دورية أكاديمية
أعرض في EDS

Collagen-Specific Molecular Magnetic Resonance Imaging of Prostate Cancer.

التفاصيل البيبلوغرافية
العنوان: Collagen-Specific Molecular Magnetic Resonance Imaging of Prostate Cancer.
المؤلفون: Kader A; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.; Department of Biology, Chemistry and Pharmacy, Institute of Biology, Freie Universität Berlin, Königin-Luise-Str. 1-3, 14195 Berlin, Germany.; Department of Diagnostic and Interventional Radiology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany., Kaufmann JO; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.; Department of Diagnostic and Interventional Radiology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.; Bundesanstalt für Materialforschung und -prüfung (BAM), Division 1.5 Protein Analysis, Richard-Willstätter-Str. 11, 12489 Berlin, Germany.; Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany., Mangarova DB; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.; Department of Diagnostic and Interventional Radiology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany., Moeckel J; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany., Adams LC; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany., Brangsch J; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.; Department of Diagnostic and Interventional Radiology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany., Heyl JL; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany., Zhao J; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany., Verlemann C; Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 48, 48149 Münster, Germany., Karst U; Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 48, 48149 Münster, Germany., Collettini F; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.; BIH Charité Clinician Scientist Program, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10178 Berlin, Germany., Auer TA; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.; BIH Charité Clinician Scientist Program, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10178 Berlin, Germany., Hamm B; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany., Makowski MR; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.; Department of Diagnostic and Interventional Radiology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.; School of Biomedical Engineering and Imaging Sciences, United Kingdom, King's College London, St Thomas' Hospital Westminster Bridge Road, London SE1 7EH, UK.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 31; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Prostatic Neoplasms*/metabolism, Male ; Humans ; Mice ; Animals ; Collagen/metabolism ; Magnetic Resonance Imaging/methods ; Extracellular Matrix/metabolism
مستخلص: Constant interactions between tumor cells and the extracellular matrix (ECM) influence the progression of prostate cancer (PCa). One of the key components of the ECM are collagen fibers, since they are responsible for the tissue stiffness, growth, adhesion, proliferation, migration, invasion/metastasis, cell signaling, and immune recruitment of tumor cells. To explore this molecular marker in the content of PCa, we investigated two different tumor volumes (500 mm3 and 1000 mm3) of a xenograft mouse model of PCa with molecular magnetic resonance imaging (MRI) using a collagen-specific probe. For in vivo MRI evaluation, T1-weighted sequences before and after probe administration were analyzed. No significant signal difference between the two tumor volumes could be found. However, we detected a significant difference between the signal intensity of the peripheral tumor area and the central area of the tumor, at both 500 mm3 (p < 0.01, n = 16) and at 1000 mm3 (p < 0.01, n = 16). The results of our histologic analyses confirmed the in vivo studies: There was no significant difference in the amount of collagen between the two tumor volumes (p > 0.05), but within the tumor, higher collagen expression was observed in the peripheral area compared with the central area of the tumor. Laser ablation with inductively coupled plasma mass spectrometry further confirmed these results. The 1000 mm3 tumors contained 2.8 ± 1.0% collagen and the 500 mm3 tumors contained 3.2 ± 1.2% (n = 16). There was a strong correlation between the in vivo MRI data and the ex vivo histological data (y = −0.068x + 1.1; R2 = 0.74) (n = 16). The results of elemental analysis by inductively coupled plasma mass spectrometry supported the MRI data (y = 3.82x + 0.56; R2 = 0.79; n = 7). MRI with the collagen-specific probe in PCa enables differentiation between different tumor areas. This may help to differentiate tumor from healthy tissue, potentially identifying tumor areas with a specific tumor biology.
