دورية أكاديمية
Enhanced fluorimetric detection of diphenylpyraline HCl using micelle and cyclodextrin mediated approach: Spectrofluorimetric and micellar liquid chromatographic application for either single or combined formulation with caffeine and paracetamol.
| العنوان: | Enhanced fluorimetric detection of diphenylpyraline HCl using micelle and cyclodextrin mediated approach: Spectrofluorimetric and micellar liquid chromatographic application for either single or combined formulation with caffeine and paracetamol. |
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| المؤلفون: | Hammad SF; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, The Medical Campus of Tanta University, Elgeish Street, Tanta 31111, Egypt., El-Malla SF; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, The Medical Campus of Tanta University, Elgeish Street, Tanta 31111, Egypt., El-Khateeb BZ; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, The Medical Campus of Tanta University, Elgeish Street, Tanta 31111, Egypt. Electronic address: basma.elkhateeb@pharm.tanta.edu.eg. |
| المصدر: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2023 Apr 15; Vol. 291, pp. 122317. Date of Electronic Publication: 2023 Jan 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Kidlington, Oxford, U.K. ; Tarrytown, NY] : Pergamon, c1994- |
| مواضيع طبية MeSH: | Acetaminophen*/analysis , Micelles*, Humans ; Caffeine/analysis ; Spectrometry, Fluorescence ; Indicators and Reagents ; Tablets/chemistry |
| مستخلص: | Highly sensitive micellar spectrofluorimetric method (Method I) has been developed and validated for the determination of diphenylpyraline HCl in pharmaceutical tablets and in plasma. Sodium dodecyl sulfate improves the intensity of fluorescence of diphenylpyraline at 286 nm at pH 5 that allow its determination in plasma at nano-level. the mean percent recovery ± S.D was 99.719 ± 0.338 in plasma. In addition, Green cyclodextrin-modified micellar liquid chromatographic method (Method II) has been developed and validated for simultaneous determination of diphenylpyraline, paracetamol and caffeine using cyclodextrin micellar mobile phase consisted of 30 mM Brij*35, 0.5 mM hydroxypropyl β-cyclodextrin and phosphate buffer pH 4: MeOH (95:5, %v/v) that allows their simultaneous determination with enhanced spectrofluorimetric detection of diphenylpyraline. Method II was effectively applied for the simultaneous determination of diphenylpyraline, paracetamol and caffeine in a ternary laboratory prepared mixture which contained all possible excipients with mean percent recoveries ± S.D of 100.176 ± 1.008, 101.166 ± 0.415 and 100.708 ± 1.836, respectively. Linearity range for Method I was 0.1-1 μg. mL -1 for diphenylpyraline and for Method II was 0.3-50, 25-350, and 0.5-50 for caffeine, paracetamol and diphenylpyraline, respectively. Method I was also applied in spiked human plasma with linearity range 0.2-0.5 μg. mL -1 . The methods are verified to have excellent greenness. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Analytical eco-scale; Caffeine; Cyclodextrin micellar liquid chromatography; Diphenylpyraline HCl; Micelle-enhanced spectrofluorometry; Paracetamol |
| المشرفين على المادة: | 362O9ITL9D (Acetaminophen) 0 (Micelles) 3G6A5W338E (Caffeine) 33361OE3AV (diphenylpyraline) 0 (Indicators and Reagents) 0 (Tablets) |
| تواريخ الأحداث: | Date Created: 20230109 Date Completed: 20230223 Latest Revision: 20230223 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.saa.2023.122317 |
| PMID: | 36621026 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3557 |
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| DOI: | 10.1016/j.saa.2023.122317 |