دورية أكاديمية
أعرض في EDS

Immunophenotypic characterization of acute leukemias in Bahia, Brazil.

التفاصيل البيبلوغرافية
العنوان: Immunophenotypic characterization of acute leukemias in Bahia, Brazil.
المؤلفون: Santos MMD; Universidade Federal da Bahia, Salvador, BA, Brazil., Santos ASD; Universidade Federal da Bahia, Salvador, BA, Brazil., Santos HHM; Universidade Federal da Bahia, Salvador, BA, Brazil., Santos LDS; Universidade Federal da Bahia, Salvador, BA, Brazil., Nascimento RJM; Universidade Federal da Bahia, Salvador, BA, Brazil., Torres AJL; Universidade Federal da Bahia, Salvador, BA, Brazil.
المصدر: Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2023 Jan 06; Vol. 21, pp. eAO0117. Date of Electronic Publication: 2023 Jan 06 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Instituto de Ensino e Pesquisa Albert Einstein Country of Publication: Brazil NLM ID: 101281800 Publication Model: eCollection Cited Medium: Internet ISSN: 2317-6385 (Electronic) Linking ISSN: 16794508 NLM ISO Abbreviation: Einstein (Sao Paulo) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: São Paulo, SP : Instituto de Ensino e Pesquisa Albert Einstein
مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/diagnosis , Leukemia, Myeloid, Acute*/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/diagnosis, Child ; Adult ; Humans ; Brazil/epidemiology ; Retrospective Studies ; Immunophenotyping ; Acute Disease ; Flow Cytometry
مستخلص: Objective: To characterize the immunophenotypic profile of acute leukemias in the population of the state of Bahia, Brazil.
Methods: This is a descriptive, retrospective study. From 2014 to 2018, 796 new cases of acute leukemia were evaluated. The data were obtained from analysis of reports and records of tests performed by flow cytometry immunophenotyping. All individuals of all age groups diagnosed as acute lymphoblastic leukemia or acute myeloid leukemia were included in the study. Demographic variables and expression of leukemia antigens were evaluated.
Results: Most cases were diagnosed as acute myeloid leukemia and 42.7% as acute lymphoblastic leukemia. Significant differences were found in expression of markers in acute leukemias when age groups were compared, as well as in demographic characteristics. B-cell acute lymphoblastic leukemia was more prevalent than cases of T-cell origin. Assessing the aberrant markers in acute myeloid leukemias, the non-acute promyelocytic leukemia group presented expression of CD7 and CD56 as the most frequent ones. In B-cell acute lymphoblastic leukemia, the most frequent aberrant markers were CD66c, CD13 and CD33.
Conclusion: Significant differences were found as to several antigens when comparing adults and children, and these findings may contribute to future studies correlating the phenotypic profile to genetic characteristics and therapeutic response, including specific antigen therapies, which may be better targeted.
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تواريخ الأحداث: Date Created: 20230111 Date Completed: 20230113 Latest Revision: 20230113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9785573
DOI: 10.31744/einstein_journal/2023AO0117
PMID: 36629681
قاعدة البيانات: MEDLINE
الوصف
تدمد:2317-6385
DOI:10.31744/einstein_journal/2023AO0117