References: Cell. 2009 Nov 25;139(5):891-906. (PMID: 19931152)
Cancers (Basel). 2014 Aug 13;6(3):1670-90. (PMID: 25125485)
Cancers (Basel). 2022 Jun 11;14(12):. (PMID: 35740556)
Radiology. 2008 Jun;247(3):788-96. (PMID: 18403626)
PLoS One. 2022 Mar 1;17(3):e0264571. (PMID: 35231060)
Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. (PMID: 32775149)
Cell Rep. 2017 Dec 26;21(13):3662-3671. (PMID: 29281816)
Nat Nanotechnol. 2016 Nov;11(11):986-994. (PMID: 27668795)
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11208-11213. (PMID: 27663743)
World J Stem Cells. 2015 Mar 26;7(2):495-501. (PMID: 25815134)
Cancers (Basel). 2021 Jan 27;13(3):. (PMID: 33513979)
J Nucl Med. 2012 Apr;53(4):538-45. (PMID: 22343504)
Rev Urol. 2002 Summer;4(3):157-8. (PMID: 16985672)
Front Oncol. 2021 Jul 14;11:668349. (PMID: 34336660)
Clin Exp Metastasis. 2016 Feb;33(2):151-65. (PMID: 26567111)
Anal Chem. 2021 Nov 30;93(47):15720-15727. (PMID: 34784194)
Integr Biol (Camb). 2015 Oct;7(10):1120-34. (PMID: 25959051)
Carcinogenesis. 2008 May;29(5):964-70. (PMID: 18296681)
Adv Cancer Res. 2022;154:15-45. (PMID: 35459468)
Nat Commun. 2015 Apr 30;6:6993. (PMID: 25925867)
Int J Mol Sci. 2019 Jan 11;20(2):. (PMID: 30641920)
Front Oncol. 2018 May 04;8:145. (PMID: 29780748)
Cancers (Basel). 2022 Jun 13;14(12):. (PMID: 35740575)
J Natl Cancer Inst. 2011 Mar 2;103(5):407-24. (PMID: 21282564)
J Biophotonics. 2017 Jun;10(6-7):911-918. (PMID: 27545683)
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18273-7. (PMID: 19011090)
Cancer Lett. 2015 Feb 1;357(1):121-128. (PMID: 25444932)
J Transl Med. 2019 Sep 14;17(1):309. (PMID: 31521169)
J Exp Clin Cancer Res. 2019 Mar 6;38(1):115. (PMID: 30841909)
Exp Cell Res. 2010 May 1;316(8):1324-31. (PMID: 20211171)
Angew Chem Int Ed Engl. 2007;46(43):8171-3. (PMID: 17893943)
Front Appl Math Stat. 2021 Jun;7:. (PMID: 34322539)
Br J Radiol. 2019 May;92(1097):20180970. (PMID: 30875242)
Cold Spring Harb Perspect Biol. 2011 Jan 01;3(1):a004978. (PMID: 21421911)
Biology (Basel). 2021 Nov 22;10(11):. (PMID: 34827210)
Int J Mol Sci. 2016 Dec 29;18(1):. (PMID: 28036074)
Clin Cancer Res. 2002 Sep;8(9):2912-23. (PMID: 12231536)
J Tissue Eng. 2014 Dec 20;5:2041731414557112. (PMID: 25610589)
J Hepatol. 2013 Nov;59(5):992-8. (PMID: 23838178)
Front Immunol. 2020 Jun 26;11:1142. (PMID: 32676074)
Sci Rep. 2020 Sep 16;10(1):15206. (PMID: 32939002)
J Cell Biol. 2013 Sep 16;202(6):951-66. (PMID: 24019537)
Acta Histochem. 2015 Jan;117(1):4-13. (PMID: 25466989)
Lab Invest. 2018 Mar;98(3):380-390. (PMID: 29251735)
Sci Rep. 2017 Aug 14;7(1):8114. (PMID: 28808290)
NPJ Precis Oncol. 2022 May 4;6(1):31. (PMID: 35508696)
Ultrason Imaging. 1998 Oct;20(4):260-74. (PMID: 10197347)
Biochim Biophys Acta. 1975 Apr 29;386(2):444-50. (PMID: 1169969)
Phys Rev E. 2019 Jun;99(6-1):062414. (PMID: 31330715)
Radiology. 2010 Mar;254(3):925-33. (PMID: 20177103)
Biochemistry. 2010 Feb 23;49(7):1364-76. (PMID: 20102226)
Biochim Biophys Acta. 2013 Jul;1832(7):866-75. (PMID: 23220448)
معلومات مُعتمدة: SFB1340-B01 Deutsche Forschungsgemeinschaft
فهرسة مساهمة: Keywords: collagen; magnetic resonance imaging; molecular imaging; prostate cancer
المشرفين على المادة: 9007-34-5 (Collagen)
تواريخ الأحداث: Date Created: 20230108 Date Completed: 20230110 Latest Revision: 20230308
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9821004
DOI: 10.3390/ijms24010711
PMID: 36614152
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24010711