دورية أكاديمية
Adverse childhood experiences are associated with vascular changes in adolescents that are risk factors for future cardiovascular disease.
العنوان: | Adverse childhood experiences are associated with vascular changes in adolescents that are risk factors for future cardiovascular disease. |
---|---|
المؤلفون: | Kellum CE; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA., Kemp KM; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA., Mrug S; Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA., Pollock JS; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA. jenniferpollock@uabmc.edu., Seifert ME; Division of Nephrology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA., Feig DI; Division of Nephrology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA. |
المصدر: | Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2023 Jul; Vol. 38 (7), pp. 2155-2163. Date of Electronic Publication: 2023 Jan 09. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Berlin : Springer International Original Publication: Berlin : Springer International, c1987- |
مواضيع طبية MeSH: | Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/etiology , Adverse Childhood Experiences* , Child Abuse*, Humans ; Adolescent ; Child ; Pilot Projects ; Risk Factors |
مستخلص: | Background: Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, are associated with a higher risk of cardiovascular disease (CVD) and indicators of future CVD risk in adulthood, such as greater vascular stiffness. The impact of ACEs in adolescence is unclear, and understanding how ACEs relate to blood pressure (BP) and vascular function during early life is key for the development of prevention strategies to reduce CVD risk. We hypothesized that exposure to ACEs would be associated with changes in central hemodynamics such as increased vascular stiffness and higher BP during adolescence. Methods: This pilot study enrolled 86 adolescents recruited from the Children's of Alabama. A validated ACE questionnaire was employed, and ACEs were modeled both as a continuous variable and a categorical variable (ACE ≥ 1 vs. ACE = 0). The primary outcomes used are considered to be indicators of future cardio-renal disease risk: aortic augmentation index normalized to 75 bpm (Alx75, a surrogate for vascular stiffness), carotid-femoral PWV (m/s), and ambulatory BP patterns. Results: Adolescents with ACE ≥ 1 had significantly higher Alx75 (ACE: 5.2% ± 2.2 compared to no ACE: - 1.4% ± 3.0; p = 0.043). PWV only reflected this trend when adjustments were made for the body mass index. Adolescents with ACEs showed no differences in ambulatory BP patterns during the 24-h, wake, or sleep periods compared to adolescents with no ACEs. Conclusions: ACEs were associated with higher AIx75 in adolescence, which is a risk factor for future CVD. Adolescence could present an opportunity for early detections/interventions to mitigate adverse cardiovascular outcomes in adulthood. A higher resolution version of the Graphical abstract is available as Supplementary information. (© 2022. The Author(s).) |
References: | Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS (1998) Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study. Am J Prev Med 14:245–258. https://doi.org/10.1016/S0749-3797(98)00017-8. (PMID: 10.1016/S0749-3797(98)00017-89635069) Ozieh MN, Garacci E, Campbell JA, Walker RJ, Egede LE (2020) Adverse childhood experiences and decreased renal function: impact on all-cause mortality in U.S. adults. Am J Prev Med 59:e49–e57. https://doi.org/10.1016/j.amepre.2020.04.005. (PMID: 10.1016/j.amepre.2020.04.005326902027378887) Su S, Wang X, Kapuku GK, Treiber FA, Pollock DM, Harshfield GA, McCall WV, Pollock JS (2014) Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults. Hypertension 64:201–207. https://doi.org/10.1161/HYPERTENSIONAHA.113.02755. (PMID: 10.1161/HYPERTENSIONAHA.113.0275524777980) Pierce JB, Kershaw KN, Kiefe CI, Jacobs DR, Sidney S, Merkin SS, Feinglass J (2020) Association of childhood psychosocial environment with 30-year cardiovascular disease incidence and mortality in