دورية أكاديمية
Checkpoint inhibitor-based salvage regimens prior to autologous stem cell transplant improve event-free survival in relapsed/refractory classic Hodgkin lymphoma.
العنوان: | Checkpoint inhibitor-based salvage regimens prior to autologous stem cell transplant improve event-free survival in relapsed/refractory classic Hodgkin lymphoma. |
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المؤلفون: | Desai SH; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.; Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, USA., Spinner MA; Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, California, USA., David K; Department of Hematology and Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA., Bachanova V; Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, USA.; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Goyal G; O'Neal Comprehensive Cancer Center, University of Alabama, Birmingham, Alabama, USA., Kahl B; Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri, USA., Dorritie K; Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA., Azzi J; Division of Hematology and Medical Oncology, Icahn School of Medicine Mount Sinai, New York, New York, USA., Kenkre VP; Department of Hematology, University of Wisconsin, Madison, Wisconsin, USA., Arai S; Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, California, USA., Chang C; Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, California, USA., Fusco B; Department of Hematology and Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA., Sumransub N; Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, USA.; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Hatic H; O'Neal Comprehensive Cancer Center, University of Alabama, Birmingham, Alabama, USA., Saba R; Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri, USA., Ibrahim U; Division of Hematology and Medical Oncology, Icahn School of Medicine Mount Sinai, New York, New York, USA., Harris EI; Department of Hematology, University of Wisconsin, Madison, Wisconsin, USA., Shah H; Division of Hematology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Murphy J; Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA., Ansell S; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA., Jagadish D; Cleveland Clinic Foundation, Cleveland, Ohio, USA., Orellana-Noia V; Division of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Diefenbach C; Perlmutter Cancer Center, NYU Grossman Medical School, New York, New York, USA., Iyenger S; Division of Hematology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Rappazzo KC; Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA., Mishra R; Cleveland Clinic Foundation, Cleveland, Ohio, USA., Choi Y; Perlmutter Cancer Center, NYU Grossman Medical School, New York, New York, USA., Nowakowski GS; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA., Advani RH; Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, California, USA., Micallef IN; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA. |
المصدر: | American journal of hematology [Am J Hematol] 2023 Mar; Vol. 98 (3), pp. 464-471. Date of Electronic Publication: 2023 Jan 11. |
نوع المنشور: | Multicenter Study; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-8652 (Electronic) Linking ISSN: 03618609 NLM ISO Abbreviation: Am J Hematol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York Ny : Wiley-Blackwell Original Publication: New York, Liss. |
مواضيع طبية MeSH: | Hodgkin Disease*/drug therapy , Hodgkin Disease*/pathology , Hematopoietic Stem Cell Transplantation*, Humans ; Progression-Free Survival ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Brentuximab Vedotin/therapeutic use ; Stem Cell Transplantation ; Transplantation, Autologous ; Salvage Therapy |
مستخلص: | Clinical trials of novel salvage therapies have encouraging outcomes for relapsed/refractory transplant-eligible classic Hodgkin lymphoma (R/R cHL) but comparison with conventional chemotherapy is lacking. Herein, we report the final analysis of a multicenter retrospective cohort of R/R cHL assessing outcomes by type of salvage therapy before autologous stem cell transplant (ASCT). R/R cHL patients who underwent ASCT at 14 institutions across the United States were included. Outcomes were compared among patients receiving conventional chemotherapy, brentuximab vedotin (BV) + chemotherapy, BV alone, and a checkpoint inhibitor (CPI)-based regimens before ASCT. Study endpoints included event-free survival (EFS), progression-free survival (PFS), and overall survival (OS). All endpoints are defined from relapse. Of 936 patients, 728 received conventional chemotherapy, 73 received BV + chemotherapy, 70 received BV alone, and 65 received CPI-based regimens prior to ASCT. When adjusted for time to relapse, pre-ASCT response and use of BV maintenance, patients receiving CPI-based regimens had superior 2-year EFS compared to conventional chemotherapy, BV + chemotherapy, and BV alone (79.7, 49.6, 62.3, and 36.9%, respectively, p < .0001). Among 649 patients transplanted after 1 line of salvage therapy, CPI-based regimens were associated with superior 2-year PFS compared to conventional chemotherapy (98% vs. 68.8%, hazard ratio: 0.1, 95% confidence interval: 0.03-0.5, p < .0001). OS did not differ by pre-ASCT salvage regimen. In this large multicenter retrospective study, CPI-based regimens improved EFS and PFS compared to other salvage regimens independent of pre-ASCT response. These data support earlier sequencing of CPI-based regimens in R/R cHL in the pre-ASCT setting. (© 2023 Wiley Periodicals LLC.) |
التعليقات: | Erratum in: Am J Hematol. 2023 Nov;98(11):1818. doi: 10.1002/ajh.27103. (PMID: 37732813) |
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معلومات مُعتمدة: | P30 CA047904 United States CA NCI NIH HHS |
المشرفين على المادة: | 7XL5ISS668 (Brentuximab Vedotin) |
تواريخ الأحداث: | Date Created: 20230111 Date Completed: 20230216 Latest Revision: 20240711 |
رمز التحديث: | 20240711 |
مُعرف محوري في PubMed: | PMC11234511 |
DOI: | 10.1002/ajh.26827 |
PMID: | 36629030 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1096-8652 |
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DOI: | 10.1002/ajh.26827 |