. (PMID: 30009387)
ACS Omega. 2020 Mar 31;5(14):8312-8320. (PMID: 32363255)
Drug Dev Ind Pharm. 2020 Nov;46(11):1787-1799. (PMID: 32896171)
Int J Mol Sci. 2020 Feb 20;21(4):. (PMID: 32093358)
3 Biotech. 2018 Sep;8(9):395. (PMID: 30221108)
فهرسة مساهمة: Keywords: COVID-19; Essential oils; anti-Sars-CoV-2; d-limonene
تواريخ الأحداث: Date Created: 20230104 Latest Revision: 20230124
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9801698
DOI: 10.1016/j.fbio.2022.102348
PMID: 36597499
قاعدة البيانات: MEDLINE
الوصف
تدمد:2212-4292
DOI:10.1016/j.fbio.2022.102348