دورية أكاديمية
Differences in mirex [dechlorane] and dechlorane plus [syn- and anti-] concentrations observed in Canadian human milk.
| العنوان: | Differences in mirex [dechlorane] and dechlorane plus [syn- and anti-] concentrations observed in Canadian human milk. |
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| المؤلفون: | Rawn DFK; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada. Electronic address: thea.rawn@hc-sc.gc.ca., Quade SC; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada., Corrigan C; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada., Ménard C; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada., Sun WF; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada., Breton F; Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada; Generic Drugs Division, Bureau of Pharmaceutical Sciences, Health Products and Food Branch, Health Canada, 101 Tunney's Pasture Driveway, Address Locator: 0201D, Tunney's Pasture, Ottawa, ON, K1A 0K9, Canada., Arbuckle TE; Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Address Locator: 0801A, Ottawa, ON, K1A 0K9, Canada., Fraser WD; CHU Sainte-Justine, Centre de Recherche, Université de Montréal, Montréal, QC, Canada. |
| المصدر: | Chemosphere [Chemosphere] 2023 Mar; Vol. 316, pp. 137784. Date of Electronic Publication: 2023 Jan 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مواضيع طبية MeSH: | Flame Retardants*/analysis , Hydrocarbons, Chlorinated*/analysis , Polycyclic Compounds*/analysis, Female ; Humans ; Mirex ; Environmental Monitoring/methods ; Milk, Human/chemistry ; Canada |
| مستخلص: | As part of the pan-Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) study, human milk samples were collected between 2008 and 2011, and analyzed for mirex, an organochlorine insecticide and flame retardant, in addition to dechlorane plus (syn- and anti-DDC-CO), the flame retardant replacement for mirex. Mirex was analyzed separately, using a method for the analysis of existing organochlorine insecticides, while the presence of DDC-CO isomers was determined using a method developed for the detection of emerging flame retardants. Mirex was detected in all samples analyzed (n = 298), while syn- and anti-DDC-CO were present in 61.0% and 79.5% of the samples, respectively (n = 541). Mirex concentrations have declined in human milk since the 1990s. Since this is the first pan-Canadian dataset reporting DDC-CO concentrations in human milk, no temporal comparisons can be made. Maternal age was correlated with concentrations of both compounds although parity did not impact concentrations of either analyte. Given the presence of this relatively recently identified flame retardant (DDC-CO) in human milk from women across Canada, studies to identify dominant sources of this compound are critical. Despite low concentrations of environmental chemicals in human milk from Canadian women, Health Canada supports breastfeeding of infants because of the important health benefits to both the mothers and their infants. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Crown Copyright © 2023. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chlorinated compounds; GC-MS; Gas chromatography-high resolution mass spectrometry; Human milk |
| المشرفين على المادة: | Z917AN264P (Mirex) 0 (dechlorane plus) 0 (Flame Retardants) 0 (Hydrocarbons, Chlorinated) 0 (Polycyclic Compounds) |
| تواريخ الأحداث: | Date Created: 20230109 Date Completed: 20230130 Latest Revision: 20230202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.chemosphere.2023.137784 |
| PMID: | 36623597 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1298 |
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| DOI: | 10.1016/j.chemosphere.2023.137784 |