middle age. J Am Heart Assoc 9:131–132. https://doi.org/10.1161/JAHA.119.015326. (PMID: 10.1161/JAHA.119.015326) Su S, Wang X, Pollock JS, Treiber FA, Xu X, Snieder H, McCall WV, Stefanek M, Harshfield GA (2015) Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood the Georgia stress and heart study. Circulation 131:1674–1681. https://doi.org/10.1161/CIRCULATIONAHA.114.013104. (PMID: 10.1161/CIRCULATIONAHA.114.013104258581964430378) Klassen SA, Chirico D, O’Leary DD, Cairney J, Wade TJ (2016) Linking systemic arterial stiffness among adolescents to adverse childhood experiences. Child Abus Negl 56:1–10. https://doi.org/10.1016/j.chiabu.2016.04.002. (PMID: 10.1016/j.chiabu.2016.04.002) Alves C, Pinho JF, Dos Santos LM, Magalhães G, da Silva JM, Fontes FL, Caligiorne SM, Pinheiro S, Rodrigues-Machado MG (2020) Augmentation index, a predictor of cardiovascular events, is increased in children and adolescents with primary nephrotic syndrome. Pediatr Nephrol 35:815–827. https://doi.org/10.1007/S00467-019-04434-0/TABLES/5. (PMID: 10.1007/S00467-019-04434-0/TABLES/531845056) Pierce GL, Zhu H, Darracott K, Edet I, Bhagatwala J, Huang Y, Dong Y (2013) Arterial stiffness and pulse-pressure amplification in overweight/obese African-American adolescents: relation with higher systolic and pulse pressure. Am J Hypertension 26:20–26. https://doi.org/10.1093/AJH/HPS014. (PMID: 10.1093/AJH/HPS014) London GM, Blacher J, Pannier B, Guérin AP, Marchais SJ, Safar ME (2001) Arterial wave reflections and survival in end-stage renal failure. Hypertension 38:434–438. https://doi.org/10.1161/01.HYP.38.3.434. (PMID: 10.1161/01.HYP.38.3.43411566918) Flynn JT, Daniels SR, Hayman LL, Maahs DM, McCrindle BW, Mitsnefes M, Zachariah JP, Urbina EM (2014) Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association. Hypertension 63:1116–1135. https://doi.org/10.1161/HYP.0000000000000007. (PMID: 10.1161/HYP.000000000000000724591341) Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, De Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simase M, Thaker VV, Urbina EM, Okechukwu K (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140:e20171904. https://doi.org/10.1542/PEDS.2017-1904/38358. (PMID: 10.1542/PEDS.2017-1904/3835828827377) Barletta GM, Pierce C, Mitsnefes M, Samuels J, Warady BA, Furth S, Flynn J (2018) Is blood pressure improving in children with chronic kidney disease? A period analysis. Hypertension 71:444–450. https://doi.org/10.1161/HYPERTENSIONAHA.117.09649. (PMID: 10.1161/HYPERTENSIONAHA.117.0964929295853) Wilkinson IB, MacCallum H, Flint L, Cockcroft JR, Newby DE, Webb DJ (2000) The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol 525:263. https://doi.org/10.1111/J.1469-7793.2000.T01-1-00263.X. (PMID: 10.1111/J.1469-7793.2000.T01-1-00263.X108117422269933) R Core Team (2020) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/. Kreatsoulas C, Fleegler EW, Kubzansky LD, McGorrian CM, Subramanian SV (2019) Young adults and adverse childhood events: a potent measure of cardiovascular risk. Am J Med 132:605–613. https://doi.org/10.1016/j.amjmed.2018.12.022. (PMID: 10.1016/j.amjmed.2018.12.02230639555) Stabouli S, Kollios K, Nika T, Chrysaidou K, Tramma D, Kotsis V (2020) Ambulatory hemodynamic patterns, obesity, and pulse wave velocity in children and adolescents. Pediatr Nephrol 35:2335–2344. https://doi.org/10.1007/s00467-020-04694-1. (PMID: 10.1007/s00467-020-04694-132661605) Kulsum-Mecci N, Goss C, Kozel BA, Garbutt JM, Schechtman KB, Dharnidharka VR (2017) Effects of obesity and hypertension on pulse wave velocity in children. J Clin Hypertension 19:221. https://doi.org/10.1111/JCH.12892. (PMID: 10.1111/JCH.12892) Jakubowski KP, Cundiff JM, Matthews KA (2018) Cumulative childhood adversity and adult cardiometabolic disease: a meta-analysis. Heal Psychol 37:701–715. https://doi.org/10.1037/HEA0000637. (PMID: 10.1037/HEA0000637) Takase H, Dohi Y, Toriyama T, Okado T, Tanaka S, Sonoda H, Sato K, Kimura G (2011) Brachial-ankle pulse wave velocity predicts increase in blood pressure and onset of hypertension. Am J Hypertens 