دورية أكاديمية
Live Cell Lineage Tracing of Dormant Cancer Cells.
| العنوان: | Live Cell Lineage Tracing of Dormant Cancer Cells. |
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| المؤلفون: | Kim H; Molecular and Cell Biology Graduate Program, University of Massachusetts, Amherst, MA, 01002, USA., Wirasaputra A; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, 01002, USA., Mohammadi F; Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA., Kundu AN; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, 01002, USA., Esteves JAE; Department of Biomedical Engineering, University of Massachusetts, Amherst, MA, 01002, USA., Heiser LM; Department of Biomedical Engineering, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA., Meyer AS; Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, 90095, USA., Peyton SR; Molecular and Cell Biology Graduate Program, University of Massachusetts, Amherst, MA, 01002, USA.; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, 01002, USA.; Department of Biomedical Engineering, University of Massachusetts, Amherst, MA, 01002, USA. |
| المصدر: | Advanced healthcare materials [Adv Healthc Mater] 2023 Jun; Vol. 12 (14), pp. e2202275. Date of Electronic Publication: 2023 Jan 20. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim : Wiley-VCH, 2012- |
| مواضيع طبية MeSH: | Breast Neoplasms*/pathology, Humans ; Female ; Cell Lineage ; Tumor Microenvironment |
| مستخلص: | Breast cancer is a leading cause of global cancer-related deaths, and metastasis is the overwhelming culprit of poor patient prognosis. The most nefarious aspect of metastasis is dormancy, a prolonged period between primary tumor resection and relapse. Current therapies are insufficient at killing dormant cells; thus, they can remain quiescent in the body for decades until eventually undergoing a phenotypic switch, resulting in metastases that are more adaptable and drug resistant. Unfortunately, dormancy has few in vitro models, largely because lab-derived cell lines are highly proliferative. Existing models address tumor dormancy, not cellular dormancy, because tracking individual cells is technically challenging. To combat this problem, a live cell lineage approach to find and track individual dormant cells, distinguishing them from proliferative and dying cells over multiple days, is adapted. This approach is applied across a range of different in vitro microenvironments. This approach reveals that the proportion of cells that exhibit long-term quiescence is regulated by both cell intrinsic and extrinsic factors, with the most dormant cells found in 3D collagen gels. This paper envisions that this approach will prove useful to biologists and bioengineers in the dormancy community to identify, quantify, and study dormant tumor cells. (© 2023 Wiley-VCH GmbH.) |
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| معلومات مُعتمدة: | R21 CA223783 United States CA NCI NIH HHS; T32 GM135096 United States GM NIGMS NIH HHS; DP2 CA186573 United States CA NCI NIH HHS; U01 CA215709 United States CA NCI NIH HHS; U01 CA265709 United States CA NCI NIH HHS; U54 CA209988 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Matrigel; biomaterials; breast cancer; collagen; poly(ethylene glycol) hydrogels |
| تواريخ الأحداث: | Date Created: 20230110 Date Completed: 20230605 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| مُعرف محوري في PubMed: | PMC10238615 |
| DOI: | 10.1002/adhm.202202275 |
| PMID: | 36625629 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2192-2659 |
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| DOI: | 10.1002/adhm.202202275 |