دورية أكاديمية
A new alkaloid derivative from the saprophytic fungus Neohelicomyces hyalosporus PF11-1.
| العنوان: | A new alkaloid derivative from the saprophytic fungus Neohelicomyces hyalosporus PF11-1. |
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| المؤلفون: | Zheng W; College of Life Sciences, Guizhou University, Guiyang, P.R. China.; Engineering Research Center of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guiyang, P.R. China., Han L; College of Life Sciences, Guizhou University, Guiyang, P.R. China.; Engineering Research Center of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guiyang, P.R. China., He ZJ; Engineering Research Center of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guiyang, P.R. China., Kang JC; College of Life Sciences, Guizhou University, Guiyang, P.R. China.; Engineering Research Center of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guiyang, P.R. China. |
| المصدر: | Natural product research [Nat Prod Res] 2024 Jul; Vol. 38 (13), pp. 2215-2219. Date of Electronic Publication: 2023 Jan 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Alkaloids*/pharmacology , Alkaloids*/chemistry, Humans ; Molecular Structure ; Cell Line, Tumor ; Ascomycota/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Drug Screening Assays, Antitumor ; Fermentation ; Magnetic Resonance Spectroscopy ; Inhibitory Concentration 50 |
| مستخلص: | A new alkaloid, neohelicomyine A ( 1 ), along with two known alkaloids ( 2 - 3 ), were isolated from the fermentation of Neohelicomyces hyalosporus PF11-1. The structures of these compounds were elucidated by extensive analyses of spectroscopic methods including 1 D and 2 D NMR, HRESIMS and ECD. The bioactivities of all compounds were evaluated using cellular assays, and compounds 2 and 3 displayed moderate cytotoxicities against human cancer (A549, TCA, RD) cells with IC |
| فهرسة مساهمة: | Keywords: Neohelicomyces hyalosporus; Saprophytic fungi; alkaloid; cytotoxicity |
| المشرفين على المادة: | 0 (Alkaloids) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20230116 Date Completed: 20240711 Latest Revision: 20240711 |
| رمز التحديث: | 20240711 |
| DOI: | 10.1080/14786419.2023.2167202 |
| PMID: | 36644981 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2023.2167202 |