دورية أكاديمية
أعرض في EDS

Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis.

التفاصيل البيبلوغرافية
العنوان: Assessment of atherosclerosis and endothelial dysfunction risk factors in patients with primary glomerulonephritis.
المؤلفون: Hagemann R; Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, Departamento de Clínica Médica, Botucatu, São Paulo, Brazil.; Universidade Federal do Paraná, Complexo Hospital de Clínicas, Departamento de Clínica Médica, Curitiba, Paraná, Brazil., Watanabe MT; Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, Departamento de Clínica Médica, Botucatu, São Paulo, Brazil., Hueb JC; Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, Departamento de Clínica Médica, Botucatu, São Paulo, Brazil., Martín LC; Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, Departamento de Clínica Médica, Botucatu, São Paulo, Brazil., Silva VDS; Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, Departamento de Clínica Médica, Botucatu, São Paulo, Brazil., Caramori JDSCT; Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, Departamento de Clínica Médica, Botucatu, São Paulo, Brazil.
المصدر: Jornal brasileiro de nefrologia [J Bras Nefrol] 2024 Jan-Mar; Vol. 46 (1), pp. 29-38.
نوع المنشور: Controlled Clinical Trial; Journal Article; Observational Study
اللغة: English; Portuguese
بيانات الدورية: Publisher: Sociedade Brasileira de Nefrologia Country of Publication: Brazil NLM ID: 9426946 Publication Model: Print Cited Medium: Internet ISSN: 2175-8239 (Electronic) Linking ISSN: 01012800 NLM ISO Abbreviation: J Bras Nefrol Subsets: MEDLINE
أسماء مطبوعة: Publication: São Paulo : Sociedade Brasileira de Nefrologia
Original Publication: São Paulo, Brazil : Associação Medica Brasileira
مواضيع طبية MeSH: Atherosclerosis*/complications , Glomerulonephritis*/complications , Renal Insufficiency, Chronic*, Adult ; Female ; Humans ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Renal Dialysis ; Risk Factors ; Uric Acid
مستخلص: Introduction: Glomerulonephritis are the third cause of chronic kidney disease (CKD) requiring dialysis in Brazil. Mineral and bone disorder (MBD) is one of the complications of CKD and is already present in the early stages. Assessment of carotid intima-media thickness (CIMT) and flow-mediated vasodilatation (FMV) are non-invasive ways of assessing cardiovascular risk.
Hypothesis: Patients with primary glomerulonephritis (PG) have high prevalence of atherosclerosis and endothelial dysfunction, not fully explained by traditional risk factors, but probably influenced by the early onset of MBD.
Objective: To evaluate the main markers of atherosclerosis in patients with PG.
Method: Clinical, observational, cross-sectional and controlled study. Patients with PG were included and those under 18 years of age, pregnants, those with less than three months of follow-up and those with secondary glomerulonephritis were excluded. Those who, at the time of exams collection, had proteinuria higher than 6 grams/24 hours and using prednisone at doses higher than 0.2 mg/kg/day were also excluded.
Results: 95 patients were included, 88 collected the exams, 1 was excluded and 23 did not undergo the ultrasound scan. Patients with PG had a higher mean CIMT compared to controls (0.66 versus 0.60), p = 0.003. After multivariate analysis, age and values for systolic blood pressure (SBP), FMV and GFR (p = 0.02); and FMV and serum uric acid (p = 0.048) remained statistically relevant.
Discussion and Conclusion: The higher cardiovascular risk in patients with PG was not explained by early MBD. Randomized and multicentric clinical studies are necessary to better assess this hypothesis.
References: Autoimmun Rev. 2013 Aug;12(10):1004-15. (PMID: 23541482)
J Am Soc Echocardiogr. 2008 Feb;21(2):93-111; quiz 189-90. (PMID: 18261694)
Eur Heart J. 2012 Jan;33(2):183-90. (PMID: 21666250)
Nephron Clin Pract. 2008;109(1):c40-7. (PMID: 18509248)
Circulation. 2009 Jun 2;119(21):2765-71. (PMID: 19451355)
Am J Kidney Dis. 2008 Apr;51(4):584-93. (PMID: 18371534)
Biochem Biophys Res Commun. 2000 Oct 22;277(2):494-8. (PMID: 11032749)
Am Heart J. 2000 Feb;139(2 Pt 1):272-81. (PMID: 10650300)
Heart. 2013 Jun;99(11):759-66. (PMID: 23343689)
Kidney Int Suppl. 2009 Aug;(113):S1-130. (PMID: 19644521)
J Am Soc Nephrol. 2015 Feb;26(2):439-47. (PMID: 25145930)
Kidney Blood Press Res. 2018;43(6):1742-1748. (PMID: 30504710)
Am J Kidney Dis. 2013 Nov;62(5):984-92. (PMID: 23664548)
J Am Soc Nephrol. 2004 Aug;15(8):2208-18. (PMID: 15284307)
Clin J Am Soc Nephrol. 2011 Jun;6(6):1418-26. (PMID: 21527648)
Clin J Am Soc Nephrol. 2011 Aug;6(8):1887-94. (PMID: 21784838)
J Am Coll Cardiol. 2002 Jan 16;39(2):257-65. (PMID: 11788217)
Nephrol Dial Transplant. 2002 Dec;17(12):2220-5. (PMID: 12454236)
J Am Soc Nephrol. 2015 May;26(5):1150-60. (PMID: 25475745)
Eur Heart J. 2011 Nov;32(22):2851-906. (PMID: 21873417)
N Engl J Med. 2003 Dec 18;349(25):2399-406. (PMID: 14681505)
Kidney Int. 2007 Mar;71(6):562-8. (PMID: 17228363)
Lancet. 1992 Nov 7;340(8828):1111-5. (PMID: 1359209)
Blood Purif. 2006;24(1):56-62. (PMID: 16361842)
Arq Bras Cardiol. 2018 May;110(5):402-410. (PMID: 29641646)
Kidney Blood Press Res. 2012;35(3):153-60. (PMID: 22116196)
Cerebrovasc Dis. 2007;23(1):75-80. (PMID: 17108679)
Clin J Am Soc Nephrol. 2009 Jun;4(6):1136-9. (PMID: 19423568)
J Am Soc Nephrol. 2004 Jan;15 Suppl 1:S77-80. (PMID: 14684678)
Ann Intern Med. 2009 May 5;150(9):604-12. (PMID: 19414839)
J Clin Invest. 2011 Nov;121(11):4393-408. (PMID: 21985788)
Nephrol Dial Transplant. 2019 Dec 1;34(12):1986-1990. (PMID: 30903187)
Circulation. 2002 Mar 5;105(9):1135-43. (PMID: 11877368)
N Engl J Med. 2004 Sep 23;351(13):1285-95. (PMID: 15385655)
Kidney Int. 1993 Sep;44(3):638-42. (PMID: 8231039)
BMC Nephrol. 2017 Mar 20;18(1):95. (PMID: 28320366)
المشرفين على المادة: 268B43MJ25 (Uric Acid)
تواريخ الأحداث: Date Created: 20230113 Date Completed: 20240304 Latest Revision: 20240327
رمز التحديث: 20240327
مُعرف محوري في PubMed: PMC10962406
DOI: 10.1590/2175-8239-JBN-2022-0116en
PMID: 36638246
قاعدة البيانات: MEDLINE
الوصف
تدمد:2175-8239
DOI:10.1590/2175-8239-JBN-2022-0116en