دورية أكاديمية
Effects of alginates on the growth, haematological, immunity, antioxidant and pro-inflammatory responses of rabbits under high temperature.
| العنوان: | Effects of alginates on the growth, haematological, immunity, antioxidant and pro-inflammatory responses of rabbits under high temperature. |
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| المؤلفون: | Saghir SAM; Department of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma'an, Jordan., Al Hroob AM; Department of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma'an, Jordan., Majrashi KA; Biological Sciences Department, College of Science & Arts, King Abdulaziz University, Rabigh 21911, Saudi Arabia., Jaber FA; Department of Biology, Faculty of Sciences, University of Jeddah, Jeddah 21959, Saudi Arabia., Abduh MS; Immune Responses in Different Diseases Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Al-Gabri N; Department of Pathology, Faculty of Veterinary Medicine, Thamar University, Dhamar, Yemen; Laboratory of Salam Veterinary Group, Buraydah, Al-Qassim, Saudi Arabia., Albaqami NM; Department of Biological Sciences, Zoology, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Abdelnour SA; Animal Production Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt., Alqhtani AH; Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia., Abd El-Hack ME; Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt., Swelum AA; Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia. Electronic address: aswelum@ksu.edu.sa., Simal-Gandara J; Universidade de Vigo, Nutrition and Bromatology Group, Analytical Chemistry and Food Science Department, Faculty of Science, E32004, Ourense, Spain. Electronic address: jsimal@uvigo.es. |
| المصدر: | Research in veterinary science [Res Vet Sci] 2023 Feb; Vol. 155, pp. 36-43. Date of Electronic Publication: 2023 Jan 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : British Veterinary Association Original Publication: Oxford. |
| مواضيع طبية MeSH: | Antioxidants*/pharmacology , Alginates*, Rabbits ; Animals ; Temperature ; Dietary Supplements/analysis ; Diet/veterinary ; Glutathione/metabolism ; Body Weight ; Animal Feed/analysis |
| مستخلص: | Heat stress (HS) is one of the most severe hurdles impacting rabbit growth, immunity, homeostasis, and productivity. Alginate oligosaccharides (AOS) have considerable beneficial effects due to their plausible antioxidant and immune-stimulatory properties. This work was planned to explore the preventive function of AOS as a new bio-feed additive against the harmful effects caused by environmental HS on growing rabbits. Rabbits were allotted in four experimental groups (25 animals in each group) and fed on a basal diet supplemented with 0.0 (AOS0), 50 (AOS50), 100 (AOS100), and 150 (AOS150) mg AOS/kg diet reared under summer conditions. Dietary AOS supplementation improved significantly (P ≤ 0.001) feed conversion rate, while both AOS100 and AOS150 significantly (P ≤ 0.001) enhanced the final body weight and body weight gain. All AOS addition significantly increased nitric oxide and lysosome activity and significantly reduced interferon-gamma (IFNγ) compared with those in the control group. Tumor necrosis factor α (TNFα), interleukin1β (IL-1β), myeloperoxidase and protein carbonyl levels were significantly reduced in rabbits fed diets containing AOS (100 and 150 mg/kg) compared with those in the control group under heat stress conditions. In addition, glutathione (GSH) and catalase (CAT) were significantly (P ≤ 0.001) improved with increasing AOS dietary levels compared with the control group. Still, total antioxidant capacity (TAC), malondialdehyde (MDA), hematocrit, mean corpuscular volume (MCV), eosinophils, and lymphocytes did not change. Erythrocyte's indices improved significantly (P ≤ 0.001), while neutrophils and white blood cell counts were decreased by dietary AOS inclusion. Immunological (IgM and IgG) were markedly reduced in AOS-treated groups compared with the control group. The current investigation exemplified that AOS as a novel bio-feed additive that could be an effective strategy to extenuate prejudicial effects in heat-stressed rabbits via enhancing immunity, and antioxidant defence system, further regulating the inflammation cytokines. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antioxidant; Heat stress; Immunity; Inflammatory cytokines; Rabbit |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Alginates) GAN16C9B8O (Glutathione) |
| تواريخ الأحداث: | Date Created: 20230112 Date Completed: 20230213 Latest Revision: 20230213 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.rvsc.2023.01.002 |
| PMID: | 36634540 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2661 |
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| DOI: | 10.1016/j.rvsc.2023.01.002 |