دورية أكاديمية
أعرض في EDS

Intergenerational Perioperative Neurocognitive Disorder in Young Adult Male Rats with Traumatic Brain Injury.

التفاصيل البيبلوغرافية
العنوان: Intergenerational Perioperative Neurocognitive Disorder in Young Adult Male Rats with Traumatic Brain Injury.
المؤلفون: Ju LS; Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, Florida., Zhu J; Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, Florida., Brant JO; Department of Biostatistics, University of Florida, College of Medicine, Gainesville, Florida., Morey TE; Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, Florida., Gravenstein N; Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, Florida., Seubert CN; Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, Florida., Vasilopoulos T; Departments of Anesthesiology, Orthopedic Surgery and Sports Medicine, University of Florida, College of Medicine, Gainesville, Florida., Setlow B; Department of Psychiatry and the McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, Florida., Martynyuk AE; Department of Anesthesiology and the McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, Florida.
المصدر: Anesthesiology [Anesthesiology] 2023 Apr 01; Vol. 138 (4), pp. 388-402.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1300217 Publication Model: Print Cited Medium: Internet ISSN: 1528-1175 (Electronic) Linking ISSN: 00033022 NLM ISO Abbreviation: Anesthesiology Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia Pa : Lippincott Williams & Wilkins
Original Publication: Philadelphia : American Society of Anesthesiologists
مواضيع طبية MeSH: Corticosterone*/metabolism , Brain Injuries, Traumatic*, Female ; Rats ; Animals ; Male ; Rats, Sprague-Dawley ; Sevoflurane/adverse effects ; Interleukin-1beta/metabolism ; Hippocampus/metabolism ; Neurocognitive Disorders/chemically induced
مستخلص: Background: The authors tested the hypothesis that the effects of traumatic brain injury, surgery, and sevoflurane interact to induce neurobehavioral abnormalities in adult male rats and in their offspring (an animal model of intergenerational perioperative neurocognitive disorder).
Methods: Sprague-Dawley male rats (assigned generation F0) underwent a traumatic brain injury on postnatal day 60 that involved craniectomy (surgery) under 3% sevoflurane for 40 min followed by 2.1% sevoflurane for 3 h on postnatal days 62, 64, and 66 (injury group). The surgery group had craniectomy without traumatic brain injury, whereas the sevoflurane group had sevoflurane only. On postnatal day 90, F0 males and control females were mated to generate offspring (assigned generation F1).
Results: Acutely, F0 injury rats exhibited the greatest increases in serum corticosterone and interleukin-1β and -6, and activation of the hippocampal microglia. Long-term, compared to controls, F0 injury rats had the most exacerbated corticosterone levels at rest (mean ± SD, 2.21 ± 0.64 vs. 7.28 ± 1.95 ng/ml, n = 7 - 8; P < 0.001) and 10 min after restraint (133.12 ± 33.98 vs. 232.83 ± 40.71 ng/ml, n = 7 - 8; P < 0.001), increased interleukin-1β and -6, and reduced expression of hippocampal glucocorticoid receptor (Nr3c1; 0.53 ± 0.08 fold change relative to control, P < 0.001, n = 6) and brain-derived neurotrophic factor genes. They also exhibited greater behavioral deficiencies. Similar abnormalities were evident in their male offspring, whereas F1 females were not affected. The reduced Nr3c1 expression in F1 male, but not female, hippocampus was accompanied by corresponding Nr3c1 promoter hypermethylated CpG sites in F0 spermatozoa and F1 male, but not female, hippocampus.
Conclusions: These findings in rats suggest that young adult males with traumatic brain injury are at an increased risk of developing perioperative neurocognitive disorder, as are their unexposed male but not female offspring.
(Copyright © 2023, the American Society of Anesthesiologists. All Rights Reserved.)
