دورية أكاديمية
أعرض في EDS

Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype-specific signatures, clinical correlates, and practical relevance.

التفاصيل البيبلوغرافية
العنوان: Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype-specific signatures, clinical correlates, and practical relevance.
المؤلفون: McKenna MC; Computational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Department of Neurology, St James's Hospital, Dublin, Ireland., Lope J; Computational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Bede P; Computational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Department of Neurology, St James's Hospital, Dublin, Ireland., Tan EL; Computational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
المصدر: Brain and behavior [Brain Behav] 2023 Feb; Vol. 13 (2), pp. e2881. Date of Electronic Publication: 2023 Jan 07.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hoboken, NJ : John Wiley & Sons
مواضيع طبية MeSH: Frontotemporal Dementia*/diagnostic imaging , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/pathology , Thalamic Diseases*/pathology, Humans ; Magnetic Resonance Imaging ; Thalamus/pathology ; Phenotype
مستخلص: Background: Frontotemporal dementia (FTD) phenotypes are classically associated with distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of cognitive and behavioral manifestations in FTD arises from multisynaptic network dysfunction. The thalamus is a key hub of several corticobasal and corticocortical circuits. The main circuits relayed via the thalamic nuclei include the dorsolateral prefrontal circuit, the anterior cingulate circuit, and the orbitofrontal circuit.
Methods: In this paper, we have reviewed evidence for thalamic pathology in FTD based on radiological and postmortem studies. Original research papers were systematically reviewed for preferential involvement of specific thalamic regions, for phenotype-associated thalamic disease burden patterns, characteristic longitudinal changes, and genotype-associated thalamic signatures. Moreover, evidence for presymptomatic thalamic pathology was also reviewed. Identified papers were systematically scrutinized for imaging methods, cohort sizes, clinical profiles, clinicoradiological associations, and main anatomical findings. The findings of individual research papers were amalgamated for consensus observations and their study designs further evaluated for stereotyped shortcomings. Based on the limitations of existing studies and conflicting reports in low-incidence FTD variants, we sought to outline future research directions and pressing research priorities.
Results: FTD is associated with focal thalamic degeneration. Phenotype-specific thalamic traits mirror established cortical vulnerability patterns. Thalamic nuclei mediating behavioral and language functions are preferentially involved. Given the compelling evidence for considerable thalamic disease burden early in the course of most FTD subtypes, we also reflect on the practical relevance, diagnostic role, prognostic significance, and monitoring potential of thalamic metrics in FTD.
Conclusions: Cardinal manifestations of FTD phenotypes are likely to stem from thalamocortical circuitry dysfunction and are not exclusively driven by focal cortical changes.
(© 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
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معلومات مُعتمدة: Irish Institute of Clinical Neuroscience (IICN); Spastic Paraplegia Foundation (SPF); EU Joint Programme-Neurodegenerative Disease Research (JPND); Andrew Lydon scholarship; Iris O'Brien Foundation; HRB EIA-2017-019 Ireland HRBI_ Health Research Board; JPND-Cofund-2-2019-1 Ireland HRBI_ Health Research Board
فهرسة مساهمة: Keywords: MRI; frontotemporal dementia; neuroimaging; thalamus
تواريخ الأحداث: Date Created: 20230107 Date Completed: 20230216 Latest Revision: 20230302
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9927864
DOI: 10.1002/brb3.2881
PMID: 36609810
قاعدة البيانات: MEDLINE
الوصف
تدمد:2162-3279
DOI:10.1002/brb3.2881