Rational Design of Polymethine Dyes with NIR-II Emission and High Photothermal Conversion Efficiency for Multimodal-Imaging-Guided Photo-Immunotherapy.

التفاصيل البيبلوغرافية
العنوان:	Rational Design of Polymethine Dyes with NIR-II Emission and High Photothermal Conversion Efficiency for Multimodal-Imaging-Guided Photo-Immunotherapy.
المؤلفون:	Ran XY; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Chen P; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Liu YZ; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Shi L; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Chen X; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Liu YH; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Zhang H; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Zhang LN; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Li K; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China., Yu XQ; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China.; Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Department of Chemistry, Xihua University, Chengdu, 610039, P. R. China.
المصدر:	Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2023 Mar; Vol. 35 (12), pp. e2210179. Date of Electronic Publication: 2023 Feb 10.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE
أسماء مطبوعة:	Publication: Sept. 3, 1997- : Weinheim : Wiley-VCH Original Publication: Deerfield Beach, FL : VCH Publishers, 1989-
مواضيع طبية MeSH:	Neoplasms/diagnostic imaging , Neoplasms/therapy , Breast Neoplasms* , Nanoparticles/therapeutic use , Photoacoustic Techniques/methods, Humans ; Female ; Phototherapy/methods ; Theranostic Nanomedicine/methods ; Coloring Agents ; Immunotherapy
مستخلص:	Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging ability and photothermal conversion efficiency (PCE) of phototheranostic agents. Hence, how to balance the competitive radiative and nonradiative processes of phototheranostic agents is the key factor to evaluate the phototheranostic effect. Herein, molecules named ICRs with high photostaibility are rationally designed, exhibiting fluorescence emission in the second near-infrared window (NIR-II, 1000-1700 nm) and high PCE, which are related to the strong donor-acceptor (D-A) interaction and high reorganization energy Noteworthily, ICR-Qu with stronger D-A interaction and a large-sized conjugated unit encapsulated in nanoparticles exhibits high PCE (81.1%). In addition, ICR-QuNPs are used for fluorescence imaging (FLI), photoacoustic imaging (PAI), and photothermal imaging (PTI) to guide deep-tissue photonic hyperthermia, achieving precise removal and inhibition of breast cancer. Furthermore, combined with α-PD-1, ICR-QuNPs show huge potential to be a facile and efficient tool for photo-immunotherapy. More importantly, this study not only reports an "all-in-one" polymethine-based phototheranostic agent, but also sheds light on the exploration of versatile organic molecules for future practical applications. (© 2023 Wiley-VCH GmbH.)
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معلومات مُعتمدة:	U21A20308 National Natural Science Foundation of China; 22077088 National Natural Science Foundation of China; 21877082 National Natural Science Foundation of China; 2020JDJQ0017 Foundation from Science and Technology Department of Sichuan Province; 2021YFH0132 Foundation from Science and Technology Department of Sichuan Province
فهرسة مساهمة:	Keywords: immunotherapy; photoacoustic imaging; photodynamic therapy; photothermal therapy; polymethine dyes; second near-infrared emission
المشرفين على المادة:	6441-84-5 (VPM chloride) 0 (Coloring Agents)
تواريخ الأحداث:	Date Created: 20230111 Date Completed: 20230324 Latest Revision: 20230324
رمز التحديث:	20231215
DOI:	10.1002/adma.202210179
PMID:	36630669
قاعدة البيانات:	MEDLINE

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تدمد:	1521-4095
DOI:	10.1002/adma.202210179