دورية أكاديمية
أعرض في EDS

Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis.

التفاصيل البيبلوغرافية
العنوان: Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis.
المؤلفون: Alves A; CarMeN laboratory, UMR INSERM U1060/INRAE U1397, Université Claude Bernard Lyon 1, Université de Lyon, 69310 Pierre-Bénite, France., Lamarche F; Laboratory of Fundamental and Applied Bioenergetics, INSERM U1055, Université Grenoble Alpes, 38400 Saint Martin d'Hères, France., Lefebvre R; CarMeN laboratory, UMR INSERM U1060/INRAE U1397, Université Claude Bernard Lyon 1, Université de Lyon, 69310 Pierre-Bénite, France., Drevet Mulard E; ICBMS CNRS U5246, Université Claude Bernard Lyon 1, Université de Lyon, 69622 Villeurbanne, France., Bassot A; Erika Cosset Team, Cancer Research Centre of Lyon, UMR INSERM U1052/CNRS 5286, 69008 Lyon, France., Chanon S; CarMeN laboratory, UMR INSERM U1060/INRAE U1397, Université Claude Bernard Lyon 1, Université de Lyon, 69310 Pierre-Bénite, France., Loizon E; CarMeN laboratory, UMR INSERM U1060/INRAE U1397, Université Claude Bernard Lyon 1, Université de Lyon, 69310 Pierre-Bénite, France., Pinteur C; CarMeN laboratory, UMR INSERM U1060/INRAE U1397, Université Claude Bernard Lyon 1, Université de Lyon, 69310 Pierre-Bénite, France., Bloise AMNLG; Department of Physical Education and Sport Sciences, Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Universidade Federal de Pernambuco, UFPE, 55604-000 Vitória de Santo Antão, PE, Brazil., Godet M; CarMeN laboratory, UMR INSERM U1060/INRAE U1397, Université Claude Bernard Lyon 1, Université de Lyon, 69310 Pierre-Bénite, France., Rautureau GJP; ICBMS CNRS U5246, Université Claude Bernard Lyon 1, Université de Lyon, 69622 Villeurbanne, France.; Centre de Résonance Magnétique Nucléaire à Très Hauts Champs, UMR CNRS U5082/ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, 69100 Villeurbanne, France., Panthu B; CarMeN laboratory, UMR INSERM U1060/INRAE U1397, Université Claude Bernard Lyon 1, Université de Lyon, 69310 Pierre-Bénite, France., Morio B; CarMeN laboratory, UMR INSERM U1060/INRAE U1397, Université Claude Bernard Lyon 1, Université de Lyon, 69310 Pierre-Bénite, France.
المصدر: Nutrients [Nutrients] 2022 Dec 24; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Glucose Intolerance*/metabolism , Insulin Resistance*/physiology, Male ; Rats ; Mice ; Animals ; Gluconeogenesis ; Glycine/pharmacology ; Liver/metabolism ; Obesity/drug therapy ; Obesity/metabolism ; Insulin ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Mice, Inbred C57BL
مستخلص: Interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in the liver in obesity, which contributes to disruption of the insulin signaling pathway. In addition, the plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance. Certain nutrients have been shown to regulate MAMs; therefore, we tested whether glycine supplementation could reduce insulin resistance in the liver by promoting MAM integrity. Glycine (5 mM) supported MAM integrity and insulin response in primary rat hepatocytes cultured under control and lipotoxic (palmitate 500 µM) conditions for 18 h. In contrast, in C57 BL/6 JOlaHsd mice (male, 6 weeks old) fed a high-fat, high-sucrose diet (HFHS) for 16 weeks, glycine supplementation (300 mg/kg) in drinking water during the last 6 weeks (HFHS-Gly) did not reverse the deleterious impact of HFHS-feeding on liver MAM integrity. In addition, glycine supplementation worsened fasting glycemia and glycemic response to intraperitoneal pyruvate injection compared to HFHS. The adverse impact of glycine supplementation on hepatic gluconeogenesis was further supported by the higher oxaloacetate/acetyl-CoA ratio in the liver in HFHS-Gly compared to HFHS. Although glycine improves MAM integrity and insulin signaling in the hepatocyte in vitro, no beneficial effect was found on the overall metabolic profile of HFHS-Gly-fed mice.
References: J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S148-50. (PMID: 26598833)
Cell Rep. 2020 Nov 10;33(6):108375. (PMID: 33176135)
Diabetes Res Clin Pract. 2017 Oct;132:45-58. (PMID: 28783532)
J Basic Clin Pharm. 2016 Mar;7(2):27-31. (PMID: 27057123)
PLoS One. 2010 May 28;5(5):e10883. (PMID: 20526369)
J Hepatol. 2022 Sep;77(3):710-722. (PMID: 35358616)
Oncotarget. 2016 Dec 6;7(49):80223-80237. (PMID: 27784003)
Diabetes Care. 2016 May;39(5):833-46. (PMID: 27208380)
Sci Rep. 2021 Apr 22;11(1):8712. (PMID: 33888788)
Cell Metab. 2017 Jan 10;25(1):27-42. (PMID: 27641100)
Mol Cell Endocrinol. 2018 Feb 5;461:205-214. (PMID: 28923347)
J Mol Cell Biol. 2016 Apr;8(2):129-43. (PMID: 26892023)
Cells. 2019 Oct 25;8(11):. (PMID: 31731523)
C R Seances Soc Biol Fil. 1966;160(6):1148-50. (PMID: 4225953)
Nutr Metab (Lond). 2016 Jan 19;13:5. (PMID: 26788116)
Diabetes. 2014 Oct;63(10):3279-94. (PMID: 24947355)
Nutrients. 2019 Jun 16;11(6):. (PMID: 31208147)
J Cell Biol. 1969 Dec;43(3):506-20. (PMID: 4900611)
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Dec;1866(12):159030. (PMID: 34419589)
Diabetes Care. 2009 Nov;32 Suppl 2:S157-63. (PMID: 19875544)
Diabetes. 2013 Feb;62(2):639-48. (PMID: 23043162)
Mol Syst Biol. 2012;8:615. (PMID: 23010998)
Aliment Pharmacol Ther. 2017 Nov;46(10):974-980. (PMID: 28914448)
Diabetologia. 2015 Sep;58(9):2133-43. (PMID: 26058503)
J Clin Endocrinol Metab. 2014 Jan;99(1):169-77. (PMID: 24081740)
Diabetologia. 2016 Mar;59(3):614-23. (PMID: 26660890)
Anal Chim Acta. 2016 Aug 31;934:194-202. (PMID: 27506360)
Exp Cell Res. 2017 Oct 1;359(1):86-93. (PMID: 28827061)
J Clin Endocrinol Metab. 2015 Mar;100(3):E463-8. (PMID: 25423564)
Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):865-876. (PMID: 28064001)
Nat Protoc. 2006;1(2):581-5. (PMID: 17406285)
Eur J Biochem. 1982 Feb;122(1):87-93. (PMID: 7060572)
معلومات مُعتمدة: prix de recherche 2020 Société Francophone du Diabète
فهرسة مساهمة: Keywords: amino acid metabolism; dietary supplement; insulin resistance; mitochondria; obesity-related metabolic disorders
المشرفين على المادة: TE7660XO1C (Glycine)
0 (Insulin)
تواريخ الأحداث: Date Created: 20230108 Date Completed: 20230110 Latest Revision: 20230111
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9823780
DOI: 10.3390/nu15010096
PMID: 36615754
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu15010096