دورية أكاديمية
أعرض في EDS

HLA expression as a risk factor for metastases of cutaneous squamous-cell carcinoma in organ- transplant recipients.

التفاصيل البيبلوغرافية
العنوان: HLA expression as a risk factor for metastases of cutaneous squamous-cell carcinoma in organ- transplant recipients.
المؤلفون: de Jong E; Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address: e.de_jong.huid@lumc.nl., Quint KD; Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands., El Ghalbzouri A; Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands., Verdijk RM; Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; Department of Pathology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, the Netherlands., Goeman JJ; Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands., Heidt S; Department of Immunology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands., Claas FHJ; Department of Immunology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands., de Fijter JW; Department of Internal Medicine (Nephrology), Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands., Genders RE; Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands., Vermeer MH; Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands., Bouwes Bavinck JN; Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.
المصدر: Human immunology [Hum Immunol] 2023 Mar; Vol. 84 (3), pp. 208-213. Date of Electronic Publication: 2023 Jan 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 8010936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1166 (Electronic) Linking ISSN: 01988859 NLM ISO Abbreviation: Hum Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [New York] Elsevier/North-Holland.
مواضيع طبية MeSH: Carcinoma, Squamous Cell*/genetics , Carcinoma, Squamous Cell*/pathology , Skin Neoplasms*/genetics , Skin Neoplasms*/pathology , HLA Antigens*/genetics, Humans ; Immunity ; Risk Factors ; Transplant Recipients
مستخلص: Background: Solid organ-transplant recipients (SOTR) have an increased risk of cutaneous squamous-cell carcinoma (cSCC), metastasis and death from cSCC. In immunocompetent patients with mucosal SCC, downregulation of HLA class I is associated with poor prognosis. Since the degree of HLA expression on tumor cells could play a role in immunogenicity and pathophysiology of cSCC metastasis, we hypothesized that decreased HLA expression is associated with an increased risk of metastasis.
Methods: We compared HLA expression between primary metastasized cSCCs, their metastases, and non-metastasized cSCCs from the same patients. Samples were stained for HLA-A, HLA-B/-C and quantified by calculating the difference in immunoreactivity score (IRS) of the primary cSCC compared with all non-metastasized cSCCs.
Results: The mean IRS score for HLA-B/C expression was 2.07 point higher in metastasized compared to non-metastasized cSCCs (p = 0.065, 95 % CI -0.18-4.32). 83.3 % of the primary metastasized cSCCs had an IRS score of 4 or higher, compared to 42.9 % in non-metastasized cSCCs. Moderately to poorly differentiated cSCCs had more HLA class I expression compared to well-differentiated cSCCs.
Conclusion: Contrary to immunocompetent patients, HLA-B/C expression tends to be upregulated in metastasized cSCC compared to non-metastasized cSCC in SOTR, suggesting that different tumor escape mechanisms play a role in SOTR compared to immunocompetent patients.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: HLA expression; Human leukocyte antigen; Metastasis; Organ transplantation; Squamous cell carcinoma
المشرفين على المادة: 0 (HLA Antigens)
تواريخ الأحداث: Date Created: 20230109 Date Completed: 20230324 Latest Revision: 20230324
رمز التحديث: 20231215
DOI: 10.1016/j.humimm.2022.12.002
PMID: 36621381
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1166
DOI:10.1016/j.humimm.2022.12.002