دورية أكاديمية
Effect of TNF inhibitors on arterial stiffness and intima media thickness in rheumatoid arthritis: a systematic review and meta-analysis.
العنوان: | Effect of TNF inhibitors on arterial stiffness and intima media thickness in rheumatoid arthritis: a systematic review and meta-analysis. |
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المؤلفون: | Abdulmajid B; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Location Reade, Amsterdam Dr. Jan van Breemenstraat 2, PO Box 58271, 1040 HG, Amsterdam, The Netherlands. bafrinam@hotmail.com.; Amsterdam UMC, Location AMC, Amsterdam, The Netherlands. bafrinam@hotmail.com., Blanken AB; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Location Reade, Amsterdam Dr. Jan van Breemenstraat 2, PO Box 58271, 1040 HG, Amsterdam, The Netherlands.; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Location Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.; Department of Medical Library, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., van Geel EH; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Location Reade, Amsterdam Dr. Jan van Breemenstraat 2, PO Box 58271, 1040 HG, Amsterdam, The Netherlands.; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Location Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands., Daams JG; Department of Medical Library, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Nurmohamed MT; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Location Reade, Amsterdam Dr. Jan van Breemenstraat 2, PO Box 58271, 1040 HG, Amsterdam, The Netherlands.; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Location Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.; Department of Medical Library, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands. |
المصدر: | Clinical rheumatology [Clin Rheumatol] 2023 Apr; Vol. 42 (4), pp. 999-1011. Date of Electronic Publication: 2023 Jan 16. |
نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2008->: Heidelberg : Springer Original Publication: Brussels : Acta Medica Belgica, [1982- |
مواضيع طبية MeSH: | Arthritis, Rheumatoid*/complications , Arthritis, Rheumatoid*/drug therapy , Arthritis, Rheumatoid*/pathology , Tumor Necrosis Factor Inhibitors*/therapeutic use , Vascular Stiffness*/drug effects, Humans ; Carotid Intima-Media Thickness ; Prospective Studies ; Pulse Wave Analysis/methods ; Risk Factors |
مستخلص: | Controlling inflammation with tumor necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients is hypothesized to reduce their cardiovascular risk. We performed a systematic review and meta-analysis on the effects of TNF inhibitors on arterial stiffness and carotid intima media thickness (IMT) in RA. MEDLINE, EMBASE, clinicaltrials.gov , and WHO Clinical Trials Registry were searched up to September 2021 for randomized controlled trials, prospective cohort studies, and nonrandomized clinical trials evaluating the effects of TNF inhibitors on pulse wave velocity (PWV), augmentation index (AIx), and IMT in RA. A meta-analysis was performed to assess changes of these measures after therapy during different follow-up periods. Risk of bias assessment was performed using an adjusted Downs and Black checklist (INPLASY: 2022-1-0131). Thirty studies were identified from 1436 records, of which 23 were included in the meta-analysis. PWV and AIx showed a decrease after treatment (PWV: mean difference (MD) -0.51 m/s (95% CI: -0.96, -0.06), p=0.027; AIx: MD -0.57% (95% CI: -2.11, 0.96), p=0.463, sensitivity analysis AIx: MD -1.21% (95% CI: -2.60, 0.19), p=0.089). For IMT, there was a slight increase in the first months of follow-up, but this disappeared on the long-term (overall timepoints MD -0.01 mm (95% CI: -0.04, 0.02), p=0.615). Heterogeneity was high in the overall analyses and subgroups with long follow-up periods (≥12 months). The included studies showed mixed results of the effects of TNF inhibitors on the surrogate markers. The pooled results suggest that PWV and AIx decrease over time, while IMT remains stable. This indicates a favorable effect of TNF inhibitors on the cardiovascular disease risk, all the more since these markers also increase with age. (© 2023. The Author(s).) |
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فهرسة مساهمة: | Keywords: Cardiovascular burden; Rheumatoid arthritis; Systematic review; Tumor necrosis factor inhibitors |
المشرفين على المادة: | 0 (Tumor Necrosis Factor Inhibitors) |
تواريخ الأحداث: | Date Created: 20230116 Date Completed: 20230330 Latest Revision: 20230330 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10017587 |
DOI: | 10.1007/s10067-023-06505-y |
PMID: | 36645550 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1434-9949 |
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DOI: | 10.1007/s10067-023-06505-y |