دورية أكاديمية
أعرض في EDS

Adverse childhood experiences are associated with vascular changes in adolescents that are risk factors for future cardiovascular disease.

التفاصيل البيبلوغرافية
العنوان: Adverse childhood experiences are associated with vascular changes in adolescents that are risk factors for future cardiovascular disease.
المؤلفون: Kellum CE; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA., Kemp KM; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA., Mrug S; Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA., Pollock JS; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA. jenniferpollock@uabmc.edu., Seifert ME; Division of Nephrology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA., Feig DI; Division of Nephrology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA.
المصدر: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2023 Jul; Vol. 38 (7), pp. 2155-2163. Date of Electronic Publication: 2023 Jan 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer International
Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH: Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/etiology , Adverse Childhood Experiences* , Child Abuse*, Humans ; Adolescent ; Child ; Pilot Projects ; Risk Factors
مستخلص: Background: Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, are associated with a higher risk of cardiovascular disease (CVD) and indicators of future CVD risk in adulthood, such as greater vascular stiffness. The impact of ACEs in adolescence is unclear, and understanding how ACEs relate to blood pressure (BP) and vascular function during early life is key for the development of prevention strategies to reduce CVD risk. We hypothesized that exposure to ACEs would be associated with changes in central hemodynamics such as increased vascular stiffness and higher BP during adolescence.
Methods: This pilot study enrolled 86 adolescents recruited from the Children's of Alabama. A validated ACE questionnaire was employed, and ACEs were modeled both as a continuous variable and a categorical variable (ACE ≥ 1 vs. ACE = 0). The primary outcomes used are considered to be indicators of future cardio-renal disease risk: aortic augmentation index normalized to 75 bpm (Alx75, a surrogate for vascular stiffness), carotid-femoral PWV (m/s), and ambulatory BP patterns.
Results: Adolescents with ACE ≥ 1 had significantly higher Alx75 (ACE: 5.2% ± 2.2 compared to no ACE: - 1.4% ± 3.0; p = 0.043). PWV only reflected this trend when adjustments were made for the body mass index. Adolescents with ACEs showed no differences in ambulatory BP patterns during the 24-h, wake, or sleep periods compared to adolescents with no ACEs.
Conclusions: ACEs were associated with higher AIx75 in adolescence, which is a risk factor for future CVD. Adolescence could present an opportunity for early detections/interventions to mitigate adverse cardiovascular outcomes in adulthood. A higher resolution version of the Graphical abstract is available as Supplementary information.
(© 2022. The Author(s).)
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معلومات مُعتمدة: P01 HL158500 United States HL NHLBI NIH HHS; R25 DK115353 United States DK NIDDK NIH HHS; K12 GM088010 United States GM NIGMS NIH HHS; T32 DK116672 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Adolescence; Adverse childhood experience; Aortic augmentation index; Blood pressure; Early life stress
تواريخ الأحداث: Date Created: 20230109 Date Completed: 20230605 Latest Revision: 20231128
رمز التحديث: 20231128
مُعرف محوري في PubMed: PMC10234926
DOI: 10.1007/s00467-022-05853-2
PMID: 36622441
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-198X
DOI:10.1007/s00467-022-05853-2