دورية أكاديمية
Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele.
| العنوان: | Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele. |
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| المؤلفون: | Grzelak CA; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Center, Seattle, WA; and., Ghajar CM; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Center, Seattle, WA; and.; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA. |
| المصدر: | ImmunoHorizons [Immunohorizons] 2023 Jan 01; Vol. 7 (1), pp. 64-70. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists, Inc Country of Publication: United States NLM ID: 101708159 Publication Model: Print Cited Medium: Internet ISSN: 2573-7732 (Electronic) Linking ISSN: 25737732 NLM ISO Abbreviation: Immunohorizons Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rockville, Maryland : American Association of Immunologists, Inc., [2017]- |
| مواضيع طبية MeSH: | Alleles*, Mice ; Animals ; Humans ; Reproducibility of Results ; Mice, Inbred C57BL ; Mice, Inbred BALB C ; Mice, Transgenic |
| مستخلص: | The human ubiquitin C promoter (UBC)-driven GFP-transgenic mouse (UBC-GFP) transgene integration site was mapped recently to chromosome 17, linked closely to the MHC locus. In this study, we demonstrate a functional consequence of this insertion site in the backcrossed UBC-GFP BALB/c congenic strain [CByJ.B6-Tg(UBC-GFP) 30Scha/J]: rejection of transplanted "syngeneic" 4T1 mammary tumor cells. Rejection of BALB/c-derived 4T1 cells is in all likelihood a consequence of MHC mismatch due to stable inheritance of C57BL/6-derived H-2b (rather than prototypical H-2d) by the BALB/c UBC-GFP strain. These data are a valuable resource to researchers who have previously employed the UBC-GFP congenic strain for attempted syngeneic MHC-matched and allogenic MHC-mismatched studies, as their data likely require reinterpretation. Further, this study reemphasizes the impact of mapping transgene integration sites of commonly used mouse strains as a way of increasing scientific rigor and reproducibility. (Copyright © 2023 The Authors.) |
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| معلومات مُعتمدة: | P30 CA015704 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20230113 Date Completed: 20230117 Latest Revision: 20231025 |
| رمز التحديث: | 20231025 |
| مُعرف محوري في PubMed: | PMC10563439 |
| DOI: | 10.4049/immunohorizons.2200101 |
| PMID: | 36637515 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2573-7732 |
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| DOI: | 10.4049/immunohorizons.2200101 |