دورية أكاديمية
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Alterations in prefrontal cortical neuregulin-1 levels in post-pubertal rats with neonatal ventral hippocampal lesions.

التفاصيل البيبلوغرافية
العنوان: Alterations in prefrontal cortical neuregulin-1 levels in post-pubertal rats with neonatal ventral hippocampal lesions.
المؤلفون: Watanabe K; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.; Department of Pharmacy, Fukushima Medical University Hospital, Fukushima, Japan., Nakagawasai O; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Kanno SI; Division of Clinical Pharmaceutical Therapy, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Mitazaki S; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.; Laboratory of Forensic Toxicology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki-shi, Japan., Onogi H; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.; Faculty of Health Science, Tohoku Fukushi University, Sendai, Japan., Takahashi K; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Otawara, Tochigi, Japan., Watanabe KI; Center for Research on Counseling and Support Services, The University of Tokyo, Bunkyō-ku, Tokyo, Japan., Tan-No K; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Ishikawa M; Division of Clinical Pharmaceutical Therapy, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Srivastava LK; Douglas Hospital Research Centre, McGill University, Montreal, QC, Canada., Quirion R; Douglas Hospital Research Centre, McGill University, Montreal, QC, Canada., Tadano T; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.; Complementary and Alternative Medicine Clinical Research and Development, Graduate School of Medicine Sciences, Kanazawa University, Kanazawa, Japan.
المصدر: Frontiers in behavioral neuroscience [Front Behav Neurosci] 2022 Dec 22; Vol. 16, pp. 1008623. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477952 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5153 (Print) Linking ISSN: 16625153 NLM ISO Abbreviation: Front Behav Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
مستخلص: Genetic studies in humans have implicated the gene encoding neuregulin-1 (NRG-1) as a candidate susceptibility gene for schizophrenia. Furthermore, it has been suggested that NRG-1 is involved in regulating the expression and function of the N -methyl-D-aspartate receptor and the GABA A receptor in several brain areas, including the prefrontal cortex (PFC), the hippocampus, and the cerebellum. Neonatal ventral hippocampal lesioned (NVHL) rats have been considered as a putative model for schizophrenia with characteristic post-pubertal alteration in response to stress and neuroleptics. In this study, we examined NRG-1, erb-b2 receptor tyrosine kinase 4 (erbB4), and phospho-erbB4 (p-erbB4) levels in the PFC and the distribution of NRG-1 in the NVHL rats by using immunoblotting and immunohistochemical analyses. Neonatal lesions were induced by bilateral injection of ibotenic acid in the ventral hippocampus of postnatal day 7 Sprague-Dawley (SD)-rats. NVHL rats showed significantly decreased levels of NRG-1 and p-erbB4 in the PFC compared to sham controls at post-pubertal period, while the level of erbB4 did not differ between sham and NVHL rats. Moreover, microinjection of NRG-1 into the mPFC improved NVHL-induced prepulse inhibition deficits. Our study suggests PFC NRG-1 alteration as a potential mechanism in schizophrenia-like behaviors in the NVHL model.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Watanabe, Nakagawasai, Kanno, Mitazaki, Onogi, Takahashi, Watanabe, Tan-No, Ishikawa, Srivastava, Quirion and Tadano.)
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فهرسة مساهمة: Keywords: erbB4; neonatal ventral hippocampal lesion; neuregulin-1; prefrontal cortex; prepulse inhibition; schizophrenia
تواريخ الأحداث: Date Created: 20230109 Latest Revision: 20230111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9813588
DOI: 10.3389/fnbeh.2022.1008623
PMID: 36620856
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-5153
DOI:10.3389/fnbeh.2022.1008623