دورية أكاديمية
α-Cyclodextrin-based poly(pseudo)rotaxane for antifungal drug delivery to the vaginal mucosa.
| العنوان: | α-Cyclodextrin-based poly(pseudo)rotaxane for antifungal drug delivery to the vaginal mucosa. |
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| المؤلفون: | Costa RHF; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), 70910-900 Brasília, DF, Brazil., Krawczyk-Santos AP; Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Federal University of Goiás (UFG), 74605-170 Goiânia, GO, Brazil., Martins Andrade JF; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), 70910-900 Brasília, DF, Brazil., Barbalho GN; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), 70910-900 Brasília, DF, Brazil., Almeida RM; Clinical Microbiology and Immunology Laboratory, Department of Pharmacy, University of Brasilia (UnB), 70910-900 Brasilia, DF, Brazil., Nóbrega YKM; Clinical Microbiology and Immunology Laboratory, Department of Pharmacy, University of Brasilia (UnB), 70910-900 Brasilia, DF, Brazil., Cunha-Filho M; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), 70910-900 Brasília, DF, Brazil., Gelfuso GM; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), 70910-900 Brasília, DF, Brazil., Taveira SF; Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Federal University of Goiás (UFG), 74605-170 Goiânia, GO, Brazil., Gratieri T; Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), 70910-900 Brasília, DF, Brazil. Electronic address: tgratieri@unb.br. |
| المصدر: | Carbohydrate polymers [Carbohydr Polym] 2023 Feb 15; Vol. 302, pp. 120420. Date of Electronic Publication: 2022 Nov 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1992-> : Barking : Elsevier Applied Science Publishers Original Publication: London [Eng.] : Applied Science Publishers, c1981- |
| مواضيع طبية MeSH: | Rotaxanes*/chemistry , alpha-Cyclodextrins*, Female ; Animals ; Swine ; Antifungal Agents/chemistry ; Vagina ; Candida albicans ; Mucous Membrane |
| مستخلص: | This work aimed to evaluate poly(pseudo)rotaxanes (PPRs) potential for vaginal antifungal delivery. For this, PPRs containing terbinafine (TB) 2 % were obtained using two small surfactants, Kolliphor® RH40 and Gelucire® 48/16, and different α-cyclodextrin (α-CD) concentrations (5 and 10 %). PPRs were characterized by their physicochemical characteristics, irritation, and mucoadhesion capabilities. Formulations' performance was assessed in a vertical penetration model, which uses ex vivo entire porcine vagina. Conventional penetration experiments with excised vaginal tissue were performed as a control. Results showed all formulations were non-irritant according to the HET-CAM test. Furthermore, PPRs with 10 % αCD showed superior mucoadhesion (p < 0.05). Conventional horizontal penetration studies could not differentiate formulations (p > 0.05). However, PPRs with 10 % αCD presented a better performance in vertical ex vivo studies, achieving higher drug penetration into the vaginal mucosa (p < 0.05), which is probably related to the formulation's prolonged residence time. In addition, the antifungal activity of the formulations was maintained against Candida albicans and C. glabrata cultures. More importantly, the formulation's viscosity and drug delivery control had no negative impact on the antifungal activity. In conclusion, the best performance in a more realistic model evidenced the remarkable potential of PPRs for vaginal drug delivery. Competing Interests: Declaration of competing interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alpha-cyclodextrin; Candidiasis; Mixed micelles; Poly(pseudo)rotaxanes; Terbinafine; Vaginal drug delivery |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Rotaxanes) 0 (alpha-Cyclodextrins) |
| تواريخ الأحداث: | Date Created: 20230105 Date Completed: 20230109 Latest Revision: 20230111 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.carbpol.2022.120420 |
| PMID: | 36604082 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1344 |
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| DOI: | 10.1016/j.carbpol.2022.120420 |