دورية أكاديمية
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The Cytotoxic Effectiveness of Thiourea-Reduced Graphene Oxide on Human Lung Cancer Cells and Fungi.

التفاصيل البيبلوغرافية
العنوان: The Cytotoxic Effectiveness of Thiourea-Reduced Graphene Oxide on Human Lung Cancer Cells and Fungi.
المؤلفون: Vimalanathan B; Crystal Growth Centre, Anna University, Chennai 600025, Tamil Nadu, India., Vijaya JJ; Catalysis and Nanomaterials Research Laboratory, Department of Chemistry, Loyola College, Chennai 600034, Tamil Nadu, India., Mary BCJ; Catalysis and Nanomaterials Research Laboratory, Department of Chemistry, Loyola College, Chennai 600034, Tamil Nadu, India., Mary RN; Crystal Growth Centre, Anna University, Chennai 600025, Tamil Nadu, India., Km M; Catalysis and Nanomaterials Research Laboratory, Department of Chemistry, Loyola College, Chennai 600034, Tamil Nadu, India., Jayavel R; Crystal Growth Centre, Anna University, Chennai 600025, Tamil Nadu, India., Abumousa RA; Department of Mathematics and Sciences, College of Humanities and Sciences, Prince Sultan University, Riyadh 11586, Saudi Arabia., Bououdina M; Department of Mathematics and Sciences, College of Humanities and Sciences, Prince Sultan University, Riyadh 11586, Saudi Arabia.
المصدر: Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2022 Dec 28; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101610216 Publication Model: Electronic Cited Medium: Print ISSN: 2079-4991 (Print) Linking ISSN: 20794991 NLM ISO Abbreviation: Nanomaterials (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2011]-
مستخلص: This study demonstrated the effective reduction of graphene oxide (GO) by employing thiourea as a reducing and stabilizing agent. Two fungi ( Aspergillus flavus and Aspergillus fumigatus ) were used for anti-fungal assay. Cell viability, cell cycle analysis, DNA fragmentation, and cell morphology were assessed to determine the toxicity of thiourea-reduced graphene oxide (T-rGO) on human lung cancer cells. The results revealed that GO and T-rGO were hazardous to cells in a dose-dependent trend. The viability of both A. fumigatus and A. flavus was affected by GO and T-rGO. The reactive oxygen species produced by T-rGO caused the death of A. flavus and A. fumigatus cells. This study highlighted the effectiveness of T-rGO as an antifungal agent. In addition, T-rGO was found to be more harmful to cancer cells than GO. Thus, T-rGO manifested great potential in biological and biomedical applications.
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فهرسة مساهمة: Keywords: Aspergillus flavus; DNA fragmentation; antifungal activity; cell viability; lung cancer cells; reduced graphene oxide
تواريخ الأحداث: Date Created: 20230108 Latest Revision: 20230111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9823875
DOI: 10.3390/nano13010149
PMID: 36616058
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-4991
DOI:10.3390/nano13010149