References: Nat Commun. 2020 Mar 20;11(1):1499. (PMID: 32198406)
Anesthesiology. 2008 Jan;108(1):18-30. (PMID: 18156878)
JAMA Neurol. 2015 Mar;72(3):355-62. (PMID: 25599342)
Stress. 2020 Nov;23(6):617-632. (PMID: 33345670)
Anesthesiology. 2014 Nov;121(5):1010-7. (PMID: 24992523)
Neurobiol Dis. 2016 Jul;91:209-220. (PMID: 27001149)
PLoS Biol. 2010 Jun 29;8(6):e1000412. (PMID: 20613859)
Clin Geriatr Med. 2018 Nov;34(4):617-635. (PMID: 30336991)
Biol Reprod. 2014 Feb 27;90(2):43. (PMID: 24451982)
Asian J Neurosurg. 2019 Nov 25;14(4):1095-1105. (PMID: 31903346)
Lancet Neurol. 2017 Dec;16(12):987-1048. (PMID: 29122524)
Am J Psychiatry. 2014 Aug;171(8):872-880. (PMID: 24832930)
Neurotrauma Rep. 2020 Oct 21;1(1):113-124. (PMID: 34223536)
Pain Physician. 2019 Sep;22(5):495-507. (PMID: 31561651)
Neurobiol Dis. 2019 Mar;123:27-41. (PMID: 30059725)
Crit Care. 2016 May 05;20(1):128. (PMID: 27145814)
Psychoneuroendocrinology. 2019 Apr;102:139-148. (PMID: 30557761)
Anesthesiology. 2019 Nov;131(5):1092-1109. (PMID: 31517640)
J Alzheimers Dis. 2018;66(1):1-10. (PMID: 30347621)
Transl Psychiatry. 2016 Jun 14;6(6):e837. (PMID: 27300263)
Psychoneuroendocrinology. 2015 Oct;60:173-81. (PMID: 26150359)
Front Neurol. 2020 Nov 24;11:564751. (PMID: 33324317)
JCI Insight. 2021 Mar 22;6(6):. (PMID: 33571165)
Mol Neurobiol. 2020 Jan;57(1):11-22. (PMID: 31512116)
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16574-9. (PMID: 24062448)
J Alzheimers Dis. 2017;57(3):667-681. (PMID: 28269777)
JAMA Facial Plast Surg. 2018 May 01;20(3):188-195. (PMID: 28983575)
Cell Metab. 2016 Apr 12;23(4):735-43. (PMID: 26908462)
Curr Neuropharmacol. 2018;16(8):1224-1238. (PMID: 28606040)
Mayo Clin Proc. 2017 Jul;92(7):1042-1052. (PMID: 28601422)
J Anesth. 2021 Oct;35(5):625-632. (PMID: 34169362)
BMC Genet. 2014 Feb 20;15:12. (PMID: 24552514)
J Neurotrauma. 2019 Nov 15;36(22):3092-3102. (PMID: 31122143)
Front Endocrinol (Lausanne). 2020 Sep 30;11:545973. (PMID: 33101193)
Curr Opin Behav Sci. 2019 Aug;28:31-37. (PMID: 31592179)
Neurosci Lett. 2017 Nov 20;661:137-142. (PMID: 28982596)
Br J Anaesth. 2018 Aug;121(2):406-416. (PMID: 30032879)
CNS Drugs. 2017 Oct;31(10):845-856. (PMID: 29039138)
Int J Environ Res Public Health. 2022 Mar 23;19(7):. (PMID: 35409484)
Biol Reprod. 2021 Sep 14;105(3):705-719. (PMID: 33982067)
Anesthesiology. 2020 Jan;132(1):55-68. (PMID: 31834869)
Brain Behav Immun. 2022 May 31;104:97-109. (PMID: 35661679)
معلومات مُعتمدة: R01 HD107722 United States HD NICHD NIH HHS; R56 HD102898 United States HD NICHD NIH HHS
المشرفين على المادة: 38LVP0K73A (Sevoflurane)
W980KJ009P (Corticosterone)
0 (Interleukin-1beta)
تواريخ الأحداث: Date Created: 20230113 Date Completed: 20230309 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC10411496
DOI: 10.1097/ALN.0000000000004496
PMID: 36637480
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-1175
DOI:10.1097/ALN.0000000000004496