دورية أكاديمية
Pneumonia hospitalizations and mortality in children 3 - 24-month-old in Nigeria from 2013 to 2020: Impact of pneumococcal conjugate vaccine ten valent (PHiD-CV-10).
| العنوان: | Pneumonia hospitalizations and mortality in children 3 - 24-month-old in Nigeria from 2013 to 2020: Impact of pneumococcal conjugate vaccine ten valent (PHiD-CV-10). |
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| المؤلفون: | Iliya J; Department of Pediatrics, Gombe State University, Gombe, Nigeria., Shatima DR; Department of Pediatrics, National Hospital Abuja, Abuja, Nigeria., Tagbo BN; Department of Pediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria., Ayede AI; Department of Pediatrics, University College Hospital, Ibadan, Nigeria.; Department of Pediatrics, University of Ibadan, Ibadan, Nigeria., Fagbohun AO; Department of Pediatrics, University College Hospital, Ibadan, Nigeria., Rasaq A; Department of Pediatrics, Gombe State University, Gombe, Nigeria., Nalban S; Department of Pediatrics, Gombe State University, Gombe, Nigeria., Elon IW; Department of Pediatrics, Gombe State University, Gombe, Nigeria., Mohammed-Nafiu R; Department of Pediatrics, National Hospital Abuja, Abuja, Nigeria., Ahmed P; Department of Pediatrics, National Hospital Abuja, Abuja, Nigeria., Oyewole OB; Department of Pediatrics, University College Hospital, Ibadan, Nigeria., Bakare AA; Department of Pediatrics, University College Hospital, Ibadan, Nigeria., Yusuf BO; Department of Epidemiology, Medical Statistics and Environmental Health, University of Ibadan, Ibadan, Nigeria., Akinrinoye OO; Department of Pediatrics, University College Hospital, Ibadan, Nigeria., Ogala WN; Department of Pediatrics, Ahmadu Bello University, Zaria, Nigeria., Falade AG; Department of Pediatrics, University College Hospital, Ibadan, Nigeria.; Department of Pediatrics, University of Ibadan, Ibadan, Nigeria. |
| المصدر: | Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2023 Dec 31; Vol. 19 (1), pp. 2162289. Date of Electronic Publication: 2023 Jan 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, Tex. : Landes Bioscience |
| مواضيع طبية MeSH: | Pneumonia*/epidemiology , Pneumococcal Infections*/prevention & control , Pneumonia, Pneumococcal*/epidemiology , Pneumonia, Pneumococcal*/prevention & control, Humans ; Child ; Infant ; Child, Preschool ; Vaccines, Conjugate/therapeutic use ; Retrospective Studies ; Nigeria/epidemiology ; Pneumococcal Vaccines ; Hospitalization ; Hospitals, University |
| مستخلص: | Pneumococcal conjugate vaccine ten valent (PCV 10) was introduced into Nigeria in three phases. Phase 3 introduction started in August 2016. However, its impact on pneumonia admissions and mortality among vaccinated Nigerian children has not been determined. Data in the period before PCV-10 introduction (3 August 2013-2 August 2016), and after (3 August 2017-2 August 2020) were retrospectively extracted from the medical charts of eligible patients aged 3-24 months with hospitalized radiological pneumonia at the University College Hospital (UCH), Ibadan; National Hospital (NH), Abuja; and Federal Teaching Hospital (FTH), Gombe, allowing for an intervening period of 1 year. Proportions of the patients with hospitalized pneumonia and case fatality rates were determined during both periods. The results were compared using z-test, multiple logistic regression analysis and p < .05 was considered significant. Adjusted pneumonia hospitalization rates between the two periods increased at the NH Abuja (10.7% vs 14.6%); decreased at the UCH, Ibadan (8.7% vs 6.9%); and decreased at the FTH, Gombe (28.5% vs 18.9%). Case fatality rates decreased across all the sites during the post-PCV introduction period: NH Abuja, from 6.6% to 4.4% ( p = .106); FTH, Gombe, 11.7% to 7.7% ( p = .477); and UCH, Ibadan, 2.0% to 0% ( p = .045); but only significant at Ibadan. Overall, proportion of hospitalized pneumonia cases decreased after 3 years of PCV 10 introduction into the National Immunization Programme in Nigeria. The case fatality rate during post-PCV 10 introduction decreased at all the three sites, but this difference was significant at the UCH, Ibadan. |
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| فهرسة مساهمة: | Keywords: Nigeria; PCV-10; childhood pneumonia; hospitalizations; mortality Local Abstract: [plain-language-summary] Pneumonia is the commonest killer of Nigerian children aged less than 5 years. Pneumonia vaccine (PCV 10) was introduced into Nigeria Vaccination Program between 2014 and 2016, but up till now the value has not been confirmed. We conducted a retrospective study in which data before and after PCV 10 introduction were compared. The study sites were the University College Hospital (UCH), Ibadan; National Hospital (NH), Abuja; and Federal Teaching Hospital (FTH), Gombe. The data were extracted from the medical charts of eligible patients aged 3–24 months who were admitted for severe pneumonia with evidences on lung radiographs. We found that the proportion of hospitalized pneumonia cases decreased after 3 years of PCV 10 introduction into the National Immunization Program in Nigeria. The death rate during post-PCV 10 introduction decreased at all the three sites, but was only significantly decreased at the UCH, Ibadan. |
| المشرفين على المادة: | 0 (Vaccines, Conjugate) 0 (Pneumococcal Vaccines) |
| SCR Disease Name: | Histiocytosis with joint contractures and sensorineural deafness |
| تواريخ الأحداث: | Date Created: 20230104 Date Completed: 20230222 Latest Revision: 20230304 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9980440 |
| DOI: | 10.1080/21645515.2022.2162289 |
| PMID: | 36597576 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2164-554X |
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| DOI: | 10.1080/21645515.2022.2162289 |