دورية أكاديمية
Protozoal meningoencephalitis and myelitis in 4 dogs associated with Trypanosoma cruzi infection.
| العنوان: | Protozoal meningoencephalitis and myelitis in 4 dogs associated with Trypanosoma cruzi infection. |
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| المؤلفون: | Landsgaard KA; Texas A&M University, College Station, TX., Milliron SM; Texas A&M University, College Station, TX., Faccin M; Texas A&M University, College Station, TX., Broughton CA; Texas A&M University, College Station, TX., Auckland LD; Texas A&M University, College Station, TX., Edwards JF; Texas A&M University, College Station, TX., Hamer SA; Texas A&M University, College Station, TX., Hensel ME; Texas A&M University, College Station, TX.; The University of Texas MD Anderson Cancer Center, Bastrop, TX. |
| المصدر: | Veterinary pathology [Vet Pathol] 2023 Mar; Vol. 60 (2), pp. 199-202. Date of Electronic Publication: 2023 Jan 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 0312020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1544-2217 (Electronic) Linking ISSN: 03009858 NLM ISO Abbreviation: Vet Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2010- : Thousand Oaks, CA : Sage Original Publication: 1971- : Basel : New York : Karger. |
| مواضيع طبية MeSH: | Central Nervous System Protozoal Infections*/veterinary , Chagas Disease*/parasitology , Chagas Disease*/veterinary , Myelitis*/veterinary, Dogs ; United States ; Animals ; Hospitals, Animal ; Hospitals, Teaching |
| مستخلص: | American trypanosomiasis is caused by the zoonotic protozoa Trypanosoma cruzi and primarily results in heart disease. Organisms also infect the central nervous system (CNS). The Texas A&M University veterinary teaching hospital archive was searched for dogs with CNS disease with intralesional protozoal amastigotes. This study summarizes 4 cases of dogs with disseminated trypanosomiasis and CNS involvement confirmed by quantitative polymerase chain reaction (qPCR) with T. cruzi primers. Clinical signs included lethargy, respiratory distress, tetraparesis, and seizures. Central nervous system lesions included meningeal congestion (1/4), necrosis with hemorrhage in the spinal cord gray and white matter (2/4), and histiocytic meningoencephalitis (4/4), and meningomyelitis (2/4) with intralesional and intracellular protozoal. Genotyping identified 1 case of T. cruzi discrete typing unit (DTU) TcI and 2 cases as TcIV, both are common variants in the United States. Trypanosomiasis should be considered a differential diagnosis for dogs with CNS signs in T. cruzi -endemic areas. |
| فهرسة مساهمة: | Keywords: CNS; Chagas disease; Trypanosoma cruzi; amastigotes; central nervous system; dog; trypanosomiasis |
| تواريخ الأحداث: | Date Created: 20230113 Date Completed: 20230228 Latest Revision: 20230307 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/03009858221148510 |
| PMID: | 36636956 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1544-2217 |
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| DOI: | 10.1177/03009858221148510 |