24:667–673. https://doi.org/10.1038/ajh.2011.19. (PMID: 10.1038/ajh.2011.1921331056) Najjar SS, Scuteri A, Shetty V, Wright JG, Muller DC, Fleg JL, Spurgeon HP, Ferrucci L, Lakatta EG (2008) Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore longitudinal study of aging. J Am Coll Cardiol 51:1377–1383. https://doi.org/10.1016/j.jacc.2007.10.065. (PMID: 10.1016/j.jacc.2007.10.065183874402771854) Koivistoinen T, Lyytikäinen LP, Aatola H, Luukkaala T, Juonala M, Viikari J, Lehtimäki T, Raitakari OT, Kähönen M, Hutri-Kähönen N (2018) Pulse wave velocity predicts the progression of blood pressure and development of hypertension in young adults. Hypertension 71:451–456. https://doi.org/10.1161/HYPERTENSIONAHA.117.10368. (PMID: 10.1161/HYPERTENSIONAHA.117.1036829311251) Zachariah JP, Wang Y, Newburger JW, Deferranti SD, Mitchell GF, Vasan RS (2021) Biological pathways in adolescent aortic stiffness. J Am Heart Assoc 10:e018419. https://doi.org/10.1161/JAHA.120.018419. (PMID: 10.1161/JAHA.120.018419336413508174212) Aggoun Y, Farpour-Lambert NJ, Marchand LM, Golay E, Maggio ABR, Beghetti M (2008) Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure. Eur Heart J 29:792–799. https://doi.org/10.1093/EURHEARTJ/EHM633. (PMID: 10.1093/EURHEARTJ/EHM63318245115) Levent E, Ozyürek AR, Ülger Z (2004) Evaluation of aortic stiffness in tobacco-smoking adolescents. J Adolesc Heal 34:339–343. https://doi.org/10.1016/J.JADOHEALTH.2003.07.012. (PMID: 10.1016/J.JADOHEALTH.2003.07.012) Rafiq T, O’Leary DD, Dempster KS, Cairney J, Wade TJ (2020) Adverse childhood experiences (ACEs) predict increased arterial stiffness from childhood to early adulthood: pilot analysis of the Niagara Longitudinal Heart Study. J Child Adolesc Trauma 13:505–514. https://doi.org/10.1007/s40653-020-00311-3. (PMID: 10.1007/s40653-020-00311-3332690497683677) McEniery CM, Yasmin HIR, Qasem A, Wilkinson IB, Cockcroft JR (2005) Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol 46:1753–1760. https://doi.org/10.1016/J.JACC.2005.07.037. (PMID: 10.1016/J.JACC.2005.07.03716256881) Lowenthal A, Evans JMA, Punn R, Nourse SE, Vu C, Popat RA, Tierney ESS (2014) Arterial applanation tonometry: feasibility and reproducibility in children and adolescents. Am J Hypertens 27:1218–1224. https://doi.org/10.1093/ajh/hpu034. (PMID: 10.1093/ajh/hpu034246274454184354) Nürnberger J, Keflioglu-Scheiber A, Opazo Saez AM, Wenzel RR, Philipp T, Schäfers RF (2002) Augmentation index is associated with cardiovascular risk. J Hypertension 20:2407–2414. https://doi.org/10.1097/00004872-200212000-00020. (PMID: 10.1097/00004872-200212000-00020) Dos SLM, Gomes IC, Pinho JF, Neves-Alves CM, Magalhães GS, Campagnole-Santos MJ, Rodrigues-Machado MG (2021) Predictors and reference equations for augmentation index, an arterial stiffness marker, in healthy children and adolescents. Clinics (Sao Paulo) 76:e2350. https://doi.org/10.6061/clinics/2021/e2350. (PMID: 10.6061/clinics/2021/e2350) Hudson LD, Rapala A, Khan T, Williams B, Viner RM (2015) Evidence for contemporary arterial stiffening in obese children and adolescents using pulse wave velocity: a systematic review and meta-analysis. Atherosclerosis 241:376–386. https://doi.org/10.1016/j.atherosclerosis.2015.05.014. (PMID: 10.1016/j.atherosclerosis.2015.05.01426071661) Garcia-Espinosa V, Bia D, Castro J, Zinoveev A, Marin M, Giachetto G, Chiesa P, Zócalo Y (2018) Peripheral and central aortic pressure, wave-derived reflection parameters, local and regional arterial stiffness and structural parameters in children and adolescents: impact of body mass index variations. High Blood Press Cardiovasc Prev 25:267–280. https://doi.org/10.1007/S40292-018-0264-1. (PMID: 10.1007/S40292-018-0264-129968145) Lurbe E, Torro I, Garcia-Vicent C, Alvarez J, Fernández-Fornoso JA, Redon J (2012) Blood pressure and obesity exert independent influences on pulse wave velocity in youth. Hypertension 60:550–555. https://doi.org/10.1161/HYPERTENSIONAHA.112.194746. (PMID: 10.1161/HYPERTENSIONAHA.112.19474622733475) Köchli S, Deiseroth A, Hauser C, Streese L, Schmidt-Trucksäss A, Faude O, Hanssen H (2021) Body composition and physical fitness affect central hemodynamics in young children. Front Pediatr 9:750398. https://doi.org/10.3389/FPED.2021.750398/FULL. (PMID: 10.3389/FPED.2021.750398/FULL347781418578851) Tomsa A, Klinepeter Bartz S, Krishnamurthy R, Krishnamurthy R, Bacha F (2016) Endothelial function in youth: a biomarker modulated by adiposity-related insulin resistance. J Pediatr 178:171–177. https://doi.org/10.1016/J.JPEDS.2016.07.025. (PMID: 10.1016/J.JPEDS.2016.07.02527546204) Rippe JM (2019) Lifestyle strategies for risk factor reduction, prevention, and treatment of cardiovascular disease. Am J Lifestyle Med 13:204. https://doi.org/10.1177/1559827618812395. (PMID: 10.1177/155982761881239530800027) Schmieder RE (2010) End organ damage in hypertension. Dtsch Arztebl Int 107:866. https://doi.org/10.3238/arztebl.2010.0866. (PMID: 10.3238/arztebl.2010.0866211915473011179) Riley E, Wright R, Jun H, Hibert EN, Rich-Edwards JW (2010) Hypertension in adult survivors of child abuse: observations from the Nurses’ Health Study II. J Epidemiol Community Health 64:413. https://doi.org/10.1136/JECH.2009.095109. (PMID: 10.1136/JECH.2009.09510920445210) Gooding HC, Milliren C, McLaughlin KA, Richmond TK, Katz-Wise SL, Rich-Edwards J, Austin SB (2014) Child maltreatment and blood pressure in young adulthood. Child Abuse Negl 38:1747–1754. https://doi.org/10.1016/J.CHIABU.2014.08.019. (PMID: 10.1016/J.CHIABU.2014.08.019252455014254185) Suglia SF, Appleton AA, Bleil ME, Campo RA, Dube SR, Fagundes CP, Heard-Garris NJ, Johnson SB, Slopen N, Stoney CM, Watamura SE (2021) Timing, duration, and differential susceptibility to early life adversities and cardiovascular disease risk across the lifespan: implications for future research. Prev Med 153:106736. https://doi.org/10.1016/J.YPMED.2021.106736. (PMID: 10.1016/J.YPMED.2021.106736342933818595689) Lee RD, Chen J (2017) Adverse childhood experiences, mental health, and excessive alcohol use: examination of race/ethnicity and sex differences. Child Abus Negl 69:40–48. https://doi.org/10.1016/j.chiabu.2017.04.004. (PMID: 10.1016/j.chiabu.2017.04.004) Andrade JL, Hong Y-R, Lee AM, Miller DR, Williams C, Thompson LA, Bright MA, Cardel MI (2021) Adverse childhood experiences are associated with cardiometabolic risk among Hispanic American adolescents. J Pediatr 237:267-275.e1. https://doi.org/10.1016/j.jpeds.2021.06.024. (PMID: 10.1016/j.jpeds.2021.06.02434147498) Negriff S (2020) ACEs are not equal: examining the relative impact of household dysfunction versus childhood maltreatment on mental health in adolescence. Soc Sci Med 245:112696. https://doi.org/10.1016/j.socscimed.2019.112696. (PMID: 10.1016/j.socscimed.2019.11269631785426) Ehrlich KB, Ross KM, Chen E, Miller GE (2016) Testing the biological embedding hypothesis: is early life adversity associated with a later proinflammatory phenotype? Dev Psychopathol 28:1273–1283. https://doi.org/10.1017/S0954579416000845. (PMID: 10.1017/S0954579416000845276919815475361) Danese A, Pariante CM, Caspi A, Taylor A, Poulton R (2007) Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci U S A 104:1319–1324. https://doi.org/10.1073/pnas.0610362104. (PMID: 10.1073/pnas.0610362104172298391783123) Ridker PM (2016) From CRP to IL-6 to IL-1: moving upstream to identify novel targets for atheroprotection. Circ Res 118:145. https://doi.org/10.1161/CIRCRESAHA.115.306656. (PMID: 10.1161/CIRCRESAHA.115.306656268377454793711) |
معلومات مُعتمدة: | P01 HL158500 United States HL NHLBI NIH HHS; R25 DK115353 United States DK NIDDK NIH HHS; K12 GM088010 United States GM NIGMS NIH HHS; T32 DK116672 United States DK NIDDK NIH HHS |
فهرسة مساهمة: | Keywords: Adolescence; Adverse childhood experience; Aortic augmentation index; Blood pressure; Early life stress |
تواريخ الأحداث: | Date Created: 20230109 Date Completed: 20230605 Latest Revision: 20231128 |
رمز التحديث: | 20231128 |
مُعرف محوري في PubMed: | PMC10234926 |
DOI: | 10.1007/s00467-022-05853-2 |
PMID: | 36622441 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-198X |
---|---|
DOI: | 10.1007/s00467-022-05853-2 |