دورية أكاديمية
Lower Number and Percentage of Activated Natural Killer Cells in Colorectal Cancer Patients.
| العنوان: | Lower Number and Percentage of Activated Natural Killer Cells in Colorectal Cancer Patients. |
|---|---|
| المؤلفون: | Vidyani A; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine Universitas Airlangga - Dr. Soetomo Hospital, Surabaya, Indonesia. amie.vidyani@fk.unair.ac.id., Nusi IA, Kholili U, Setiawan PB, Purbayu H, Sugihartono T, Maimunah U, Widodo B, Thamrin H, Miftahussurur M |
| المصدر: | Acta medica Indonesiana [Acta Med Indones] 2022 Oct; Vol. 54 (4), pp. 524-530. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Indonesian Society of Internal Medicine Country of Publication: Indonesia NLM ID: 7901042 Publication Model: Print Cited Medium: Internet ISSN: 0125-9326 (Print) Linking ISSN: 01259326 NLM ISO Abbreviation: Acta Med Indones Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Jakarta, Indonesia : Indonesian Society of Internal Medicine |
| مواضيع طبية MeSH: | Colorectal Neoplasms*/diagnosis, Humans ; Cross-Sectional Studies ; Killer Cells, Natural/pathology ; Colonoscopy |
| مستخلص: | Background: Colorectal cancer is a type of cancer that begins in the colon and/or rectum tissue. Natural killer (NK) cells play a critical role in the first line of defense against infection and tumors, as well as in autoimmunity and hypersensitivity reactions. NK cells also play a role in regulating tumor cell growth and metastasis. The number and percentage of activated natural killer cells have been determined in patients with colorectal cancer and benign lesion. Methods: This was a cross-sectional observational analytic study. The number and percentage of activated NK cells in peripheral blood were determined using the flow cytometry method in 50 samples from patients who underwent colonoscopy and obtained a mass as evidenced by histopathological examination. Results: Among the 50 samples, 24 samples included in the colorectal cancer group and 26 samples from benign lesion group. The mean number of NK cells in colorectal cancer was 161.71 ± 62.666 cells/µL, benign lesion was 553.92 ± 269.173 cells/µL. The mean percentage of activated NK cells in colorectal cancer was 2.82 ± 1.19%, benign lesion was 5.10 ± 2.48%. There was a significant difference in the number of NK cells and the percentage of activated NK cells between colorectal cancer and benign lesion patients (p = 0.000). Conclusion: The number and activity of NK cells decreases in patients with colorectal cancer. |
| فهرسة مساهمة: | Keywords: The number of NK cells; cancer; colorectal cancer; percentage of activated NK cells |
| تواريخ الأحداث: | Date Created: 20230110 Date Completed: 20230111 Latest Revision: 20230111 |
| رمز التحديث: | 20230111 |
| PMID: | 36624721 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0125-9326 |
|---|